BRPI0414982A - dispositivo e método para produção de partìculas - Google Patents

dispositivo e método para produção de partìculas

Info

Publication number
BRPI0414982A
BRPI0414982A BRPI0414982-3A BRPI0414982A BRPI0414982A BR PI0414982 A BRPI0414982 A BR PI0414982A BR PI0414982 A BRPI0414982 A BR PI0414982A BR PI0414982 A BRPI0414982 A BR PI0414982A
Authority
BR
Brazil
Prior art keywords
particle production
production device
feed
inlet
discharge
Prior art date
Application number
BRPI0414982-3A
Other languages
English (en)
Inventor
Catherine Curdy
Bertrand Ducrey
Frederic Heimgartner
Francois Pfefferle
Original Assignee
Debio Rech Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debio Rech Pharma Sa filed Critical Debio Rech Pharma Sa
Publication of BRPI0414982A publication Critical patent/BRPI0414982A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • B01F27/2711—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • B01F25/3131—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit with additional mixing means other than injector mixers, e.g. screens, baffles or rotating elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71825—Feed mechanisms characterised by the means for feeding the components to the mixer using means for feeding one phase surrounded by another phase without mixing during the feeding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/753—Discharging at the upper side of the receptacle, e.g. by pressurising the liquid in the receptacle or by centrifugal force
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Colloid Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)

Abstract

"DISPOSITIVO E MéTODO PARA PRODUçãO DE PARTìCULAS". Dispositivo para produzir continuamente partículas, consistindo de um compartimento de homogeneização (1) incluindo pelo menos uma admissão (2) para alimentação em uma fase orgânica, uma admissão (3) para alimentação em uma fase aquosa, um sistema de mistura (4) e uma descarga (5).
BRPI0414982-3A 2003-10-01 2004-09-28 dispositivo e método para produção de partìculas BRPI0414982A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH16642003 2003-10-01
PCT/IB2004/003151 WO2005032703A1 (fr) 2003-10-01 2004-09-28 Dispositif et procede pour la fabrication de particules

Publications (1)

Publication Number Publication Date
BRPI0414982A true BRPI0414982A (pt) 2006-11-21

Family

ID=34398333

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414982-3A BRPI0414982A (pt) 2003-10-01 2004-09-28 dispositivo e método para produção de partìculas

Country Status (16)

Country Link
US (1) US20070071825A1 (pt)
EP (1) EP1667790B1 (pt)
JP (1) JP2007507339A (pt)
KR (1) KR20060104989A (pt)
CN (1) CN100534597C (pt)
AT (1) ATE362395T1 (pt)
AU (1) AU2004277750B9 (pt)
BR (1) BRPI0414982A (pt)
CA (1) CA2539303C (pt)
DE (1) DE602004006523T2 (pt)
DK (1) DK1667790T3 (pt)
ES (1) ES2286674T3 (pt)
IL (1) IL174668A (pt)
MX (1) MXPA06003599A (pt)
WO (1) WO2005032703A1 (pt)
ZA (1) ZA200603365B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2060253A1 (en) * 2007-11-14 2009-05-20 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
CN101106972A (zh) * 2004-11-16 2008-01-16 伊兰制药国际有限公司 注射用纳米微粒奥氮平制剂
EP1830824B1 (en) * 2004-12-31 2016-01-13 Iceutica Pty Ltd. Nanoparticle composition and methods for synthesis thereof
ES2371678T3 (es) * 2006-03-13 2012-01-09 Basf Se Método para la producción de nanopartículas poliméricas.
US20070298110A1 (en) * 2006-06-22 2007-12-27 Xerox Corporation Methods for embedding nanoparticles
AU2007264418B2 (en) 2006-06-30 2012-05-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
EP2063970A1 (en) * 2006-09-19 2009-06-03 FUJIFILM Manufacturing Europe B.V. Preparation of fine particles
WO2008035962A1 (en) * 2006-09-19 2008-03-27 Fujifilm Manufacturing Europe B.V. Process and device for the precipitation of an organic compound
JP5076424B2 (ja) 2006-09-28 2012-11-21 日油株式会社 撹拌処理方法及び撹拌装置
GB0714223D0 (en) * 2007-07-20 2007-08-29 Fujifilm Mfg Europe Bv Preparation of fine particles
EP2213282A1 (en) * 2009-01-30 2010-08-04 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
US8802156B2 (en) 2007-11-14 2014-08-12 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
CA2730760A1 (en) * 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles containing bioactive peptides
CN101530778B (zh) * 2009-03-09 2011-05-11 神农氏奈米科技有限公司 液体纳米化装置
CN102438594A (zh) 2009-04-24 2012-05-02 伊休蒂卡有限公司 吲哚美辛的新剂型
CA2784287C (en) * 2009-12-22 2017-07-18 Evonik Degussa Corporation Emulsion-based process for preparing microparticles and workhead assembly for use with same
MY181812A (en) 2010-01-20 2021-01-07 Xyleco Inc Dispersing feedstocks and processing materials
ES2985784T3 (es) 2011-11-18 2024-11-07 Regeneron Pharma Micropartículas de proteínas recubiertas con polímeros para formulaciones de liberación prolongada para su uso en el humor vítreo del ojo para tratar trastornos oculares vasculares
CN103521149B (zh) * 2013-10-10 2015-11-04 南京理工大学 含能高分子微球的制备方法
CN104549078B (zh) * 2013-10-10 2016-11-23 南京理工大学 一种开孔结构含能高分子微球的制备方法
CN103553853B (zh) * 2013-11-01 2016-04-20 南京理工大学 水溶性氧化剂在含能复合材料中的原位超细化分散方法
CN103787799B (zh) * 2014-01-22 2016-07-06 南京理工大学 含能高分子微球的连续制备系统及方法
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
CN106475574B (zh) * 2016-11-30 2018-06-08 燕山大学 一种制备金纳米花的方法
CN112587505A (zh) * 2020-10-16 2021-04-02 长春斯菲尔生物科技有限公司 一种奥氮平双羟萘酸盐缓释微粒制剂及其制备方法
US20220362323A1 (en) * 2021-05-02 2022-11-17 Kula Llc Systems and methods for producing a kava liquid dietary supplement
US11801514B1 (en) 2023-02-10 2023-10-31 CR Nano, Inc. Mechanochemical production of tunable planar materials
EP4732949A1 (en) * 2023-06-22 2026-04-29 Tantti Laboratory Inc. Micro-droplet production device and method
AR133300A1 (es) * 2023-07-20 2025-09-17 Ferring Bv Micropartículas cargadas con fármaco de liberación prolongada
TW202529795A (zh) * 2023-11-08 2025-08-01 瑞士商戴比歐醫藥國際公司 新穎組成物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2641453A (en) * 1951-04-21 1953-06-09 Nat Gypsum Co Pin mixer
JPS5323382B2 (pt) * 1972-07-03 1978-07-14
DE2516561C3 (de) * 1975-04-16 1979-10-11 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Fibrillen aus Polymerisaten
US4141957A (en) * 1976-06-29 1979-02-27 Isovolta Osterreichische Isolierstoffwerke Aktiengesellschaft Apparatus for producing polymers of high molecular weight by the two-phase interfacial method
SE445052C (sv) * 1980-03-13 1987-11-09 Sunds Defibrator Sett och anordning for kontinuerlig inblandning av gas- och/eller vetskeformiga behandlingsmedel i en massasuspension
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
FI61814C (fi) * 1980-07-22 1982-10-11 Finnreg Oy Emulgeringsanordning
CA2063441C (en) * 1989-06-30 2000-05-16 Ioannis Scarpa Cellulose chromatography support
WO1993010665A1 (en) * 1991-12-03 1993-06-10 Niro A/S Process for producing a solid water-in-oil emulsion and an apparatus for carrying out the process
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
AU668062B2 (en) * 1994-03-07 1996-04-18 Morton International, Inc. Polyester dispersions, method of preparation
ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
DE19616010C2 (de) * 1996-04-23 1998-07-09 Seitz Filter Werke Verfahren und Vorrichtung zur Herstellung von Fibrets (Fibriden) aus Zellulosederivaten
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
JP3255072B2 (ja) * 1997-02-17 2002-02-12 日本ピー・エム・シー株式会社 ロジン系物質の水性エマルションの製造方法、その水性エマルション組成物及びサイズ剤
JP4587111B2 (ja) * 2000-04-06 2010-11-24 栗田工業株式会社 オゾン溶解水供給装置
DE60210794T2 (de) * 2001-10-17 2007-05-10 E.I. Dupont De Nemours And Co., Wilmington Rotor-stator apparat und verfahren zur bildung von partikeln

Also Published As

Publication number Publication date
AU2004277750A1 (en) 2005-04-14
ATE362395T1 (de) 2007-06-15
KR20060104989A (ko) 2006-10-09
US20070071825A1 (en) 2007-03-29
ES2286674T3 (es) 2007-12-01
CA2539303C (fr) 2012-07-17
AU2004277750B9 (en) 2010-07-15
MXPA06003599A (es) 2006-06-20
IL174668A0 (en) 2006-08-20
CN100534597C (zh) 2009-09-02
WO2005032703A1 (fr) 2005-04-14
CA2539303A1 (fr) 2005-04-14
DE602004006523T2 (de) 2008-01-31
AU2004277750B2 (en) 2010-03-11
IL174668A (en) 2010-12-30
EP1667790B1 (fr) 2007-05-16
JP2007507339A (ja) 2007-03-29
CN1863588A (zh) 2006-11-15
DK1667790T3 (da) 2007-09-24
ZA200603365B (en) 2007-07-25
EP1667790A1 (fr) 2006-06-14
DE602004006523D1 (de) 2007-06-28

Similar Documents

Publication Publication Date Title
BRPI0414982A (pt) dispositivo e método para produção de partìculas
GB2399084B (en) Porous beads and method of production thereof
WO2004007172A8 (en) Process and apparatus for continuously producing an elatomeric composition
MXPA05010045A (es) Metodos y aparatos para la fragmentacion y estabilizacion de particulas pequenas.
BRPI0517091B8 (pt) composto 4-hidroxibenzomorfano substituído na posição-3 por carboxamida ou tiocarboxamida
ATE445386T1 (de) Polymerische parfümpartikel
BR0316403A (pt) Processo para a produção de um pó de borracha a partir de um material de borracha vulcanizada
WO2006023357A8 (en) A method, system, and computer program product for ranking of documents using link analysis, with remedies for sinks
CO5670354A2 (es) Proceso para la elaboracion de aripiprazol esteril de tamaño particula promedio deseado
FR2804119B1 (fr) Procede de preparation de melanges-maitres a base de polymere et de particules minerales et melanges-maitres ainsi obtenus
WO2005070046A3 (en) Mixing apparatus and method for manufacturing an emulsified fuel
MXPA06002349A (es) Derivados de aminopropanol.
BRPI0409223A (pt) lixiviação amoniacal redutiva de materiais de transporte de nìquel e cobalto
BRPI0718145B1 (pt) método de micronização
EP1600207A4 (en) EMULSIFIER, METHOD FOR THE PRODUCTION THEREOF AND THE EMULSIFIED EMULSIFIED COMPOSITION
WO2007051169A3 (en) Use of b cell expansion agents in generating antibodies
SE0303476D0 (sv) Device, method and use for the formation of small particles
DE602006015393D1 (de) Brennstoffzellensystem und Vorrichtung für die Zufuhr von Mischbrennstoff und Wasser
DE602005018233D1 (de) Verfahren und vorrichtung zur einspeisung einer chemikalie in einen flüssigkeitsstrom
WO2005042408A3 (en) Treatment of particle-bearing liquid
ATE421513T1 (de) Benzopyranderivate, die mit sekundären aminen einschliesslich tetrazol substituiert sind, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
BRPI0411134A (pt) aparelho e método para produzir sorvete tradicional e partìculas combinadas
ATE358530T1 (de) Vorrichtung zum mischen von orthopädie-zement
TW200606704A (en) Processing of documents with medical and other waste
SG128490A1 (en) Process for forming dispersant-coated carbon particles

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2261 DE 06/05/2014.