BRPI0415661A - uso de um composto, composição farmacêutica, e, composto - Google Patents

uso de um composto, composição farmacêutica, e, composto

Info

Publication number
BRPI0415661A
BRPI0415661A BRPI0415661-7A BRPI0415661A BRPI0415661A BR PI0415661 A BRPI0415661 A BR PI0415661A BR PI0415661 A BRPI0415661 A BR PI0415661A BR PI0415661 A BRPI0415661 A BR PI0415661A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
agonists
receptor
thiazol
Prior art date
Application number
BRPI0415661-7A
Other languages
English (en)
Inventor
Anette Graven Sams
Mogens Larsen
Gitte Mikkelsen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BRPI0415661A publication Critical patent/BRPI0415661A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"USO DE UM COMPOSTO, COMPOSIçãO FARMACêUTICA, E, COMPOSTO". A invenção refere-se aos derivados de N-tiazol-2-il-benzamida de fórmula I na descrição na qual as variáveis são como definidas nas reivindicações. Os compostos são ligantes de receptor de A~ 2A~, tais como antagonistas, agonistas, agonistas reversos ou agonistas parciais, e são úteis no tratamento de distúrbios neurológicos e psiquiátricos onde um receptor de A~ 2A~ está implicado.
BRPI0415661-7A 2003-10-27 2004-10-25 uso de um composto, composição farmacêutica, e, composto BRPI0415661A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200301579 2003-10-27
DKPA200400229 2004-02-13
PCT/DK2004/000733 WO2005039572A1 (en) 2003-10-27 2004-10-25 N-thiazol-2-yl-benzamide derivatives

Publications (1)

Publication Number Publication Date
BRPI0415661A true BRPI0415661A (pt) 2006-12-19

Family

ID=34524309

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415661-7A BRPI0415661A (pt) 2003-10-27 2004-10-25 uso de um composto, composição farmacêutica, e, composto

Country Status (28)

Country Link
US (2) US20060154974A1 (pt)
EP (2) EP1682129B1 (pt)
JP (1) JP2007509083A (pt)
KR (1) KR20060093726A (pt)
AR (1) AR047621A1 (pt)
AT (1) ATE354365T1 (pt)
AU (1) AU2004283019A1 (pt)
BR (1) BRPI0415661A (pt)
CA (1) CA2542816A1 (pt)
CO (1) CO5690582A2 (pt)
CY (1) CY1106526T1 (pt)
DE (1) DE602004004925T2 (pt)
DK (1) DK1682129T3 (pt)
EA (2) EA010790B1 (pt)
ES (1) ES2279414T3 (pt)
HR (1) HRP20070194T3 (pt)
IL (1) IL175189A0 (pt)
IS (1) IS8364A (pt)
ME (1) MEP6708A (pt)
MX (1) MXPA06004436A (pt)
NO (1) NO20062417L (pt)
PL (1) PL1682129T3 (pt)
PT (1) PT1682129E (pt)
RS (1) RS20060289A (pt)
SG (1) SG147472A1 (pt)
SI (1) SI1682129T1 (pt)
TW (1) TW200524887A (pt)
WO (1) WO2005039572A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060106040A1 (en) 2002-12-19 2006-05-18 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
TW200524887A (en) * 2003-10-27 2005-08-01 Lundbeck & Co As H N-thiazol-2-yl-benzamide derivatives
US7910613B2 (en) 2004-09-22 2011-03-22 H. Lundbeck A/S 2-acylaminothiazole derivatives
US7674912B2 (en) 2005-04-25 2010-03-09 H. Lundbeck A/S Pro-drugs of N-thiazol-2-yl-benzamide derivatives
TW200720264A (en) * 2005-04-25 2007-06-01 Lundbeck & Co As H Pro-drugs of n-thiazol-2-yl-benzamide derivatives
WO2006137527A1 (ja) 2005-06-23 2006-12-28 Kyowa Hakko Kogyo Co., Ltd. チアゾール誘導体
DK1921077T3 (en) * 2005-08-02 2017-10-23 Kyowa Hakko Kirin Co Ltd Means for treating and / or preventing sleep disorders
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
EP2210891A1 (en) * 2009-01-26 2010-07-28 Domain Therapeutics New adenosine receptor ligands and uses thereof
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
RU2483722C1 (ru) * 2012-05-22 2013-06-10 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Аминотиазольные производные усниновой кислоты как новые противотуберкулезные агенты
GB201218850D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
GB201218864D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
US9980973B2 (en) 2012-10-19 2018-05-29 Astex Therapeutics Limited Bicyclic heterocycle compounds and their uses in therapy
GB201218862D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
ES2883289T3 (es) 2013-12-20 2021-12-07 Astex Therapeutics Ltd Compuestos heterocíclicos bicíclicos y sus usos en terapia
ES2578363B1 (es) * 2015-01-22 2017-01-31 Palobiofarma, S.L. Moduladores de los receptores A3 de adenosina

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE855120C (de) * 1950-10-08 1953-01-05 Schering Ag Verfahren zur Herstellung von Aminosalicylsaeureamiden
JP2903339B2 (ja) * 1990-10-12 1999-06-07 大日精化工業株式会社 電子写真感光体
JP4153043B2 (ja) * 1996-10-24 2008-09-17 ゼリア新薬工業株式会社 置換ベンゾイルアミノチアゾール誘導体及びそれを含有する医薬
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
GB0028383D0 (en) * 2000-11-21 2001-01-03 Novartis Ag Organic compounds
KR20040025891A (ko) * 2001-01-26 2004-03-26 시오노기세이야쿠가부시키가이샤 트롬보포이에틴 수용체 효현작용을 갖는 할로겐 화합물
US7429593B2 (en) * 2001-09-14 2008-09-30 Shionogi & Co., Ltd. Utilities of amide compounds
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
US6713499B2 (en) * 2001-12-12 2004-03-30 Hoffman-La Roche Inc. 7-Amino-benzothiazole derivatives
TW200524887A (en) * 2003-10-27 2005-08-01 Lundbeck & Co As H N-thiazol-2-yl-benzamide derivatives
CA2551611C (en) * 2003-12-26 2013-06-25 Kyowa Kirin Co., Ltd. Thiazole derivatives for treating or preventing parkinson's disease
US7674912B2 (en) * 2005-04-25 2010-03-09 H. Lundbeck A/S Pro-drugs of N-thiazol-2-yl-benzamide derivatives

Also Published As

Publication number Publication date
EA200600860A1 (ru) 2006-08-25
US20090247593A1 (en) 2009-10-01
ES2279414T3 (es) 2007-08-16
RS20060289A (sr) 2008-06-05
PL1682129T3 (pl) 2007-07-31
DE602004004925T2 (de) 2007-10-31
MXPA06004436A (es) 2006-06-20
DE602004004925D1 (de) 2007-04-05
IL175189A0 (en) 2006-09-05
KR20060093726A (ko) 2006-08-25
WO2005039572A1 (en) 2005-05-06
US20060154974A1 (en) 2006-07-13
EP1803455A1 (en) 2007-07-04
DK1682129T3 (da) 2007-06-11
TW200524887A (en) 2005-08-01
JP2007509083A (ja) 2007-04-12
CA2542816A1 (en) 2005-05-06
NO20062417L (no) 2006-05-26
SG147472A1 (en) 2008-11-28
CY1106526T1 (el) 2012-01-25
EP1682129B1 (en) 2007-02-21
AU2004283019A1 (en) 2005-05-06
MEP6708A (xx) 2010-02-10
PT1682129E (pt) 2007-04-30
HRP20070194T3 (hr) 2007-06-30
IS8364A (is) 2006-03-20
ATE354365T1 (de) 2007-03-15
CO5690582A2 (es) 2006-10-31
EP1682129A1 (en) 2006-07-26
SI1682129T1 (sl) 2007-06-30
EA200801734A1 (ru) 2008-12-30
EA010790B1 (ru) 2008-10-30
AR047621A1 (es) 2006-02-01

Similar Documents

Publication Publication Date Title
BRPI0415661A (pt) uso de um composto, composição farmacêutica, e, composto
BR0306150A (pt) Composto, uso de um composto, e, composição farmacêutica
EA200201119A1 (ru) Лиганды меланокортиновых рецепторов
EA200500342A1 (ru) Гетероциклические замещённые пиперазины для лечения шизофрении
ATE384050T1 (de) Benzazepinderivate als histamin-h3-antagonisten
ECSP034797A (es) DERIVADOS DIHIDRO-BENZO[b][1,4]DIAZEPIN-2-ONA COMO ANTAGONISTAS II MGLUR2
EP1622616A4 (en) HEMMER OF ACT ACTIVITY
DK1337518T3 (da) Piperazinylpyrazinforbindelser som antagonister for serotonin-5-HT2-receptoren
BR0116452A (pt) Composto, composição farmacêutica, uso de um composto
EA200300829A1 (ru) Производные 1-арил- или 1-алкилсульфонилбензазола в качестве лигандов 5-гидрокситриптамина-6
NO20060154L (no) Imidazolyl-derivater
BRPI0612141A2 (pt) derivados de quinuclidina substituìdos com biciclo-heterociclos fundidos
EA200100972A1 (ru) Новые соединения и композиции как ингибиторы протеаз
DE60131967D1 (de) Nr1h4-kern-rezeptor-bindende verbindungen
EP1558586A4 (en) HEMMER OF ACT ACTIVITY
EA199900693A1 (ru) Атропизомеры 3-арил-4(3h)-хиназолинонов и их использование в качестве антагонистов амра-рецепторов
EA200300171A1 (ru) Циклопентаноиндолы, композиции, содержащие данные соединения, и способы лечения
BR0013041A (pt) Composto heterociclico e composição farmacêutica para tratar e prevenir doenças mediadas por cgmp-pde, seu uso e método
ECSP024403A (es) Derivados de sulfonil-pirrolidina utiles para el tratamiento de desordenes neurologicos
BR0009278A (pt) 1-arenossulfonil-2-aril-pirrolidina e derivados depiperidina
BRPI0418255A (pt) derivados de piperazina e piperidina n-substituìdos
BRPI0407841A (pt) inibidores heterocìclicos de quinase
EA200100516A1 (ru) Производные 3,3-биарилпиперидина и 2,2-биарилморфолина
EA200301143A1 (ru) Производные гетероциклилалкокси-, алкилтио- и -алкиламинобензазола в качестве лигандов 5-гидрокситриптамина-6
CY1105039T1 (el) ΥΠΟΚΑΤΕΣΤΗΜΕΝΕΣ ΕΝΩΣΕΙΣ ΒΕΝΖΟ[b]ΑΖΕΠΙΝ-2-ΟΝΗΣ

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.