BRPI0417943A - antagonistas de receptor de crf e métodos relacionados para essa finalidade - Google Patents
antagonistas de receptor de crf e métodos relacionados para essa finalidadeInfo
- Publication number
- BRPI0417943A BRPI0417943A BRPI0417943-9A BRPI0417943A BRPI0417943A BR PI0417943 A BRPI0417943 A BR PI0417943A BR PI0417943 A BRPI0417943 A BR PI0417943A BR PI0417943 A BRPI0417943 A BR PI0417943A
- Authority
- BR
- Brazil
- Prior art keywords
- receptor antagonists
- crf receptor
- related methods
- crf
- disorders
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title abstract 4
- 229940044551 receptor antagonist Drugs 0.000 title abstract 4
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000002769 corticotropin releasing factor antagonist Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53203103P | 2003-12-22 | 2003-12-22 | |
| PCT/IB2004/004234 WO2005063755A1 (en) | 2003-12-22 | 2004-12-20 | Crf receptor antagonists and methods relating thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0417943A true BRPI0417943A (pt) | 2007-04-17 |
Family
ID=34738733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0417943-9A BRPI0417943A (pt) | 2003-12-22 | 2004-12-20 | antagonistas de receptor de crf e métodos relacionados para essa finalidade |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7737154B2 (no) |
| EP (1) | EP1697374B1 (no) |
| JP (1) | JP4926720B2 (no) |
| KR (1) | KR20070009537A (no) |
| CN (1) | CN1938309B (no) |
| AR (1) | AR046967A1 (no) |
| AU (1) | AU2004309168B2 (no) |
| BR (1) | BRPI0417943A (no) |
| CA (1) | CA2550948A1 (no) |
| IL (1) | IL176350A0 (no) |
| IS (1) | IS8526A (no) |
| MA (1) | MA29984B1 (no) |
| MY (1) | MY143499A (no) |
| NO (1) | NO20063230L (no) |
| NZ (1) | NZ547990A (no) |
| RU (1) | RU2394035C2 (no) |
| TW (1) | TW200530242A (no) |
| WO (1) | WO2005063755A1 (no) |
| ZA (1) | ZA200604574B (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| GB0519957D0 (en) * | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
| ATE430746T1 (de) * | 2004-10-19 | 2009-05-15 | Smithkline Beecham Cork Ltd | Crf-rezeptor-antagonisten und zugehörige verfahren |
| US8088779B2 (en) * | 2005-09-30 | 2012-01-03 | Smithkline Beecham (Cork) Limited | Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists |
| CA2662000C (en) * | 2006-09-20 | 2013-01-08 | Eli Lilly And Company | Thiophene pyrazolopyrimidine compounds |
| UA96458C2 (ru) | 2006-09-20 | 2011-11-10 | Эли Лилли Энд Компани | Тиазолпиразолопиримидиновые соединения как антагонисты рецептора crf1 |
| KR100854679B1 (ko) * | 2007-02-03 | 2008-08-27 | 김기형 | 심플 서비스 로케이션 프로토콜 네트워크 시스템 및 이를구성하는 에이전트. |
| EP2282998B1 (en) * | 2008-04-21 | 2014-09-10 | Albemarle Corporation | Processes for producing n-alkylpyrazole |
| ES2527849T3 (es) * | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
| WO2014060381A1 (de) | 2012-10-18 | 2014-04-24 | Bayer Cropscience Ag | Heterocyclische verbindungen als schädlingsbekämpfungsmittel |
| CN104884449A (zh) | 2012-10-31 | 2015-09-02 | 拜尔农作物科学股份公司 | 作为害虫防治剂的新的杂环化合物 |
| PT3130592T (pt) * | 2014-04-10 | 2019-11-21 | Hubei Bio Pharmaceutical Industrial Tech Institute Inc | Análogos do composto 4h-pirazolo[1,5-]benzimidazole como inibidores de parp |
| KR20250022913A (ko) | 2017-08-14 | 2025-02-17 | 스프루스 바이오사이언시스 인코포레이티드 | 코티코트로핀 방출 인자 수용체 길항제 |
| CN112423747A (zh) | 2018-04-27 | 2021-02-26 | 云杉生物科学公司 | 用于治疗睾丸肾上腺残余瘤和卵巢肾上腺残余瘤的方法 |
| CA3187362A1 (en) | 2020-07-27 | 2022-02-03 | John Thomas Feutrill | Compounds |
| MX2023001688A (es) | 2020-08-12 | 2023-02-22 | Spruce Biosciences Inc | Metodos y composiciones para tratar el sindrome de ovario poliquistico. |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997029109A1 (en) * | 1996-02-07 | 1997-08-14 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidines as crf receptor antagonists |
| US6313124B1 (en) * | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| HU229024B1 (en) | 1996-07-24 | 2013-07-29 | Bristol Myers Squibb Pharma Co | Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof |
| US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
| TR199900389T2 (xx) | 1996-08-28 | 2000-06-21 | Pfizer Inc. | �kame edilmi� 6,5-hetero-bisiklik t�revleri. |
| JP2002501532A (ja) * | 1997-05-30 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | 新規血管形成阻害薬 |
| PL200939B1 (pl) * | 1998-01-28 | 2009-02-27 | Bristol Myers Squibb Pharma Co | Związki [1,5-a]-pirazolo-1,3,5-triazynowe, środek farmaceutyczny i zastosowanie tych związków |
| AU4203500A (en) | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolopyrimidines as crf antagonists |
| YU23602A (sh) * | 1999-09-30 | 2004-09-03 | Neurogen Corporation | Amino supstituisani pirazolo /1,5/a/-1,5-pirimidini i pirazolo /1,5-a/-1,3,5-triazini |
| CO5271670A1 (es) * | 1999-10-29 | 2003-04-30 | Pfizer Prod Inc | Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas |
| WO2002088095A1 (en) * | 2001-04-30 | 2002-11-07 | Glaxo Group Limited | Fused pyrimidines as antagonists of the corticotropin releasing factor (crf) |
| WO2002100863A1 (en) * | 2001-06-12 | 2002-12-19 | Glaxo Group Limited | Corticotropin releasing factor antagonists |
| GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| ATE359782T1 (de) * | 2003-01-16 | 2007-05-15 | Sb Pharmco Inc | Heteroaryl-substituierte pyrrol(2, 3- b)pyridin- derivate als crf-rezeptor-antagonisten |
| US20070179161A1 (en) | 2003-03-31 | 2007-08-02 | Vernalis (Cambridge) Limited. | Pyrazolopyrimidine compounds and their use in medicine |
| US20070021429A1 (en) * | 2003-04-09 | 2007-01-25 | Yves St-Denis | Condensed n-heterocyclic compounds and their use as crf receptor antagonists |
| GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| EP1697369A1 (en) * | 2003-12-22 | 2006-09-06 | SB Pharmco Puerto Rico Inc | Crf receptor antagonists and methods relating thereto |
| DE102004008807A1 (de) * | 2004-02-20 | 2005-09-08 | Bayer Cropscience Ag | Pyrazolopyrimidine |
| ATE430746T1 (de) * | 2004-10-19 | 2009-05-15 | Smithkline Beecham Cork Ltd | Crf-rezeptor-antagonisten und zugehörige verfahren |
| GB0519957D0 (en) * | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
| US8088779B2 (en) * | 2005-09-30 | 2012-01-03 | Smithkline Beecham (Cork) Limited | Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists |
-
2004
- 2004-12-20 NZ NZ547990A patent/NZ547990A/en unknown
- 2004-12-20 AR ARP040104790A patent/AR046967A1/es not_active Application Discontinuation
- 2004-12-20 CN CN2004800420125A patent/CN1938309B/zh not_active Expired - Fee Related
- 2004-12-20 BR BRPI0417943-9A patent/BRPI0417943A/pt not_active Application Discontinuation
- 2004-12-20 US US10/596,648 patent/US7737154B2/en active Active
- 2004-12-20 AU AU2004309168A patent/AU2004309168B2/en not_active Ceased
- 2004-12-20 JP JP2006546391A patent/JP4926720B2/ja not_active Expired - Fee Related
- 2004-12-20 EP EP04820857A patent/EP1697374B1/en not_active Expired - Lifetime
- 2004-12-20 KR KR1020067012368A patent/KR20070009537A/ko not_active Ceased
- 2004-12-20 TW TW093139578A patent/TW200530242A/zh unknown
- 2004-12-20 MY MYPI20045253A patent/MY143499A/en unknown
- 2004-12-20 CA CA002550948A patent/CA2550948A1/en not_active Abandoned
- 2004-12-20 WO PCT/IB2004/004234 patent/WO2005063755A1/en not_active Ceased
- 2004-12-20 RU RU2006126675/04A patent/RU2394035C2/ru not_active IP Right Cessation
-
2006
- 2006-06-05 ZA ZA200604574A patent/ZA200604574B/en unknown
- 2006-06-15 IL IL176350A patent/IL176350A0/en unknown
- 2006-06-27 MA MA29147A patent/MA29984B1/fr unknown
- 2006-07-11 IS IS8526A patent/IS8526A/is unknown
- 2006-07-11 NO NO20063230A patent/NO20063230L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004309168A1 (en) | 2005-07-14 |
| NZ547990A (en) | 2010-04-30 |
| AR046967A1 (es) | 2006-01-04 |
| CA2550948A1 (en) | 2005-07-14 |
| RU2394035C2 (ru) | 2010-07-10 |
| RU2006126675A (ru) | 2008-01-27 |
| MA29984B1 (fr) | 2008-12-01 |
| IL176350A0 (en) | 2006-10-05 |
| EP1697374B1 (en) | 2012-08-29 |
| TW200530242A (en) | 2005-09-16 |
| EP1697374A1 (en) | 2006-09-06 |
| JP4926720B2 (ja) | 2012-05-09 |
| CN1938309B (zh) | 2011-11-09 |
| MY143499A (en) | 2011-05-31 |
| US20070287705A1 (en) | 2007-12-13 |
| US7737154B2 (en) | 2010-06-15 |
| AU2004309168B2 (en) | 2009-04-23 |
| JP2007515472A (ja) | 2007-06-14 |
| CN1938309A (zh) | 2007-03-28 |
| IS8526A (is) | 2006-07-11 |
| NO20063230L (no) | 2006-09-12 |
| KR20070009537A (ko) | 2007-01-18 |
| WO2005063755A1 (en) | 2005-07-14 |
| ZA200604574B (en) | 2007-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: SB PHARMCO PUERTO RICO INC. (US) , NEUROCRINE BIOS Free format text: TRANSFERIDO PARTE DOS DIREITOS DE: SB PHARMCO PUERTO RICO INC. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA: INT. CL. C07D 487/04; A61K 31/495; A61P 25/00 Ipc: C07D 487/04 (2011.01), A61K 31/495 (2011.01), A61P |
|
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |