BRPI0415779A - tratamento de doenças proliferativas usando um oligÈmero antisenso iap e um agente quimioterápico - Google Patents

tratamento de doenças proliferativas usando um oligÈmero antisenso iap e um agente quimioterápico

Info

Publication number
BRPI0415779A
BRPI0415779A BRPI0415779-6A BRPI0415779A BRPI0415779A BR PI0415779 A BRPI0415779 A BR PI0415779A BR PI0415779 A BRPI0415779 A BR PI0415779A BR PI0415779 A BRPI0415779 A BR PI0415779A
Authority
BR
Brazil
Prior art keywords
treatment
proliferative diseases
chemotherapeutic agent
antisense oligomer
iap antisense
Prior art date
Application number
BRPI0415779-6A
Other languages
English (en)
Inventor
Eric Lacasse
Daniel Mcmanus
Jon P Durkin
Original Assignee
Aegera Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aegera Therapeutics Inc filed Critical Aegera Therapeutics Inc
Publication of BRPI0415779A publication Critical patent/BRPI0415779A/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/30—Chemical structure
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biomedical Technology (AREA)
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  • Biochemistry (AREA)
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  • Biophysics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"TRATAMENTO DE DOENçAS PROLIFERATIVAS USANDO UM OLIGÈMERO ANTISENSO IAP E UM AGENTE QUIMIOTERáPICO". O presente invento apresenta o uso de um oligómero antisenso para XIAP, HIAP-1 ou HIAP-2 e um agente quimioterapêutico, e suas composições e seus kits, para o tratamento de doenças proliferativas.
BRPI0415779-6A 2003-10-30 2004-10-29 tratamento de doenças proliferativas usando um oligÈmero antisenso iap e um agente quimioterápico BRPI0415779A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51626303P 2003-10-30 2003-10-30
PCT/CA2004/001900 WO2005042030A1 (en) 2003-10-30 2004-10-29 Treatment of proliferative diseases using an antisense iap oligomer and chemotherapeutic agent

Publications (1)

Publication Number Publication Date
BRPI0415779A true BRPI0415779A (pt) 2006-12-26

Family

ID=34549513

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415779-6A BRPI0415779A (pt) 2003-10-30 2004-10-29 tratamento de doenças proliferativas usando um oligÈmero antisenso iap e um agente quimioterápico

Country Status (17)

Country Link
US (1) US8012944B2 (pt)
EP (1) EP1691842A4 (pt)
JP (1) JP2007509861A (pt)
KR (1) KR20060127393A (pt)
CN (2) CN101862459A (pt)
AU (1) AU2004284855A1 (pt)
BR (1) BRPI0415779A (pt)
CA (1) CA2542884A1 (pt)
IL (1) IL175242A0 (pt)
MX (1) MXPA06004920A (pt)
NO (1) NO20062420L (pt)
NZ (1) NZ547191A (pt)
RU (2) RU2376018C2 (pt)
SG (1) SG157422A1 (pt)
TW (1) TWI332841B (pt)
WO (1) WO2005042030A1 (pt)
ZA (1) ZA200603399B (pt)

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RU2010101234A (ru) 2011-07-20
AU2004284855A1 (en) 2005-05-12
CN101862459A (zh) 2010-10-20
CA2542884A1 (en) 2005-05-12
IL175242A0 (en) 2006-09-05
TWI332841B (en) 2010-11-11
WO2005042030A1 (en) 2005-05-12
KR20060127393A (ko) 2006-12-12
JP2007509861A (ja) 2007-04-19
TW200528117A (en) 2005-09-01
NO20062420L (no) 2006-07-31
NZ547191A (en) 2009-08-28
ZA200603399B (en) 2007-09-26
US20050119217A1 (en) 2005-06-02
RU2376018C2 (ru) 2009-12-20
EP1691842A1 (en) 2006-08-23
US8012944B2 (en) 2011-09-06
SG157422A1 (en) 2009-12-29
MXPA06004920A (es) 2007-02-16
EP1691842A4 (en) 2008-06-11
RU2006117024A (ru) 2007-12-10

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