BRPI0416044A - sistema e método para distribuição transdérmica - Google Patents

sistema e método para distribuição transdérmica

Info

Publication number
BRPI0416044A
BRPI0416044A BRPI0416044-4A BRPI0416044A BRPI0416044A BR PI0416044 A BRPI0416044 A BR PI0416044A BR PI0416044 A BRPI0416044 A BR PI0416044A BR PI0416044 A BRPI0416044 A BR PI0416044A
Authority
BR
Brazil
Prior art keywords
electrical signal
agent
transdermal
electrodes
transdermal delivery
Prior art date
Application number
BRPI0416044-4A
Other languages
English (en)
Inventor
Subramony Janardhanan
Georg Widera
Joseph B Phipps
Michael Cormier
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0416044A publication Critical patent/BRPI0416044A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

"SISTEMA E MéTODO PARA DISTRIBUIçãO TRANSDéRMICA". Sistema e método para distribuição transdérmica de um agente biologicamente ativo compreendendo um ou mais eletrodos tendo projeções que perfuram o stratum corneum e um circuito que distribui um sinal elétrico aos eletrodos para eletroporar uma membrana celular. De preferência, o sistema é configurado para gerar campos elétricos homogêneos e, mais preferivelmente, para gerar campos elétricos esférica ou semi-esfericamente simétricos. Os métodos da invenção incluem aplicação de um primeiro sinal elétrico para facilitar o transporte transdérmico do agente e aplicação de um segundo sinal elétrico para facilitar o transporte intracelular do agente.
BRPI0416044-4A 2003-11-13 2004-11-01 sistema e método para distribuição transdérmica BRPI0416044A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52004303P 2003-11-13 2003-11-13
PCT/US2004/036180 WO2005049108A2 (en) 2003-11-13 2004-11-01 System and method for transdermal delivery

Publications (1)

Publication Number Publication Date
BRPI0416044A true BRPI0416044A (pt) 2007-01-02

Family

ID=34619420

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416044-4A BRPI0416044A (pt) 2003-11-13 2004-11-01 sistema e método para distribuição transdérmica

Country Status (12)

Country Link
US (1) US20060036209A1 (pt)
EP (1) EP1682217A4 (pt)
JP (1) JP2007526794A (pt)
KR (1) KR20070011240A (pt)
CN (1) CN1905920A (pt)
AR (1) AR047039A1 (pt)
AU (1) AU2004291040A1 (pt)
BR (1) BRPI0416044A (pt)
CA (1) CA2546282A1 (pt)
MX (1) MXPA06005509A (pt)
TW (1) TW200526286A (pt)
WO (1) WO2005049108A2 (pt)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US9302903B2 (en) * 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
JP5254616B2 (ja) 2004-09-13 2013-08-07 クロノ セラピューティクス、インコーポレイテッド 生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達
US20060095001A1 (en) * 2004-10-29 2006-05-04 Transcutaneous Technologies Inc. Electrode and iontophoresis device
JP2006346368A (ja) * 2005-06-20 2006-12-28 Transcutaneous Technologies Inc イオントフォレーシス装置及びその製造方法
JP2007037868A (ja) * 2005-08-05 2007-02-15 Transcutaneous Technologies Inc 経皮投与装置及びその制御方法
US8386030B2 (en) * 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
US20070060860A1 (en) * 2005-08-18 2007-03-15 Transcutaneous Technologies Inc. Iontophoresis device
JPWO2007026671A1 (ja) * 2005-08-29 2009-03-05 Ｔｔｉ・エルビュー株式会社 センサからの情報により投与すべき薬剤の選定を行うイオントフォレーシス装置
JPWO2007029611A1 (ja) * 2005-09-06 2009-03-19 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
EP1925336A4 (en) * 2005-09-15 2011-01-19 Tti Ellebeau Inc ROD TYPE IONTOPHORESIS APPARATUS
KR20080056200A (ko) * 2005-09-16 2008-06-20 티티아이 엘뷰 가부시키가이샤 카테터형 이온토포레시스 장치
US20070260171A1 (en) * 2005-09-27 2007-11-08 Higuchi John W Intraocular iontophoretic device and associated methods
US8755880B2 (en) * 2005-10-24 2014-06-17 Aciont, Inc. Intraocular iontophoretic device and associated methods
CA2622777A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoresis device to deliver multiple active agents to biological interfaces
WO2007037476A1 (ja) * 2005-09-30 2007-04-05 Tti Ellebeau, Inc. 睡眠導入剤と興奮剤の投与量および投与時期を制御するイオントフォレーシス装置
US20090299265A1 (en) * 2005-09-30 2009-12-03 Tti Ellebeau, Inc. Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same
US20070197955A1 (en) * 2005-10-12 2007-08-23 Transcutaneous Technologies Inc. Mucous membrane adhesion-type iontophoresis device
US8634907B2 (en) * 2005-10-24 2014-01-21 Aciont, Inc. Intraocular iontophoretic device and associated methods
WO2007064486A1 (en) * 2005-11-30 2007-06-07 3M Innovative Properties Company Microneedle arrays and methods of use thereof
JP4804904B2 (ja) * 2005-12-09 2011-11-02 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置包装品
WO2007079116A1 (en) * 2005-12-28 2007-07-12 Tti Ellebeau, Inc. Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
WO2007079190A2 (en) * 2005-12-29 2007-07-12 Tti Ellebeau, Inc. Device and method for enhancing immune response by electrical stimulation
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
JP2010502293A (ja) * 2006-09-05 2010-01-28 Ｔｔｉ・エルビュー株式会社 誘導型電源を用いる経皮薬物送達システム、装置及び方法
CA2666207A1 (en) * 2006-10-13 2008-04-17 Noble House Group Pty. Ltd. Means for sampling animal blood
US20100076367A1 (en) * 2006-11-24 2010-03-25 Koninklijke Philips Electronics N. V. Iontophoretic device
US8062783B2 (en) 2006-12-01 2011-11-22 Tti Ellebeau, Inc. Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices
WO2009073686A1 (en) * 2007-12-03 2009-06-11 Trans Dermal Patents Company, Llc Agent delivery system and uses of the same
US8180447B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method for reversible chemical modulation of neural activity
US20090149797A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for reversible chemical modulation of neural activity
US8160695B2 (en) * 2007-12-05 2012-04-17 The Invention Science Fund I, Llc System for chemical modulation of neural activity
US8180446B2 (en) * 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8165669B2 (en) * 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8170659B2 (en) * 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8165668B2 (en) * 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
EP2247527A4 (en) 2008-02-07 2014-10-29 Univ Queensland MANUFACTURE OF TRANSDERMAL STAMP
CN101274120B (zh) 2008-04-29 2013-03-13 圣太科医疗科技（上海）有限公司 生物与医用多路低电压微电场发生仪
AU2009250341A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
EP2319579A4 (en) 2008-07-18 2012-12-26 Suntek Medical Scient And Technologies Shanghai DEVICE FOR DELIVERING A MEDICAMENT TO A CELL TARGET IN THE LIVER USING AN ELECTRIC FIELD NETWORK OF LOW STRENGTH
US20100061976A1 (en) * 2008-07-24 2010-03-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
US20100022991A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System and device for maintaining physiological levels of steroid hormone in a subject
US20100022497A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing a cardiovascular disease or condition utilizing estrogen receptor modulators based on APOE allelic profile of a mammalian subject
US20100022494A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method, device, and kit for maintaining physiological levels of steroid hormone in a subject
TW201121604A (en) * 2009-06-09 2011-07-01 Tti Ellebeau Inc Long life high capacity electrode, device, and method of manufacture
US8894630B2 (en) 2009-11-13 2014-11-25 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
US8439896B2 (en) * 2009-11-13 2013-05-14 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
US8784368B2 (en) * 2009-11-13 2014-07-22 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
JP5851422B2 (ja) * 2010-12-28 2016-02-03 テルモ株式会社 経皮的薬物投与装置
US20130017259A1 (en) 2011-07-06 2013-01-17 The Parkinson's Institute Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
EP2734263B1 (en) * 2011-07-18 2017-10-04 EMPI, Inc. Electrode and method of manufacture thereof
KR101314091B1 (ko) * 2011-07-26 2013-10-04 연세대학교 산학협력단 치료 부위내 경피 유전자 전달을 위한 일렉트로 마이크로니들 집적체 및 이의 제조방법
WO2013053022A1 (en) * 2011-10-12 2013-04-18 The University Of Queensland Delivery device
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
WO2014132239A1 (en) 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Drug delivery device
WO2014132240A1 (en) 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Transdermal drug delivery device
CN104415454B (zh) * 2013-08-26 2017-11-03 精能医学股份有限公司 改变神经阈值的高频电磁场刺激器
GB2517707B (en) 2013-08-28 2020-09-02 Pci Biotech As A device for light-induced rupture of endocytic vesicles to effect the delivery of an antigen
TWI519781B (zh) * 2014-01-28 2016-02-01 微凸科技股份有限公司 經皮微針陣列貼布
TWI548395B (zh) 2014-01-28 2016-09-11 微凸科技股份有限公司 連續經皮微針監測系統
TWI543799B (zh) * 2014-01-28 2016-08-01 微凸科技股份有限公司 乳酸量測裝置及運動訓練調整的方法
CN104970805B (zh) * 2014-04-01 2017-09-29 微凸科技股份有限公司 经皮微针阵列贴布及其制造方法
CN104970804B (zh) * 2014-04-01 2018-05-04 微凸科技股份有限公司 连续经皮微针监测系统
CN103908240B (zh) * 2014-04-03 2016-08-17 深圳市太极医疗科技有限公司 一种人体电信号监测用电极片
RU2699278C2 (ru) * 2014-05-02 2019-09-04 Конинклейке Филипс Н.В. Устройство для инактивации бактерий
CN105455855B (zh) * 2014-09-04 2018-05-25 微凸科技股份有限公司 乳酸量测装置及运动训练调整的方法
JP2018511355A (ja) 2015-01-28 2018-04-26 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 薬剤送達方法及びシステム
AU2016214968B2 (en) 2015-02-02 2021-02-25 Vaxxas Pty Limited Microprojection array applicator and method
AU2016228779A1 (en) 2015-03-12 2017-09-07 Chrono Therapeutics Inc. Craving input and support system
FR3034017B1 (fr) * 2015-03-24 2018-11-02 Feeligreen Matrice polymerique adhesive pour iontophorese et dispositif pour l'iontophorese comprenant ladite matrice
JP6987642B2 (ja) * 2015-06-25 2022-01-05 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 治療学的物質の局所的送達を制御する電気穿孔法システム
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
EP3355981B1 (en) 2015-09-28 2025-11-19 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
PL3393575T3 (pl) * 2015-12-22 2024-06-17 Inovio Pharmaceuticals, Inc. Urządzenie do elektroporacji z pakietem baterii z przełącznikiem zasilania
ITUB20160311A1 (it) * 2016-01-18 2017-07-18 Rise Tech S R L Elettrodo flessibile per l'applicazione di un campo elettrico al corpo umano
WO2018106723A1 (en) * 2016-12-05 2018-06-14 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
IL267093B (en) 2016-12-14 2022-08-01 Medimmune Llc Embedded multiple-part sensor within a plunger rod to capture and transmit injection information
EP3558265B1 (en) * 2016-12-22 2025-04-16 Ohio State Innovation Foundation Interpenetrating microstructures for nanochannel-based cargo delivery
EP3565617A1 (en) 2017-01-06 2019-11-13 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
TWI629076B (zh) * 2017-01-12 2018-07-11 滙特生物科技股份有限公司 整合離子導入與微針之穿戴式注射裝置
EP3606760B1 (en) 2017-03-31 2023-09-27 Vaxxas Pty Limited Device and method for coating surfaces
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
JP7229483B2 (ja) * 2017-08-30 2023-02-28 国立大学法人東北大学 皮膚の疾患又は状態の検出、診断又は治療のための皮膚パッチデバイス及び皮膚パッチデバイスを備えたキット。
WO2019075380A1 (en) * 2017-10-12 2019-04-18 Northwestern University TARGETED ADMINISTRATION OF BIOLOGICAL THERAPEUTIC AGENTS
GB2568287A (en) * 2017-11-10 2019-05-15 Sisaf Ltd Apparatus and methods for the transdermal delivery of active agents
KR20210008328A (ko) 2018-03-07 2021-01-21 수부 랩스, 인크. 열 섬유의 자극을 통한 통증 완화 개선을 위한 시스템 및 방법
EP3801732A4 (en) 2018-05-29 2022-04-27 Morningside Venture Investments Limited METHODS AND SYSTEMS FOR DRUG DELIVERY
US12397141B2 (en) 2018-11-16 2025-08-26 Morningside Venture Investments Limited Thermally regulated transdermal drug delivery system
US12508423B2 (en) 2019-02-04 2025-12-30 Rutgers, The State University Of New Jersey Device for tissue electrotransfer using a microelectrode
WO2020233604A1 (zh) * 2019-05-20 2020-11-26 上海必修福企业管理有限公司 电场发生装置及其用途以及使待透皮物质进入目标对象的方法
CN113368384A (zh) * 2021-06-21 2021-09-10 温州医科大学慈溪生物医药研究院 脂质体电渗助导的大分子药物入脑的递送系统
JP7084666B1 (ja) 2021-10-12 2022-06-15 株式会社レーベン 生体電気刺激具
JP7776843B1 (ja) * 2025-08-20 2025-11-27 国立大学法人東北大学 流体送出デバイス

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
US4734090A (en) * 1986-07-18 1988-03-29 Drug Delivery Systems Inc. Electrical transdermal drug applicator
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
EP0398960B1 (en) * 1988-01-21 1995-12-06 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
US5147296A (en) * 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US4950229A (en) * 1989-09-25 1990-08-21 Becton, Dickinson And Company Apparatus for an electrode used for iontophoresis
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5047007A (en) * 1989-12-22 1991-09-10 Medtronic, Inc. Method and apparatus for pulsed iontophoretic drug delivery
US5464386A (en) * 1992-08-17 1995-11-07 Genetronics, Inc. Transdermal drug delivery by electroincorporation of vesicles
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
AU2947795A (en) * 1994-06-24 1996-01-19 Cygnus, Inc. Pulsatile delivery systems of biologically active agents using electro voltage pulsing for controlling membrane permeability
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
EP0914178B1 (en) * 1996-06-18 2003-03-12 Alza Corporation Device for enhancing transdermal agent delivery or sampling
DE69839969D1 (de) * 1997-12-11 2008-10-16 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
JP4061022B2 (ja) * 1997-12-11 2008-03-12 アルザ・コーポレーション 経皮輸送剤の流量促進装置
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6591133B1 (en) * 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices

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JP2007526794A (ja) 2007-09-20
KR20070011240A (ko) 2007-01-24
CN1905920A (zh) 2007-01-31
AR047039A1 (es) 2006-01-04
MXPA06005509A (es) 2007-05-23
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US20060036209A1 (en) 2006-02-16

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