BRPI0414570A - 2-pyridone derivatives as neutrophil elastase inhibitors and their use - Google Patents

2-pyridone derivatives as neutrophil elastase inhibitors and their use

Info

Publication number
BRPI0414570A
BRPI0414570A BRPI0414570-4A BRPI0414570A BRPI0414570A BR PI0414570 A BRPI0414570 A BR PI0414570A BR PI0414570 A BRPI0414570 A BR PI0414570A BR PI0414570 A BRPI0414570 A BR PI0414570A
Authority
BR
Brazil
Prior art keywords
elastase inhibitors
neutrophil elastase
pyridone derivatives
compounds
pyridone
Prior art date
Application number
BRPI0414570-4A
Other languages
Portuguese (pt)
Inventor
Peter Hansen
Karolina Lawitz
Hans Loenn
Antonios Nikitidis
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29212489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0414570(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0414570A publication Critical patent/BRPI0414570A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)

Abstract

"DERIVADOS DE 2-PIRIDONA COMO INIBIDORES DE ELASTASE DE NEUTRóFILO E SEU USO". A invenção provê novos compostos de fórmula (I) onde R¬ 1¬, R¬ 2¬, R¬ 4¬, R¬ 5¬, G¬ 1¬, G¬ 2¬, L, Y e n são como definidos no relatório descritivo, e isómeros óticos, racematos e tautómeros destes, e sais farmaceuticamente aceitáveis destes; juntamente com processos para sua preparação, composições os contendo e seu uso em terapia. Os compostos são inibidores da elastase de neutrófilo."2-PYRIDONE DERIVATIVES AS NEUTROPHYLE ELASTASE INHIBITORS AND THEIR USE". The invention provides novel compounds of formula (I) wherein R¬1¬, R¬2¬, R¬4¬, R¬5¬, G¬1¬, G¬2¬, L, Y and n are as defined in the report. descriptive, and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are neutrophil elastase inhibitors.

BRPI0414570-4A 2003-09-18 2004-09-15 2-pyridone derivatives as neutrophil elastase inhibitors and their use BRPI0414570A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0302487A SE0302487D0 (en) 2003-09-18 2003-09-18 Novel compounds
PCT/SE2004/001336 WO2005026124A1 (en) 2003-09-18 2004-09-15 2-pyridone derivatives as netrophil elastase inhibitors and their use

Publications (1)

Publication Number Publication Date
BRPI0414570A true BRPI0414570A (en) 2006-11-07

Family

ID=29212489

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414570-4A BRPI0414570A (en) 2003-09-18 2004-09-15 2-pyridone derivatives as neutrophil elastase inhibitors and their use

Country Status (25)

Country Link
US (1) US20070043036A1 (en)
EP (1) EP1663974B1 (en)
JP (1) JP2007505902A (en)
KR (1) KR20060096995A (en)
CN (1) CN100439339C (en)
AR (1) AR046083A1 (en)
AT (1) ATE420861T1 (en)
AU (1) AU2004272485B2 (en)
BR (1) BRPI0414570A (en)
CA (1) CA2538410A1 (en)
CO (1) CO5670357A2 (en)
DE (1) DE602004019110D1 (en)
ES (1) ES2319300T3 (en)
IL (1) IL173986A0 (en)
IS (1) IS8394A (en)
MX (1) MXPA06002723A (en)
NO (1) NO20061700L (en)
RU (1) RU2348617C2 (en)
SA (1) SA04250300B1 (en)
SE (1) SE0302487D0 (en)
TW (1) TW200526579A (en)
UA (1) UA84878C2 (en)
UY (1) UY28513A1 (en)
WO (1) WO2005026124A1 (en)
ZA (1) ZA200602262B (en)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
SE0302486D0 (en) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
TW200700392A (en) * 2005-03-16 2007-01-01 Astrazeneca Ab Novel compounds
ES2524922T3 (en) 2005-05-10 2014-12-15 Intermune, Inc. Pyridone derivatives to modulate the stress-activated protein kinase system
BRPI0614290A2 (en) 2005-08-08 2011-03-22 Argenta Discovery Ltd bicyclo [2.2.1] hept-7-ylamine derivatives and their uses
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
US20070104699A1 (en) * 2005-09-29 2007-05-10 University Of Alberta Compositions for and methods of granzyme B inhibition
GB0605469D0 (en) * 2006-03-17 2006-04-26 Argenta Discovery Ltd Multimers of heterocyclic compounds and their use
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
EP2077262A4 (en) 2006-10-23 2011-12-28 Takeda Pharmaceutical Iminopyridine derivative and use thereof
US7851489B2 (en) 2006-11-08 2010-12-14 Bristol-Myers Squibb Company Pyridinone compounds
WO2009061271A1 (en) 2007-11-06 2009-05-14 Astrazeneca Ab Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
PT2229358E (en) 2007-12-14 2011-06-29 Pulmagen Therapeutics Asthma Ltd Indoles and their therapeutic use
EA017736B1 (en) 2008-01-23 2013-02-28 Бристол-Маерс Сквибб Компани 4-pyridinone compounds and their use for cancer
US8481569B2 (en) 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
SG174134A1 (en) 2009-02-17 2011-10-28 Chiesi Farma Spa Triazolopyridine derivatives as p38 map kinase inhibitors
GB0902648D0 (en) 2009-02-17 2009-04-01 Argenta Discovery Ltd Pharmaceutical compounds and compositions
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
CA2773618A1 (en) * 2009-10-02 2011-04-07 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase
GB0918924D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Azaindole derivatives
GB0918922D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminopyridine derivatives
GB0918923D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminothiazole derivatives
CA2782384A1 (en) * 2009-12-08 2011-06-16 Boehringer Ingelheim International Gmbh Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds
GB201009731D0 (en) 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
CN104024241B (en) 2011-08-01 2016-01-20 大日本住友制药株式会社 Uracil derivatives and their use for medical purposes
BR112014013178A2 (en) 2011-12-09 2017-06-13 Chiesi Farm Spa compound, pharmaceutical composition and use of a compound
DK2788349T3 (en) 2011-12-09 2017-01-30 Chiesi Farm Spa kinase inhibitors
KR20140105459A (en) 2011-12-09 2014-09-01 키에시 파르마슈티시 엣스. 피. 에이. Kinase inhibitors
US9102624B2 (en) 2012-08-23 2015-08-11 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057926A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057920A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
AR092742A1 (en) 2012-10-02 2015-04-29 Intermune Inc ANTIFIBROTIC PYRIDINONES
RU2015151886A (en) 2013-06-06 2017-06-08 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. KINAZ INHIBITORS
US9221807B2 (en) 2014-02-21 2015-12-29 Boehringer Ingelheim International Gmbh Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity
MX382781B (en) 2014-04-02 2025-03-13 Intermune Inc ANTI-FIBROTIC PYRIDINONES.
HK1249504A1 (en) 2015-09-02 2018-11-02 Glaxosmithkline Intellectual Property (No. 2) Limited Pyridinone dicarboxamide for use as bromodomain inhibitors
TW201720828A (en) 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 Therapeutic compounds and compositions, and methods of use thereof
EP3394058B1 (en) 2015-12-23 2020-10-14 Chiesi Farmaceutici S.p.A. N-[3-(3-{4-[[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl} -ureido)-phenyl]-methanesulfonamide derivatives and their use as p38 mapk inhibitors
EP3394059B1 (en) 2015-12-23 2020-11-25 Chiesi Farmaceutici S.p.A. 1-(3-tert-butyl-phenyl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro- naphthalen-1-yl)-urea derivatives and their use as p38 mapk inhibitors
AR107164A1 (en) 2015-12-23 2018-03-28 Chiesi Farm Spa QUINASE P38 INHIBITORS
JP7034942B2 (en) 2016-05-05 2022-03-14 エフ．ホフマン－ラ ロシュ アーゲー Pyrazole derivatives, their compositions and therapeutic uses
CN109890817B (en) 2016-09-06 2022-06-17 豪夫迈·罗氏有限公司 8- (azetidin-1-yl) - [1,2,4] triazolo [1,5-a ] pyridinyl compounds, compositions, and methods of use thereof
EP3562809B1 (en) 2016-12-29 2021-06-09 F. Hoffmann-La Roche AG Pyrazolopyrimidine compounds and methods of use thereof
CN110494434B (en) 2017-03-14 2022-05-24 豪夫迈·罗氏有限公司 Pyrazolophenyl compounds, compositions thereof, and methods of use thereof
CN110678467B (en) 2017-05-22 2023-06-13 豪夫迈·罗氏有限公司 Therapeutic compounds and compositions and methods of use thereof
WO2018215389A1 (en) 2017-05-22 2018-11-29 F. Hoffmann-La Roche Ag Therapeutic compounds and compositions, and methods of use thereof
US10364245B2 (en) 2017-06-07 2019-07-30 Chiesi Farmaceutici S.P.A. Kinase inhibitors
EP3740488A1 (en) 2018-01-15 2020-11-25 F. Hoffmann-La Roche AG Pyrazolopyrimidine compounds as jak inhibitors
EP3749697A4 (en) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. CHROMATOGRAPHIC RESIN WITH A LIGAND WITH ANION EXCHANGE-HYDROPHOBIC MIXED MODE
CN110192948B (en) * 2019-05-28 2022-01-04 河南省超亚医药器械有限公司 Infant abdomen hot compress patch
CN110192947B (en) * 2019-05-28 2022-01-04 河南省超亚医药器械有限公司 Infant lung hot compress patch
US20200399274A1 (en) 2019-06-18 2020-12-24 Genentech, Inc. Tetrazole-substituted pyrazolopyrimidine inhibitors of jak kinases and uses thereof
CA3140024A1 (en) 2019-06-18 2020-12-24 Mark Edward Zak Pyrazolopyrimidine sulfone inhibitors of jak kinases and uses thereof
WO2020257143A1 (en) 2019-06-18 2020-12-24 Genentech, Inc. Pyrazolopyrimidine aryl ether inhibitors of jak kinases and uses thereof
CN114650819A (en) 2019-09-17 2022-06-21 美莱奥生物制药第四有限公司 Avermectistat for treating graft rejection, bronchiolitis obliterans syndrome and graft-versus-host disease
WO2021209740A1 (en) 2020-04-16 2021-10-21 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating coronavirus infection
EP4419102A1 (en) 2021-10-20 2024-08-28 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis
CN114057630B (en) * 2021-12-23 2023-06-02 郑州大学 Pirfenidone derivatives and their synthetic methods and applications

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9207145D0 (en) * 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides
US5521179A (en) * 1991-04-18 1996-05-28 Zeneca Limited Heterocyclic amides
FR2687674B1 (en) * 1992-02-07 1995-05-19 Roussel Uclaf NEW PYRIDONE DERIVATIVES, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE69433705T2 (en) * 1993-11-19 2005-03-10 Parke, Davis & Company 5,6-Dihydropyrone derivatives as protease inhibitors and antiviral agents
RU2067579C1 (en) * 1994-10-07 1996-10-10 Пермский фармацевтический институт 3-(2'-naphthoylmethylene)-piperazinone-2 and 1-n-phenyl-3-phenacylidenepiperazinone-2 showing antiinflammatory activity
ES2330719T3 (en) * 2000-12-28 2009-12-15 SHIONOGI & CO., LTD. DERIVATIVES OF 2-PIRIDONE WITH AFFINITY FOR THE CANNABINOID RECEIVER TYPE 2.
GB0129260D0 (en) * 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
DE60214428T2 (en) * 2001-12-20 2007-09-20 Bayer Healthcare Ag 1, 4-DIHYDRO-1, 4-DIPHENYLPYRIDINE DERIVATIVES
GB2383326A (en) * 2001-12-20 2003-06-25 Bayer Ag Antiinflammatory dihydropyridines
TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
SE0302486D0 (en) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
IL173986A0 (en) 2006-07-05
RU2006112427A (en) 2007-11-10
ES2319300T3 (en) 2009-05-06
ZA200602262B (en) 2007-07-25
EP1663974B1 (en) 2009-01-14
CN1856467A (en) 2006-11-01
CA2538410A1 (en) 2005-03-24
DE602004019110D1 (en) 2009-03-05
AR046083A1 (en) 2005-11-23
SE0302487D0 (en) 2003-09-18
NO20061700L (en) 2006-04-18
RU2348617C2 (en) 2009-03-10
SA04250300B1 (en) 2008-09-07
UA84878C2 (en) 2008-12-10
UY28513A1 (en) 2005-04-29
ATE420861T1 (en) 2009-01-15
KR20060096995A (en) 2006-09-13
IS8394A (en) 2006-03-31
CN100439339C (en) 2008-12-03
AU2004272485B2 (en) 2008-03-13
EP1663974A1 (en) 2006-06-07
WO2005026124A1 (en) 2005-03-24
MXPA06002723A (en) 2006-06-06
US20070043036A1 (en) 2007-02-22
AU2004272485A1 (en) 2005-03-24
TW200526579A (en) 2005-08-16
CO5670357A2 (en) 2006-08-31
HK1089167A1 (en) 2006-11-24
JP2007505902A (en) 2007-03-15

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.