BRPI0416272A - usos do receptor fprl1, e de compostos, uso profilático de compostos, métodos de triagem para um composto capaz de afetar uma ou mais atividades de um receptor fprl1, de tratamento ou prevenção de inflamação, de identificação de um composto de indução de vasodilatação, para antagonismo de uma resposta vasoconstrutiva a um sulfidopeptìdeo leucotrieno em um indivìduo, e para estimulação de proliferação celular em um indivìduo, e, composto - Google Patents

usos do receptor fprl1, e de compostos, uso profilático de compostos, métodos de triagem para um composto capaz de afetar uma ou mais atividades de um receptor fprl1, de tratamento ou prevenção de inflamação, de identificação de um composto de indução de vasodilatação, para antagonismo de uma resposta vasoconstrutiva a um sulfidopeptìdeo leucotrieno em um indivìduo, e para estimulação de proliferação celular em um indivìduo, e, composto

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Publication number
BRPI0416272A
BRPI0416272A BRPI0416272-2A BRPI0416272A BRPI0416272A BR PI0416272 A BRPI0416272 A BR PI0416272A BR PI0416272 A BRPI0416272 A BR PI0416272A BR PI0416272 A BRPI0416272 A BR PI0416272A
Authority
BR
Brazil
Prior art keywords
compounds
compound
individual
fprl1
fprl1 receptor
Prior art date
Application number
BRPI0416272-2A
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English (en)
Inventor
Norman Nash
Audra L Scully
Luis Gardell
Roger Olsson
Magnus Gustafsson
Original Assignee
Acadia Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acadia Pharm Inc filed Critical Acadia Pharm Inc
Publication of BRPI0416272A publication Critical patent/BRPI0416272A/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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Abstract

"USOS DO RECEPTOR FPRL1, E DE COMPOSTOS, USO PROFILáTICO DE COMPOSTOS MéTODOS DE TRIAGEM PARA UM COMPOSTO CAPAZ DE AFETAR UMA OU MAIS ATIVIDADES DE UM RECEPTOR FPRL1, DE TRATAMENTO OU PREVENçãO DE INFLAMAçãO, DE IDENTIFICAçãO DE UM COMPOSTO, DE INDUçãO DE VASODILATAçãO, PARA ANTAGONISMO DE UMA RESPOSTA VASOCONSTRITIVA A UM SULFIDOPEPTìDEO LEUCOTRIENO EM UM INDIVìDUO, E PARA ESTIMULAçãO DE PROLIFERAçãO CELULAR EM UM INDIVìDUO, E, COMPOSTO". São aqui descritos compostos que seletivamente ativam o receptor FPRL1. São adicionalmente descritos métodos de alívio das respostas inflamatórias pela regulação de etapas chave em tráfego de leucócitos e na prevenção de dano de tecido mediado por neutrófilo pela administração a um indivíduo de uma quantidade terapeuticamente efetiva de compostos aqui descritos. Além disso, são proporcionados métodos de modulação, ou especificamente de agonismo de receptor FPRL1 pela administração de uma quantidade terapeuticamente efetiva de compostos aqui descritos.
BRPI0416272-2A 2003-11-07 2004-11-04 usos do receptor fprl1, e de compostos, uso profilático de compostos, métodos de triagem para um composto capaz de afetar uma ou mais atividades de um receptor fprl1, de tratamento ou prevenção de inflamação, de identificação de um composto de indução de vasodilatação, para antagonismo de uma resposta vasoconstrutiva a um sulfidopeptìdeo leucotrieno em um indivìduo, e para estimulação de proliferação celular em um indivìduo, e, composto BRPI0416272A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51847603P 2003-11-07 2003-11-07
US51908503P 2003-11-10 2003-11-10
US59292604P 2004-07-30 2004-07-30
PCT/US2004/036952 WO2005047899A2 (en) 2003-11-07 2004-11-04 Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation

Publications (1)

Publication Number Publication Date
BRPI0416272A true BRPI0416272A (pt) 2007-01-09

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BRPI0416272-2A BRPI0416272A (pt) 2003-11-07 2004-11-04 usos do receptor fprl1, e de compostos, uso profilático de compostos, métodos de triagem para um composto capaz de afetar uma ou mais atividades de um receptor fprl1, de tratamento ou prevenção de inflamação, de identificação de um composto de indução de vasodilatação, para antagonismo de uma resposta vasoconstrutiva a um sulfidopeptìdeo leucotrieno em um indivìduo, e para estimulação de proliferação celular em um indivìduo, e, composto

Country Status (7)

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EP (1) EP1692502A2 (pt)
JP (1) JP2007516434A (pt)
KR (1) KR20060130064A (pt)
AU (1) AU2004290368A1 (pt)
BR (1) BRPI0416272A (pt)
CA (1) CA2544983A1 (pt)
WO (1) WO2005047899A2 (pt)

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AU2002332929A1 (en) 2001-09-07 2003-03-24 Bristol-Myers Squibb Company Polynucleotide encoding a novel human g-protein coupled receptor, hgprbmy39
US20100291089A1 (en) * 2005-07-07 2010-11-18 Postech Academy-Industry Foundation Ligand of regulating immune response, and use thereof in treating an immune response-related disease
AR069650A1 (es) * 2007-12-14 2010-02-10 Actelion Pharmaceuticals Ltd Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
RU2492167C2 (ru) * 2007-12-18 2013-09-10 Актелион Фармасьютиклз Лтд Производные аминотриазола в качестве агонистов alх
AU2010250789B2 (en) * 2009-05-18 2015-05-14 Actelion Pharmaceuticals Ltd Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists
RU2544862C2 (ru) 2009-06-09 2015-03-20 Актелион Фармасьютиклз Лтд Фторированные аминотриазольные производные
CA2760887A1 (en) 2009-06-12 2010-12-16 Actelion Pharmaceuticals Ltd Oxazole and thiazole derivatives as alx receptor agonists
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