BRPI0414436A - processo para a preparação de derivados de 2-oxo-1-pirrolidina e seus sais - Google Patents

processo para a preparação de derivados de 2-oxo-1-pirrolidina e seus sais

Info

Publication number
BRPI0414436A
BRPI0414436A BRPI0414436-8A BRPI0414436A BRPI0414436A BR PI0414436 A BRPI0414436 A BR PI0414436A BR PI0414436 A BRPI0414436 A BR PI0414436A BR PI0414436 A BRPI0414436 A BR PI0414436A
Authority
BR
Brazil
Prior art keywords
oxo
salts
preparation
pyrrolidine derivatives
pyrrolidine
Prior art date
Application number
BRPI0414436-8A
Other languages
English (en)
Inventor
John Surtees
Francoise Lurquin
Ousmane Diouf
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of BRPI0414436A publication Critical patent/BRPI0414436A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE 2-OXO-1-PIRROLIDINA E SEUS SAIS". A presente invenção diz respeito a um novo processo para preparar derivados de 2-oxo-1-pirrolidina de fórmula geral (I) em que os substituintes são como definidos no relatório descritivo.
BRPI0414436-8A 2003-09-24 2004-09-13 processo para a preparação de derivados de 2-oxo-1-pirrolidina e seus sais BRPI0414436A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03021534 2003-09-24
PCT/EP2004/010212 WO2005028435A1 (en) 2003-09-24 2004-09-13 Process for preparing 2-oxo-1-pyrrolidine derivatives

Publications (1)

Publication Number Publication Date
BRPI0414436A true BRPI0414436A (pt) 2006-11-14

Family

ID=34354424

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414436-8A BRPI0414436A (pt) 2003-09-24 2004-09-13 processo para a preparação de derivados de 2-oxo-1-pirrolidina e seus sais

Country Status (14)

Country Link
US (1) US7629474B2 (pt)
EP (1) EP1667967B1 (pt)
JP (1) JP4658937B2 (pt)
KR (1) KR101124098B1 (pt)
CN (1) CN1882535B (pt)
BR (1) BRPI0414436A (pt)
CA (1) CA2538938C (pt)
DK (1) DK1667967T3 (pt)
EA (1) EA010306B1 (pt)
ES (1) ES2390455T3 (pt)
IL (1) IL174029A (pt)
PL (1) PL1667967T3 (pt)
WO (1) WO2005028435A1 (pt)
ZA (1) ZA200601970B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080194840A1 (en) * 2005-04-01 2008-08-14 Rubamin Laboratories Limited Process for Preparing Levetiracetam and Racemization of (R)- and (S)-2-Amino Butynamide and the Corresponding Acid Derivatives
KR101207529B1 (ko) * 2005-09-15 2012-12-04 유씨비 파마, 에스.에이. 4-치환된 피롤리딘-2-온 및 이들의 용도
US8076493B2 (en) 2005-12-07 2011-12-13 Ucb Pharma, S.A. 3-carboxy-2-oxo-1-pyrrolidine derivatives and their uses
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
HUE064612T2 (hu) 2015-05-25 2024-04-28 Suzhou Pengxu Pharmatech Co Ltd Eljárás brivaracetam elõállítására
EP3371150B1 (en) 2015-11-03 2021-08-18 UCB Biopharma SRL Process for preparing brivaracetam
WO2017076737A1 (en) 2015-11-03 2017-05-11 Ucb Biopharma Sprl Continuous process for preparing brivaracetam
CN105646319B (zh) * 2015-12-30 2018-05-18 佛山市隆信医药科技有限公司 一种布瓦西坦的制备方法
CN107513031B (zh) * 2016-06-16 2022-08-02 上海医药集团股份有限公司 一种2-氧代-1-吡咯烷手性衍生物的制备方法
CN108218757A (zh) * 2016-12-14 2018-06-29 上海医药集团股份有限公司 对2-(4-丙基吡咯烷-2-酮)-丁酰胺非对映异构体的拆分方法
CN106748950B (zh) * 2017-01-13 2019-09-03 成都美域高制药有限公司 一种布瓦西坦及其中间体的制备方法
CN108658831B (zh) * 2017-03-30 2021-11-05 江苏豪森药业集团有限公司 2-氧代-1-吡咯烷衍生物或其盐的制备方法
CN107793342A (zh) * 2017-10-19 2018-03-13 丽珠集团新北江制药股份有限公司 一种布瓦西坦的制备方法
CN108548873A (zh) * 2018-03-20 2018-09-18 丽珠集团新北江制药股份有限公司 一种布瓦西坦中间体异构体的检测方法
CN108929289B (zh) * 2018-06-19 2022-01-04 上海博氏医药科技有限公司 一种用于制备布瓦西坦的中间体化合物及其制备方法和用途
CN110615744B (zh) 2018-06-20 2023-01-06 上海朴颐化学科技有限公司 一种布瓦西坦中间体及其制备方法
CN111333563B (zh) * 2018-12-19 2023-11-07 上海科胜药物研发有限公司 一种布瓦西坦中间体的制备方法
CN111892526A (zh) * 2019-05-06 2020-11-06 北京万全德众医药生物技术有限公司 一种布瓦西坦的新制备方法
CA3131419C (en) 2019-06-11 2024-03-05 Jilin Asymchem Laboratories Co., Ltd. Continuous synthesis method for 1,1'-bicyclo[1.1.1]pentane-1,3-diethyl ketone compounds
WO2021217579A1 (zh) 2020-04-30 2021-11-04 上海科胜药物研发有限公司 布瓦西坦及其中间体的制备方法
WO2023100110A1 (en) 2021-12-02 2023-06-08 Macfarlan Smith Limited Process for preparing brivaracetam

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8412357D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
GB8827389D0 (en) 1988-11-23 1988-12-29 Ucb Sa Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide
GB0004297D0 (en) 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
DE60204224T2 (de) * 2001-03-22 2006-02-02 Ucb S.A. Verwendung bestimmter substituierter pyrrolidone wie z.b. piracetam bei der behandlung von viralen und anderen erkrankungen
WO2002094787A1 (en) 2001-05-23 2002-11-28 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
DE60229267D1 (de) * 2001-08-10 2008-11-20 Ucb Pharma Sa Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen

Also Published As

Publication number Publication date
IL174029A0 (en) 2006-08-01
AU2004274157A1 (en) 2005-03-31
PL1667967T3 (pl) 2012-11-30
EP1667967B1 (en) 2012-08-01
ZA200601970B (en) 2007-05-30
CN1882535A (zh) 2006-12-20
KR20060121889A (ko) 2006-11-29
DK1667967T3 (da) 2012-10-08
WO2005028435A1 (en) 2005-03-31
IL174029A (en) 2012-06-28
EA200600485A1 (ru) 2007-02-27
ES2390455T3 (es) 2012-11-13
CN1882535B (zh) 2011-05-11
HK1094702A1 (en) 2007-04-04
EA010306B1 (ru) 2008-08-29
CA2538938A1 (en) 2005-03-31
EP1667967A1 (en) 2006-06-14
CA2538938C (en) 2011-08-09
JP2007515387A (ja) 2007-06-14
KR101124098B1 (ko) 2012-03-21
US20070100150A1 (en) 2007-05-03
JP4658937B2 (ja) 2011-03-23
US7629474B2 (en) 2009-12-08

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: UCB PHARMA S.A. (BE)

Free format text: TRANSFERIDO DE: UCB S.A.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 207/26, C07D 207/267, C07D 207/277, A61P 25/08

Ipc: C07D 207/26 (2011.01)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL