BRPI0416590A - excipientes em veìculos de distribuição de fármacos - Google Patents

excipientes em veìculos de distribuição de fármacos

Info

Publication number
BRPI0416590A
BRPI0416590A BRPI0416590-0A BRPI0416590A BRPI0416590A BR PI0416590 A BRPI0416590 A BR PI0416590A BR PI0416590 A BRPI0416590 A BR PI0416590A BR PI0416590 A BRPI0416590 A BR PI0416590A
Authority
BR
Brazil
Prior art keywords
polymers
excipients
drug delivery
delivery vehicles
gel compositions
Prior art date
Application number
BRPI0416590-0A
Other languages
English (en)
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0416590A publication Critical patent/BRPI0416590A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/27Growth hormone [GH], i.e. somatotropin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"EXCIPIENTES EM VEìCULOS DE DISTRIBUIçãO DE FáRMACOS". A presente invenção fornece composições de gel injetáveis para depósito e kits que fornecem um excipiente para modular uma taxa de liberação e estabilizar os agente benéficos. São fornecidos também métodos para administrar e preparar tais sistemas. As composições do gel compreendem polímeros biodegradáveis, bioerodíveis, e solventes imiscíveis em água, em quantidades eficazes para plastificar os polímeros e formar géis com os polímeros. Os excipientes apropriados incluem modificadores de pH, agentes redutores e antioxidantes.
BRPI0416590-0A 2003-11-14 2004-11-12 excipientes em veìculos de distribuição de fármacos BRPI0416590A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51993603P 2003-11-14 2003-11-14
US10/985,122 US20050106214A1 (en) 2003-11-14 2004-11-10 Excipients in drug delivery vehicles
PCT/US2004/037781 WO2005049069A1 (en) 2003-11-14 2004-11-12 Excipients in drug delivery vehicles

Publications (1)

Publication Number Publication Date
BRPI0416590A true BRPI0416590A (pt) 2007-01-30

Family

ID=34576891

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416590-0A BRPI0416590A (pt) 2003-11-14 2004-11-12 excipientes em veìculos de distribuição de fármacos

Country Status (12)

Country Link
US (2) US20050106214A1 (pt)
EP (1) EP1691826A4 (pt)
JP (1) JP4916887B2 (pt)
KR (1) KR20060125749A (pt)
AU (2) AU2004291093A1 (pt)
BR (1) BRPI0416590A (pt)
CA (1) CA2545923A1 (pt)
IL (1) IL175602A0 (pt)
MX (1) MXPA06005463A (pt)
NO (1) NO20062780L (pt)
TW (1) TW200529842A (pt)
WO (1) WO2005049069A1 (pt)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040058101A (ko) * 2001-11-14 2004-07-03 알자 코포레이션 카테터 주입가능한 데포 조성물 및 그의 용도
ATE418323T1 (de) * 2002-11-06 2009-01-15 Alza Corp Depot-formulierungen mit verzögerter freisetzung
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US20060252830A1 (en) * 2005-05-06 2006-11-09 Brandon Stephen F Method for the treatment of magnesium and potassium deficiencies
US20060252831A1 (en) * 2005-05-06 2006-11-09 Christopher Offen Method for the treatment of magnesium and potassium deficiencies
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
EP1912627B1 (en) * 2005-08-11 2016-08-10 Promedon S.A. Composition comprising polymeric, water-insoluble, anionic particles, processes and uses
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US7261742B2 (en) 2005-10-13 2007-08-28 S.C. Johnson & Son, Inc. Method of deodorizing a textile
US7407922B2 (en) * 2005-10-13 2008-08-05 S.C. Johnson & Son, Inc. Deodorizing compositions
MX2008014870A (es) 2006-05-30 2009-02-12 Intarcia Therapeutics Inc Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas.
EP1872807A1 (en) * 2006-06-30 2008-01-02 Scil Technology GmbH Biomaterial containing degradation stabilized polymer
EP2049081B1 (en) 2006-08-09 2012-11-14 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
CA2664341C (en) 2006-10-05 2018-11-06 Ikaria, Inc. Liquid chalcogenide compositions and methods of manufacturing and using the same
EP2236546B1 (en) * 2006-10-31 2011-12-28 Surmodics Pharmaceuticals, Inc. Speronized polymer particles
HRP20130259T1 (hr) 2007-04-23 2013-04-30 Intarcia Therapeutics, Inc. Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe
EP2152315B1 (en) 2007-05-25 2016-01-06 Indivior UK Limited Sustained delivery formulations of risperidone compounds
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
SMT201700583T1 (it) 2009-09-28 2018-01-11 Intarcia Therapeutics Inc Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario
CN102233129B (zh) * 2010-04-29 2014-07-09 上海交通大学 一种预防或治疗视网膜损伤的长效缓释制剂及其制备方法
EP2590628A1 (en) * 2010-06-30 2013-05-15 Evonik Corporation Implant processing methods for thermally labile and other bioactive agents and implants prepared from same
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
KR101494594B1 (ko) 2011-08-30 2015-02-23 주식회사 종근당 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
HK1211232A1 (en) 2012-12-21 2016-05-20 Sanofi Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists
KR101586790B1 (ko) 2012-12-28 2016-01-19 주식회사 종근당 음이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
HK1220628A1 (zh) 2013-03-11 2017-05-12 Durect Corporation 包含高粘度液体载体的可注射控制释放组合物
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
EP3080152A1 (en) 2013-12-13 2016-10-19 Sanofi Non-acylated exendin-4 peptide analogues
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重glp-1/gip受體促效劑
MX386702B (es) 2014-02-10 2025-03-19 Fred Hutchinson Cancer Center Tratamiento con halogeno de ataque cardiaco y lesion isquemica.
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自exendin-4之雙重glp-1/升糖素受體促效劑
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
KR101686986B1 (ko) 2014-07-28 2016-12-16 에스케이케미칼주식회사 류프로라이드를 포함하는 속효성과 지속성을 동시에 갖는 약제학적 조성물
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
NZ731309A (en) 2014-11-07 2022-02-25 Indivior Uk Ltd Buprenorphine dosing regimens
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
JP7145363B2 (ja) * 2015-11-23 2022-10-03 グレイス セラピューティクス インコーポレイテッド 局所皮膜形成スプレー
EP3452031A4 (en) * 2016-05-05 2019-12-11 Liquidia Technologies, Inc. PRECISION-CONTROLLED LOADING AND RELEASE PARTICLES FOR POST-OPERATIONAL PAIN
RU2760007C2 (ru) 2016-05-16 2021-11-22 Интарсия Терапьютикс, Инк. Полипептиды, селективные к рецепторам глюкагона, и способы их применения
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
WO2018017696A1 (en) 2016-07-19 2018-01-25 Ecolab Usa Inc. Methods and cleaning solutions for removing chewing gum and other sticky food substances
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
JP2023515918A (ja) 2020-01-13 2023-04-17 デュレクト コーポレーション 不純物が低減された徐放性薬物送達システム及び関連の方法
CN111388744B (zh) * 2020-01-15 2021-05-18 华中科技大学 一种凝胶贮库及其制法与制备术后止血制剂的应用
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods
CN118201599A (zh) * 2021-12-24 2024-06-14 四川科伦药物研究院有限公司 一种可平稳释放的持续性递送制剂及其制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443340A (en) * 1981-10-09 1984-04-17 Betz Laboratories, Inc. Control of iron induced fouling in water systems
US4985404A (en) * 1984-10-04 1991-01-15 Monsanto Company Prolonged release of biologically active polypeptides
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
KR970007322B1 (ko) * 1991-12-19 1997-05-07 미쓰이도오아쓰 가가쿠 가부시키가이샤 폴리히드록시 카르복실산 및 그 제조방법
US5192743A (en) * 1992-01-16 1993-03-09 Genentech, Inc. Reconstitutable lyophilized protein formulation
US5656297A (en) * 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
AU668384B2 (en) * 1992-03-12 1996-05-02 Alkermes Controlled Therapeutics, Inc. Controlled release ACTH containing microspheres
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US5242910A (en) * 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
WO1994012158A1 (en) * 1992-12-02 1994-06-09 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
ATE203157T1 (de) * 1996-12-20 2001-08-15 Alza Corp Injizierbare depotgelzubereitung und herstellungsverfahren
RU2184564C2 (ru) * 2000-01-28 2002-07-10 Общество С Ограниченной Ответственностью "Ферон" Лекарственный гель
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
US6495534B2 (en) * 2000-05-15 2002-12-17 Pharmacia & Upjohn Spa Stabilized aqueous suspensions for parenteral use
WO2002032398A2 (en) * 2000-10-16 2002-04-25 Massachusetts Institute Of Technology Lipid-protein-sugar particles for drug delivery
DK1372729T3 (da) * 2001-02-23 2009-06-22 Genentech Inc Nedbrydelige polymere til injektion
WO2002089849A1 (en) * 2001-05-07 2002-11-14 Corium International Compositions and delivery systems for administration of a local anesthetic agent
KR20040058101A (ko) * 2001-11-14 2004-07-03 알자 코포레이션 카테터 주입가능한 데포 조성물 및 그의 용도
EP1446100B1 (en) * 2001-11-14 2011-05-04 Durect Corporation Injectable depot compositions and uses thereof
US20060083778A1 (en) * 2002-05-03 2006-04-20 Dean Allison Controlled release compositions of estradiol metabolites
TWI353854B (en) * 2002-06-25 2011-12-11 Alza Corp Short duration depot formulations
ATE418323T1 (de) * 2002-11-06 2009-01-15 Alza Corp Depot-formulierungen mit verzögerter freisetzung
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles

Also Published As

Publication number Publication date
TW200529842A (en) 2005-09-16
IL175602A0 (en) 2006-09-05
EP1691826A1 (en) 2006-08-23
NO20062780L (no) 2006-08-14
WO2005049069A1 (en) 2005-06-02
AU2004291093A1 (en) 2005-06-02
US20120177697A1 (en) 2012-07-12
JP4916887B2 (ja) 2012-04-18
US20050106214A1 (en) 2005-05-19
AU2011201826A1 (en) 2011-05-19
EP1691826A4 (en) 2012-08-22
JP2007511524A (ja) 2007-05-10
AU2011201826B2 (en) 2013-06-13
CA2545923A1 (en) 2005-06-02
MXPA06005463A (es) 2006-08-11
KR20060125749A (ko) 2006-12-06

Similar Documents

Publication Publication Date Title
BRPI0416590A (pt) excipientes em veìculos de distribuição de fármacos
BRPI0416032A (pt) excipientes em veìculos de distribuição de fármacos
PT1061900E (pt) Composicoes e metodos para libertacao de uma droga
BR0315304A (pt) Formulações com depósito para liberação controlada
BR0313539A (pt) Composições depósito de polìmero multimodais injetáveis e seus usos
CR9351A (es) Composiciones y metodos para aplicaicon topica y suministro transdermico de toxina botulinica
BR0212475A (pt) Composições farmacêuticas
MX2009003737A (es) Composicion inyectable en deposito y su procedimiento de preparacion.
BRPI0414907A (pt) formulações farmacêuticas com liberação sustentada injetáveis, orais ou tópicas
BRPI0113286B8 (pt) pirazóis substituídos e composição farmacêutica compreendendo os mesmos.
ATE392886T1 (de) Injizierbare depotzusammensetzungen und deren verwendung
DK0839026T3 (da) Micellære polyether-blokcopolymerkompositioner til målretning af biologiske midler
MA25681A1 (fr) Systeme d'administration de compositions orales de soins comprenant une resine d'organosiloxane utilisant une bandelette de soutien amovible.
AR044926A1 (es) Sistema de suministro de farmacos gelificante in situ
MX2009002653A (es) Derivados de acido hialuronico obtenidos via reticulacion de "quimica modular".
BR9915235A (pt) ácidos hialurÈnicos reticulados e usos médicos dos mesmos
IL154888A (en) Aqueous Pharmaceutical Gel Preparation Containing At least One Vitamin D or One Vitamin D Analog At least One Corticosteroid
MXPA05014193A (es) Fomas de dosis de liberacion sostenida de anestesicos para el manejo del dolor.
PA8479201A1 (es) Derivados del acido hidroxi-pipecolato hidroxamico
BR0316310A (pt) Composições farmacêuticas tendo um veìculo modificado
BR0313428A (pt) Composições farmacêuticas de drogas semi-ordenados e polìmeros
BR0308486A (pt) Composição tópica compreendendo um ciclofrutano, um veìculo e uma droga
SI1608346T1 (sl) Spojine za sproščanje zdravilnih učinkovin na osnovi alfa-hidroksi kislinskih estrov in postopki njihove uporabe
ES2195184T3 (es) Preparaciones cosmeticas.
BR0009472A (pt) Antagonistas de lhrh com propriedades desolubilidade aperfeiçoadas

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.