BRPI0416437A - mutantes da bactéria do rúmen e processo para preparar ácido succìnio utilizando as mesmas - Google Patents

mutantes da bactéria do rúmen e processo para preparar ácido succìnio utilizando as mesmas

Info

Publication number
BRPI0416437A
BRPI0416437A BRPI0416437-7A BRPI0416437A BRPI0416437A BR PI0416437 A BRPI0416437 A BR PI0416437A BR PI0416437 A BRPI0416437 A BR PI0416437A BR PI0416437 A BRPI0416437 A BR PI0416437A
Authority
BR
Brazil
Prior art keywords
succinic acid
gene
mutants
producing
bacterial
Prior art date
Application number
BRPI0416437-7A
Other languages
English (en)
Inventor
Lee
Sang Yup
Jun Sang
Original Assignee
Korea Advanced Inst Sci & Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36609129&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0416437(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from KR1020030084934A external-priority patent/KR100556099B1/ko
Priority claimed from KR1020040028105A external-priority patent/KR100630819B1/ko
Application filed by Korea Advanced Inst Sci & Tech filed Critical Korea Advanced Inst Sci & Tech
Publication of BRPI0416437A publication Critical patent/BRPI0416437A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"MUTANTES DA BACTéRIA DO RúMEN E PROCESSO PARA PREPARAR áCIDO SUCCìNICO UTILIZANDO AS MESMAS". A presente invenção refere-se a novos mutantes da bactéria do rúmen resultantes da disrupção de um gene de lactato deshidrogenasa (ldha) e um gene de piruvato formato-liase (pfl) (envolvidos na produção de ácido láctico, ácido fórmico e ácido acético) a partir de bactéria do rúmen; um novo mutante bacterial (Mannheimia sp. LPK7) com disrupções de um gene de lactato deshidrogenasa (ldhA), um gene de piruvato formato-liase (plf), um gene de fosfotransacetilase (pta ), e um gene de acetato quinase (ackA); um novo mutante bacterial (Mannheimia sp. LPK4) com disrupções de um lactato deshidrogenasa (ldhA), um gene de piruvato formato-liase gene (pfl) e um gene de fosfoenolpiruvato carboxilase (ppc) envolvido na imobilização de CO~ 2~ em um caminho metabólico da produção de ácido succínico; e um método para a produção de ácido succínico, caracterizado pela cultura dos acima mencionados mutantes em condições anaeróbicas. os mutantes bacteriais objeto da invenção têm a propriedade de produzir ácido succínico a uma concentração elevada enquanto produz em poucos ou nenhum outro ácido orgânico, em comparação com as cepas selvagens anteriores para a produção de vários ácidos orgânicos. Assim, os mutantes bacteriais objeto da invenção são úteis como cepas para a produção industrial de ácido succínico.
BRPI0416437-7A 2003-11-27 2004-05-20 mutantes da bactéria do rúmen e processo para preparar ácido succìnio utilizando as mesmas BRPI0416437A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020030084934A KR100556099B1 (ko) 2003-11-27 2003-11-27 루멘 박테리아 변이균주 및 이를 이용한 숙신산의 제조방법
KR1020040028105A KR100630819B1 (ko) 2004-04-23 2004-04-23 신규 루멘 박테리아 변이균주 및 이를 이용한 숙신산의제조방법
PCT/KR2004/001210 WO2005052135A1 (en) 2003-11-27 2004-05-20 Novel rumen bacteria variants and process for preparing succinic acid employing the same

Publications (1)

Publication Number Publication Date
BRPI0416437A true BRPI0416437A (pt) 2007-02-21

Family

ID=36609129

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416437-7A BRPI0416437A (pt) 2003-11-27 2004-05-20 mutantes da bactéria do rúmen e processo para preparar ácido succìnio utilizando as mesmas

Country Status (12)

Country Link
US (1) US7470530B2 (pt)
EP (1) EP1692271B2 (pt)
JP (2) JP4672671B2 (pt)
AT (1) ATE439427T1 (pt)
AU (1) AU2004292642B2 (pt)
BR (1) BRPI0416437A (pt)
CA (1) CA2545363C (pt)
DE (1) DE602004022584D1 (pt)
DK (1) DK1692271T4 (pt)
NZ (1) NZ547305A (pt)
RU (1) RU2376369C2 (pt)
WO (1) WO2005052135A1 (pt)

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Also Published As

Publication number Publication date
US7470530B2 (en) 2008-12-30
JP2010263911A (ja) 2010-11-25
DE602004022584D1 (de) 2009-09-24
US20070054387A1 (en) 2007-03-08
ATE439427T1 (de) 2009-08-15
EP1692271A1 (en) 2006-08-23
NZ547305A (en) 2009-05-31
RU2376369C2 (ru) 2009-12-20
CA2545363C (en) 2011-11-15
AU2004292642B2 (en) 2008-02-07
DK1692271T3 (da) 2009-10-19
WO2005052135A1 (en) 2005-06-09
AU2004292642A1 (en) 2005-06-09
JP4672671B2 (ja) 2011-04-20
DK1692271T4 (da) 2022-09-26
CA2545363A1 (en) 2005-06-09
EP1692271B2 (en) 2022-08-03
JP2007512015A (ja) 2007-05-17
RU2006122804A (ru) 2008-01-10
EP1692271A4 (en) 2007-08-08
EP1692271B1 (en) 2009-08-12

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