BRPI0417828A - cicloexadepsipeptìdeos de 18 membros, substituìdos com nitrobenzila e aminobenzila, para controle de endoparasitas e processo para preparação dos mesmos - Google Patents

cicloexadepsipeptìdeos de 18 membros, substituìdos com nitrobenzila e aminobenzila, para controle de endoparasitas e processo para preparação dos mesmos

Info

Publication number
BRPI0417828A
BRPI0417828A BRPI0417828-9A BRPI0417828A BRPI0417828A BR PI0417828 A BRPI0417828 A BR PI0417828A BR PI0417828 A BRPI0417828 A BR PI0417828A BR PI0417828 A BRPI0417828 A BR PI0417828A
Authority
BR
Brazil
Prior art keywords
alkyl
cyclohexadepsipeptides
membered
optionally substituted
nitrobenzyl
Prior art date
Application number
BRPI0417828-9A
Other languages
English (en)
Inventor
Peter Jeschke
Achim Harder
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of BRPI0417828A publication Critical patent/BRPI0417828A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"CICLOEXADEPSIPEPTìDEOS DE 18 MEMBROS, SUBSTITUìDOS COM NITROBENZILA E AMINOBENZILA, PARA CONTROLE DE ENDOPARASITAS E UM PROCESSO PARA PREPARAçãO DOS MESMOS". A presente invenção refere-se a depsipeptídeos cíclicos, particularmente, cicloexadepsipeptídeos de 18 membros, da fórmula geral (I) e sais dos mesmos, na qual R¬ 1¬ representa nitrobenzila ou R<39>R<39><39>N-benzila, no qual R<39> e R<39><39>, independentemente um do outro, significam, respectivamente, hidrogênio, C~ 1~-C~ 4~-alquila, formila, C~ 1~-C~ 4~-alcóxi-C~ 1~-C~ 4~-alquila, C~ 1~C~ 4~-alcóxi-carbonila, hidróxi-C~ 1~-C~ 2~-alquil-sulfoníl-C~ 1~-C~ 2~-alquila, opcionalmente substituída, ou R<39> e R<39><39>, junto com o átomo de nitrogênio ao qual estão ligados, formam um heterocicio mono- ou policíclico, saturado ou insaturado, opcionalmente substituído, e/ou espirocíclico, opcionalmente conjugado, que contém um a três outros heteroátomos da série nitrogênio, oxigênio e enxofre, ou R<39> e R<39><39> formam, em conjunto, C~ 3~-C~ 5~-alquileno-monocarbonila ou um radical diacila de um ácido C~ 4~-C~ 6~-dicarboxílico, opcionalmente substituído, e R¬ 2¬, R¬ 3¬ e R¬ 4¬, independentemente um do outro, representam C~ 1~-C~ 4~-alquila. A invenção também se refere aos isómeros ópticos e racematos dos referidos depsipeptídeos, a um processo para produção dos mesmos e uso dos mesmos para controle de endoparasitas.
BRPI0417828-9A 2003-12-19 2004-12-07 cicloexadepsipeptìdeos de 18 membros, substituìdos com nitrobenzila e aminobenzila, para controle de endoparasitas e processo para preparação dos mesmos BRPI0417828A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10359798A DE10359798A1 (de) 2003-12-19 2003-12-19 Cyclohexadepsipeptide zur Bekämpfung von Endoparasiten und ein Verfahren zu ihrer Herstellung
PCT/EP2004/013896 WO2005063277A1 (de) 2003-12-19 2004-12-07 18 gliedrige nitrobenzyl-und aminobenzyl-substituierte cyclohexadepsipeptide zur bekämpfung von endoparasiten und ein verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
BRPI0417828A true BRPI0417828A (pt) 2007-04-10

Family

ID=34683580

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417828-9A BRPI0417828A (pt) 2003-12-19 2004-12-07 cicloexadepsipeptìdeos de 18 membros, substituìdos com nitrobenzila e aminobenzila, para controle de endoparasitas e processo para preparação dos mesmos

Country Status (13)

Country Link
US (1) US7645738B2 (pt)
EP (1) EP1715883B1 (pt)
JP (1) JP5196788B2 (pt)
AT (1) ATE429239T1 (pt)
AU (1) AU2004308593B2 (pt)
BR (1) BRPI0417828A (pt)
CA (1) CA2550344A1 (pt)
DE (2) DE10359798A1 (pt)
ES (1) ES2323531T3 (pt)
MX (1) MXPA06006662A (pt)
NZ (1) NZ547999A (pt)
WO (1) WO2005063277A1 (pt)
ZA (1) ZA200604945B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009012423A1 (de) * 2009-03-10 2010-09-16 Bayer Animal Health Gmbh Zubereitung auf Ölbasis
WO2012028556A1 (en) * 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4400464A1 (de) * 1994-01-11 1995-07-13 Bayer Ag Endoparasitizide Mittel
DE4401389A1 (de) * 1994-01-19 1995-07-20 Bayer Ag Verwendung von cyclischen Depsipeptiden mit 12 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 12 Ringatomen und Verfahren zu ihrer Herstellung
DE4406025A1 (de) * 1994-02-24 1995-08-31 Bayer Ag Milchsäure-haltige cyclische Depsipeptide mit 18 Ringatomen als endoparasitizide Mittel und Verfahren zu ihrer Herstellung
DE4412492A1 (de) * 1994-04-12 1995-10-19 Bayer Ag Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen
DE19520275A1 (de) * 1995-06-02 1996-12-05 Bayer Ag Endoparasitizide Mittel
BR9810412A (pt) * 1997-06-04 2000-08-22 Bayer Ag Desoxiciclodepsipeptìdios e seu emprego para o combate de endoparasitas

Also Published As

Publication number Publication date
JP5196788B2 (ja) 2013-05-15
EP1715883A1 (de) 2006-11-02
ES2323531T3 (es) 2009-07-20
US7645738B2 (en) 2010-01-12
EP1715883B1 (de) 2009-04-22
US20080026990A1 (en) 2008-01-31
MXPA06006662A (es) 2006-08-31
NZ547999A (en) 2010-07-30
ATE429239T1 (de) 2009-05-15
DE10359798A1 (de) 2005-07-21
CA2550344A1 (en) 2005-07-14
WO2005063277A1 (de) 2005-07-14
AU2004308593A1 (en) 2005-07-14
DE502004009401D1 (de) 2009-06-04
ZA200604945B (en) 2007-09-26
AU2004308593B2 (en) 2011-11-10
JP2007514671A (ja) 2007-06-07

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: BAYER ANIMAL HEALTH GMBH (DE)

Free format text: TRANSFERIDO DE: BAYER HEALTHCARE AG

B25A Requested transfer of rights approved

Owner name: BAYER INTELLECTUAL PROPERTY GMBH (DE)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]