BRPI0414463A - ácidos heteroarilbenzofuránicos substituìdos - Google Patents

ácidos heteroarilbenzofuránicos substituìdos

Info

Publication number
BRPI0414463A
BRPI0414463A BRPI0414463-5A BRPI0414463A BRPI0414463A BR PI0414463 A BRPI0414463 A BR PI0414463A BR PI0414463 A BRPI0414463 A BR PI0414463A BR PI0414463 A BRPI0414463 A BR PI0414463A
Authority
BR
Brazil
Prior art keywords
acids
substituted
heteroarylbenzofuranic
methods
present
Prior art date
Application number
BRPI0414463-5A
Other languages
English (en)
Inventor
Hassan Mahmoud Elokdah
Geraldine Ruth Mcfarlane
Scott Christian Mayer
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0414463A publication Critical patent/BRPI0414463A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

"áCIDOS HETEROARILBENZOFURáNICOS SUBSTITUìDOS". A presente invenção refere-se geralmente a ácidos heteroarilbenzofurânicos substituídos e a métodos para utilizá-los (I); ou uma forma de um sal ou éster farmaceuticamente aceitável sua em que: R, R~ 1~, R~ 2~ e R~ 3~ são, independentemente, hidrogênio, alquil, cicloalquil, alcanoil, halogênio, hidróxi, aril, perfluoralquil, alcóxi, amino, alquilamino, dialquilamino ou perfluoralcóxi; R~ 4~ é hidrogênio, alquil, perfluoralquil, alquenil, alquinil, arilalquenil, arilalquinil, aril, -C(=O)R~ 5~, -C(=S)R~ 5~, -CH~ 2~R~ 5~, ou -CH(OH)R~ 5~. R~ 5~ é hidrogênio, alquil C~ 1~-C~ 8~, cicloalquil C~ 3~-C~ 8~, perfluoralquil, aril, alquenil, alquinil, arilalquil, arilalquenil, arilalquinil, alquilaril, alquenilaril ou alquinilaril; R~ 6~, é hidrogênio, alquil, aril ou arilalquil; x~ 1~, x~ 2~, x~ 3~, x~ 4~, x~ 5~, x~ 6~, x~ 7~ e x~ 8~ são, independentemente, carbono ou nitrogênio, em que pelo menos um de X~ 1~-X~ 8~ é um átomo de nitrogênio; em é um número inteiro de 0 a 6; e A é um ácido imitativo.ou um sal farmaceuticamente aceitável seu.
BRPI0414463-5A 2003-09-25 2004-09-24 ácidos heteroarilbenzofuránicos substituìdos BRPI0414463A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50601203P 2003-09-25 2003-09-25
US10/947,840 US7446201B2 (en) 2003-09-25 2004-09-23 Substituted heteroaryl benzofuran acids
PCT/US2004/031364 WO2005030760A1 (en) 2003-09-25 2004-09-24 Substituted heteroaryl benzofuran acids

Publications (1)

Publication Number Publication Date
BRPI0414463A true BRPI0414463A (pt) 2006-11-14

Family

ID=34396284

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414463-5A BRPI0414463A (pt) 2003-09-25 2004-09-24 ácidos heteroarilbenzofuránicos substituìdos

Country Status (13)

Country Link
US (2) US7446201B2 (pt)
EP (1) EP1668001B1 (pt)
JP (1) JP2007506760A (pt)
AT (1) ATE412649T1 (pt)
AU (1) AU2004276305A1 (pt)
BR (1) BRPI0414463A (pt)
CA (1) CA2538711A1 (pt)
DE (1) DE602004017486D1 (pt)
DK (1) DK1668001T3 (pt)
ES (1) ES2315711T3 (pt)
MX (1) MXPA06003249A (pt)
PL (1) PL1668001T3 (pt)
WO (1) WO2005030760A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7074817B2 (en) * 2001-06-20 2006-07-11 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
TWI224101B (en) * 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
EP1569900B1 (en) * 2002-12-10 2006-06-28 Wyeth Substituted 3-carbonyl-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
CA2509170A1 (en) * 2002-12-10 2004-06-24 Wyeth Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
UA80453C2 (en) * 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
DE60324183D1 (en) * 2002-12-10 2008-11-27 Wyeth Corp Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1)
US7332521B2 (en) * 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7342039B2 (en) * 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7534894B2 (en) * 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
US7446201B2 (en) * 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7265148B2 (en) * 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7411083B2 (en) * 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7582773B2 (en) * 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7141592B2 (en) * 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7163954B2 (en) * 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7442805B2 (en) * 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
AU2005277137A1 (en) * 2004-08-23 2006-03-02 Wyeth Pyrrolo-naphthyl acids as PAI-1 inhibitors
WO2006023865A1 (en) * 2004-08-23 2006-03-02 Wyeth Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases
CN101044127A (zh) 2004-08-23 2007-09-26 惠氏公司 用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸
BRPI0614340A2 (pt) * 2005-08-17 2011-04-12 Wyeth Corp indóis substituìdos e métodos de seu uso
AR059629A1 (es) * 2006-02-27 2008-04-16 Wyeth Corp Inhibidores del inhibidor del activador de plasminogeno (pai- 1) para el tratamiento de trastornos musculares
AU2007309708A1 (en) * 2006-03-13 2008-05-02 Merck Sharp & Dohme Corp. Somatostatin agonists
CN105294662B (zh) * 2015-09-11 2018-04-20 中山大学 苯并呋喃喹啉衍生物及其在制备治疗阿尔茨海默病症的药品中的应用

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US7446201B2 (en) * 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US20050215626A1 (en) 2003-09-25 2005-09-29 Wyeth Substituted benzofuran oximes

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DE602004017486D1 (de) 2008-12-11
AU2004276305A1 (en) 2005-04-07
EP1668001B1 (en) 2008-10-29
WO2005030760A1 (en) 2005-04-07
JP2007506760A (ja) 2007-03-22
US20090054484A1 (en) 2009-02-26
MXPA06003249A (es) 2006-06-08
PL1668001T3 (pl) 2009-04-30
ATE412649T1 (de) 2008-11-15
US20050119296A1 (en) 2005-06-02
EP1668001A1 (en) 2006-06-14
DK1668001T3 (da) 2009-02-16
US7446201B2 (en) 2008-11-04
ES2315711T3 (es) 2009-04-01
CA2538711A1 (en) 2005-04-07

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