BRPI0414463A - ácidos heteroarilbenzofuránicos substituìdos - Google Patents

ácidos heteroarilbenzofuránicos substituìdos

Info

Publication number
BRPI0414463A
BRPI0414463A BRPI0414463-5A BRPI0414463A BRPI0414463A BR PI0414463 A BRPI0414463 A BR PI0414463A BR PI0414463 A BRPI0414463 A BR PI0414463A BR PI0414463 A BRPI0414463 A BR PI0414463A
Authority
BR
Brazil
Prior art keywords
acids
substituted
heteroarylbenzofuranic
methods
present
Prior art date
Application number
BRPI0414463-5A
Other languages
English (en)
Inventor
Hassan Mahmoud Elokdah
Geraldine Ruth Mcfarlane
Scott Christian Mayer
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0414463A publication Critical patent/BRPI0414463A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

"áCIDOS HETEROARILBENZOFURáNICOS SUBSTITUìDOS". A presente invenção refere-se geralmente a ácidos heteroarilbenzofurânicos substituídos e a métodos para utilizá-los (I); ou uma forma de um sal ou éster farmaceuticamente aceitável sua em que: R, R~ 1~, R~ 2~ e R~ 3~ são, independentemente, hidrogênio, alquil, cicloalquil, alcanoil, halogênio, hidróxi, aril, perfluoralquil, alcóxi, amino, alquilamino, dialquilamino ou perfluoralcóxi; R~ 4~ é hidrogênio, alquil, perfluoralquil, alquenil, alquinil, arilalquenil, arilalquinil, aril, -C(=O)R~ 5~, -C(=S)R~ 5~, -CH~ 2~R~ 5~, ou -CH(OH)R~ 5~. R~ 5~ é hidrogênio, alquil C~ 1~-C~ 8~, cicloalquil C~ 3~-C~ 8~, perfluoralquil, aril, alquenil, alquinil, arilalquil, arilalquenil, arilalquinil, alquilaril, alquenilaril ou alquinilaril; R~ 6~, é hidrogênio, alquil, aril ou arilalquil; x~ 1~, x~ 2~, x~ 3~, x~ 4~, x~ 5~, x~ 6~, x~ 7~ e x~ 8~ são, independentemente, carbono ou nitrogênio, em que pelo menos um de X~ 1~-X~ 8~ é um átomo de nitrogênio; em é um número inteiro de 0 a 6; e A é um ácido imitativo.ou um sal farmaceuticamente aceitável seu.
BRPI0414463-5A 2003-09-25 2004-09-24 ácidos heteroarilbenzofuránicos substituìdos BRPI0414463A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50601203P 2003-09-25 2003-09-25
US10/947,840 US7446201B2 (en) 2003-09-25 2004-09-23 Substituted heteroaryl benzofuran acids
PCT/US2004/031364 WO2005030760A1 (en) 2003-09-25 2004-09-24 Substituted heteroaryl benzofuran acids

Publications (1)

Publication Number Publication Date
BRPI0414463A true BRPI0414463A (pt) 2006-11-14

Family

ID=34396284

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414463-5A BRPI0414463A (pt) 2003-09-25 2004-09-24 ácidos heteroarilbenzofuránicos substituìdos

Country Status (13)

Country Link
US (2) US7446201B2 (pt)
EP (1) EP1668001B1 (pt)
JP (1) JP2007506760A (pt)
AT (1) ATE412649T1 (pt)
AU (1) AU2004276305A1 (pt)
BR (1) BRPI0414463A (pt)
CA (1) CA2538711A1 (pt)
DE (1) DE602004017486D1 (pt)
DK (1) DK1668001T3 (pt)
ES (1) ES2315711T3 (pt)
MX (1) MXPA06003249A (pt)
PL (1) PL1668001T3 (pt)
WO (1) WO2005030760A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60221391T2 (de) * 2001-06-20 2008-04-17 Wyeth Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1)
TWI224101B (en) * 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
AU2003296324A1 (en) * 2002-12-10 2004-06-30 Wyeth Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
MXPA05006288A (es) * 2002-12-10 2005-08-19 Wyeth Corp Derivados del acido 3-carbonil-1h-indol-1-ilacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1).
UA80453C2 (en) * 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
BR0316583A (pt) * 2002-12-10 2005-10-04 Wyeth Corp Derivados de ácido acético 3-alquil e 3-arilalquil 1h-indol-1-il substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1)
US7411083B2 (en) * 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7582773B2 (en) * 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7163954B2 (en) * 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7141592B2 (en) * 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7446201B2 (en) * 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7342039B2 (en) * 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7265148B2 (en) * 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7534894B2 (en) * 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
US7332521B2 (en) * 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7442805B2 (en) * 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
EP1794138A2 (en) * 2004-08-23 2007-06-13 Wyeth Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1
JP2008510814A (ja) * 2004-08-23 2008-04-10 ワイス Ｐａｉ−１阻害剤としてのピロロ−ナフチル酸
MX2007002178A (es) * 2004-08-23 2007-04-02 Wyeth Corp Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares.
CN101263115A (zh) * 2005-08-17 2008-09-10 惠氏公司 经取代吲哚和其用途
PE20071017A1 (es) * 2006-02-27 2007-11-12 Wyeth Corp Derivados de acido indol sustituido como inhibidores del activador de plasminogeno tipo 1 (pai-1)
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CN105294662B (zh) * 2015-09-11 2018-04-20 中山大学 苯并呋喃喹啉衍生物及其在制备治疗阿尔茨海默病症的药品中的应用

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US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
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US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7446201B2 (en) * 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones

Also Published As

Publication number Publication date
US7446201B2 (en) 2008-11-04
JP2007506760A (ja) 2007-03-22
AU2004276305A1 (en) 2005-04-07
WO2005030760A1 (en) 2005-04-07
PL1668001T3 (pl) 2009-04-30
ES2315711T3 (es) 2009-04-01
CA2538711A1 (en) 2005-04-07
EP1668001B1 (en) 2008-10-29
DK1668001T3 (da) 2009-02-16
MXPA06003249A (es) 2006-06-08
ATE412649T1 (de) 2008-11-15
US20090054484A1 (en) 2009-02-26
DE602004017486D1 (de) 2008-12-11
EP1668001A1 (en) 2006-06-14
US20050119296A1 (en) 2005-06-02

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