BRPI0416044A - sistema e método para distribuição transdérmica - Google Patents

sistema e método para distribuição transdérmica

Info

Publication number
BRPI0416044A
BRPI0416044A BRPI0416044-4A BRPI0416044A BRPI0416044A BR PI0416044 A BRPI0416044 A BR PI0416044A BR PI0416044 A BRPI0416044 A BR PI0416044A BR PI0416044 A BRPI0416044 A BR PI0416044A
Authority
BR
Brazil
Prior art keywords
electrical signal
agent
transdermal
electrodes
transdermal delivery
Prior art date
Application number
BRPI0416044-4A
Other languages
English (en)
Inventor
Subramony Janardhanan
Georg Widera
Joseph B Phipps
Michael Cormier
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0416044A publication Critical patent/BRPI0416044A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"SISTEMA E MéTODO PARA DISTRIBUIçãO TRANSDéRMICA". Sistema e método para distribuição transdérmica de um agente biologicamente ativo compreendendo um ou mais eletrodos tendo projeções que perfuram o stratum corneum e um circuito que distribui um sinal elétrico aos eletrodos para eletroporar uma membrana celular. De preferência, o sistema é configurado para gerar campos elétricos homogêneos e, mais preferivelmente, para gerar campos elétricos esférica ou semi-esfericamente simétricos. Os métodos da invenção incluem aplicação de um primeiro sinal elétrico para facilitar o transporte transdérmico do agente e aplicação de um segundo sinal elétrico para facilitar o transporte intracelular do agente.
BRPI0416044-4A 2003-11-13 2004-11-01 sistema e método para distribuição transdérmica BRPI0416044A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52004303P 2003-11-13 2003-11-13
PCT/US2004/036180 WO2005049108A2 (en) 2003-11-13 2004-11-01 System and method for transdermal delivery

Publications (1)

Publication Number Publication Date
BRPI0416044A true BRPI0416044A (pt) 2007-01-02

Family

ID=34619420

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416044-4A BRPI0416044A (pt) 2003-11-13 2004-11-01 sistema e método para distribuição transdérmica

Country Status (12)

Country Link
US (1) US20060036209A1 (pt)
EP (1) EP1682217A4 (pt)
JP (1) JP2007526794A (pt)
KR (1) KR20070011240A (pt)
CN (1) CN1905920A (pt)
AR (1) AR047039A1 (pt)
AU (1) AU2004291040A1 (pt)
BR (1) BRPI0416044A (pt)
CA (1) CA2546282A1 (pt)
MX (1) MXPA06005509A (pt)
TW (1) TW200526286A (pt)
WO (1) WO2005049108A2 (pt)

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KR20070011240A (ko) 2007-01-24
TW200526286A (en) 2005-08-16
EP1682217A4 (en) 2008-04-30
EP1682217A2 (en) 2006-07-26
CN1905920A (zh) 2007-01-31
MXPA06005509A (es) 2007-05-23
WO2005049108A2 (en) 2005-06-02
US20060036209A1 (en) 2006-02-16
AR047039A1 (es) 2006-01-04
CA2546282A1 (en) 2005-06-02
WO2005049108A3 (en) 2006-05-18

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