BRPI0414107B8 - produtos intermediários para a preparação de híbridos de oxazolidinon-quinolona - Google Patents

produtos intermediários para a preparação de híbridos de oxazolidinon-quinolona

Info

Publication number
BRPI0414107B8
BRPI0414107B8 BRPI0414107A BRPI0414107A BRPI0414107B8 BR PI0414107 B8 BRPI0414107 B8 BR PI0414107B8 BR PI0414107 A BRPI0414107 A BR PI0414107A BR PI0414107 A BRPI0414107 A BR PI0414107A BR PI0414107 B8 BRPI0414107 B8 BR PI0414107B8
Authority
BR
Brazil
Prior art keywords
oxazolidinon
preparation
intermediate products
quinolone
hybrids
Prior art date
Application number
BRPI0414107A
Other languages
English (en)
Inventor
Hubschwerlen Christian
K Baeschlin Daniel
Philippe Surivet Jean
Specklin Jean-Luc
Original Assignee
Morphochem Ag Fuer Komb Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem Ag Fuer Komb Chemie filed Critical Morphochem Ag Fuer Komb Chemie
Publication of BRPI0414107A publication Critical patent/BRPI0414107A/pt
Publication of BRPI0414107B1 publication Critical patent/BRPI0414107B1/pt
Publication of BRPI0414107B8 publication Critical patent/BRPI0414107B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"produtos intermediários para a preparação de híbridos de oxazolidinon-quinolona". a presente invenção descreve produtos intermediários (zp) para uma síntese nova e eficiente de compostos, nos quais os farmacóforos de quinolona e oxazolidinona estão ligados uns com os outros através de um ligante quimicamente estável.
BRPI0414107A 2003-09-03 2004-09-03 produtos intermediários para a preparação de híbridos de oxazolidinon-quinolona BRPI0414107B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10340485.6 2003-09-03
DE2003140485 DE10340485B4 (de) 2003-09-03 2003-09-03 Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
PCT/EP2004/009858 WO2005023801A1 (de) 2003-09-03 2004-09-03 Zwischenprodukte für die herstellung von oxazolidinon-chinolon hybriden

Publications (3)

Publication Number Publication Date
BRPI0414107A BRPI0414107A (pt) 2007-04-27
BRPI0414107B1 BRPI0414107B1 (pt) 2018-07-03
BRPI0414107B8 true BRPI0414107B8 (pt) 2021-05-25

Family

ID=34258351

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414107A BRPI0414107B8 (pt) 2003-09-03 2004-09-03 produtos intermediários para a preparação de híbridos de oxazolidinon-quinolona

Country Status (16)

Country Link
US (2) US7557214B2 (pt)
EP (2) EP1660489B1 (pt)
JP (1) JP4742039B2 (pt)
KR (1) KR101211025B1 (pt)
CN (1) CN100467466C (pt)
AU (1) AU2004270379B2 (pt)
BR (1) BRPI0414107B8 (pt)
CA (1) CA2537345C (pt)
DE (1) DE10340485B4 (pt)
ES (1) ES2509868T3 (pt)
IL (2) IL173407A0 (pt)
MX (1) MXPA06002366A (pt)
NZ (1) NZ545491A (pt)
RU (1) RU2373203C2 (pt)
WO (1) WO2005023801A1 (pt)
ZA (1) ZA200601178B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
ES2308171T3 (es) * 2003-04-30 2008-12-01 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
CA2549675C (en) 2003-12-18 2012-11-20 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
US20080176860A1 (en) * 2007-01-19 2008-07-24 Lutz Weber Pyridin-2-one compounds
CN105246476B (zh) 2013-05-28 2019-11-15 莫弗凯姆联合化学股份公司 含噁唑烷酮-喹诺酮的联合疗法在治疗细菌感染中的应用
MX371037B (es) 2013-05-28 2020-01-14 Morphochem Aktiengesellschaft Fuer Komb Chemie Antibacterianos híbridos de oxazolidinona-quinolona para el tratamiento parenteral o profilaxis de enfermedades bacterianas.
CN108059624A (zh) * 2016-11-08 2018-05-22 上海医药工业研究院 用于制备咔哒唑胺关键中间体的制备方法
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid

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US4840956A (en) * 1986-02-18 1989-06-20 Warner-Lambert Company Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH0269478A (ja) 1988-09-05 1990-03-08 Sagami Chem Res Center キノロンカルボン酸誘導体
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
EP0390215B1 (en) 1989-03-30 1995-06-07 Wakunaga Seiyaku Kabushiki Kaisha Quinolone derivatives and salts thereof, preparation process es thereof, and antibacterial agents containing the same
AU667198B2 (en) 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
US5221676A (en) * 1992-02-06 1993-06-22 Warner-Lambert Company 7-substituted quinolones and naphthyridones as antibacterial agents
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
RU2171252C2 (ru) * 1995-09-22 2001-07-27 Вакунага Фармасьютикал КО., Лтд. Аминосоединение для получения новых производных пиридонкарбоновой кислоты или их солей
DE19601265A1 (de) * 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
DE19633480A1 (de) * 1996-08-20 1998-02-26 Bayer Ag Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
WO1999037630A1 (en) * 1998-01-23 1999-07-29 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
KR100324621B1 (ko) 1999-04-27 2002-02-27 박호군 퀴놀론이 치환된 옥사졸리디논 유도체 및 그의 제조 방법과 항균제로서의 용도
US6441005B1 (en) * 1999-07-28 2002-08-27 Pharmacia & Upjohn Company Oxazolidinone compounds and compositions, and methods of using the same
US6518285B2 (en) * 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
ATE319710T1 (de) 2000-12-21 2006-03-15 Pharmacia & Upjohn Co Llc Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen
ES2186550B2 (es) 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
WO2003031443A1 (en) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
WO2003031441A1 (en) 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
CN1625555A (zh) 2002-02-01 2005-06-08 阿斯特拉曾尼卡有限公司 喹唑啉化合物
US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
WO2004069816A1 (en) * 2003-02-07 2004-08-19 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
ES2308171T3 (es) * 2003-04-30 2008-12-01 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
CA2549675C (en) * 2003-12-18 2012-11-20 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) * 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
ATE544764T1 (de) 2006-11-10 2012-02-15 Actelion Pharmaceuticals Ltd 5-hydroxymethyloxazolidin-2-onderivate
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
RU2527769C2 (ru) 2008-05-09 2014-09-10 Актелион Фармасьютиклз Лтд Производные 5-гидроксиметилоксазолидин-2-она для лечения бактериальных кишечных заболеваний

Also Published As

Publication number Publication date
EP2374806A1 (de) 2011-10-12
WO2005023801A1 (de) 2005-03-17
US7557214B2 (en) 2009-07-07
CN1845923A (zh) 2006-10-11
JP2007504262A (ja) 2007-03-01
DE10340485B4 (de) 2015-05-13
EP2374806B1 (de) 2016-11-02
EP1660489A1 (de) 2006-05-31
US20090306389A1 (en) 2009-12-10
AU2004270379B2 (en) 2011-03-31
EP1660489B1 (de) 2014-07-02
JP4742039B2 (ja) 2011-08-10
MXPA06002366A (es) 2006-06-20
RU2006110535A (ru) 2007-10-10
BRPI0414107A (pt) 2007-04-27
RU2373203C2 (ru) 2009-11-20
AU2004270379A1 (en) 2005-03-17
CA2537345A1 (en) 2005-03-17
ZA200601178B (en) 2007-04-25
IL205706A (en) 2013-06-27
KR101211025B1 (ko) 2012-12-11
US8124772B2 (en) 2012-02-28
ES2509868T3 (es) 2014-10-20
CA2537345C (en) 2013-01-29
KR20060121849A (ko) 2006-11-29
US20070004769A1 (en) 2007-01-04
DE10340485A1 (de) 2005-05-12
HK1083848A1 (en) 2006-07-14
NZ545491A (en) 2009-12-24
CN100467466C (zh) 2009-03-11
IL205706A0 (en) 2011-08-01
IL173407A0 (en) 2006-06-11
BRPI0414107B1 (pt) 2018-07-03

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 413/12, 263/20; A61P 31/00

Ipc: C07D 413/12 (2011.01), C07D 263/20 (2011.01), A61P

Free format text: "PARA: INT. CL. C07D 413/12, 263/20

Ipc: C07D 413/12 (2011.01), C07D 263/20 (2011.01), A61P

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/09/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2846 DE 22-07-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.