BRPI0418051A2 - sistema de testes de medicamento com fígado bio-artificial - Google Patents

sistema de testes de medicamento com fígado bio-artificial

Info

Publication number
BRPI0418051A2
BRPI0418051A2 BRPI0418051A BRPI0418051A BRPI0418051A2 BR PI0418051 A2 BRPI0418051 A2 BR PI0418051A2 BR PI0418051 A BRPI0418051 A BR PI0418051A BR PI0418051 A BRPI0418051 A BR PI0418051A BR PI0418051 A2 BRPI0418051 A2 BR PI0418051A2
Authority
BR
Brazil
Prior art keywords
bio
testing system
drug testing
artificial liver
liver drug
Prior art date
Application number
BRPI0418051A
Other languages
English (en)
Inventor
Sung-Soo Park
Original Assignee
Hepahope Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hepahope Inc filed Critical Hepahope Inc
Publication of BRPI0418051A2 publication Critical patent/BRPI0418051A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BRPI0418051A 2003-12-16 2004-05-25 sistema de testes de medicamento com fígado bio-artificial BRPI0418051A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/738,905 US20050130254A1 (en) 2003-12-16 2003-12-16 Drug testing system with bio-artificial liver
PCT/US2004/016477 WO2005061694A1 (en) 2003-12-16 2004-05-25 Drug testing system with bio-artificial liver

Publications (1)

Publication Number Publication Date
BRPI0418051A2 true BRPI0418051A2 (pt) 2017-04-18

Family

ID=34654273

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418051A BRPI0418051A2 (pt) 2003-12-16 2004-05-25 sistema de testes de medicamento com fígado bio-artificial

Country Status (11)

Country Link
US (2) US20050130254A1 (pt)
EP (1) EP1697496A4 (pt)
JP (1) JP2007513638A (pt)
KR (1) KR20060127880A (pt)
CN (3) CN1894396A (pt)
AU (1) AU2004303755A1 (pt)
BR (1) BRPI0418051A2 (pt)
CA (1) CA2549904A1 (pt)
IL (1) IL176256A0 (pt)
WO (1) WO2005061694A1 (pt)
ZA (2) ZA200605435B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130254A1 (en) 2003-12-16 2005-06-16 Park Sung-Soo Drug testing system with bio-artificial liver
US20070048732A1 (en) * 2005-08-30 2007-03-01 Hepahope, Inc. Chemosensitivity tester
BRPI0615485A2 (pt) * 2005-08-24 2016-09-20 Hepahope Inc novos processo melhorados para testes e triagem de drogas utilizando tecidos humanos
KR20080056163A (ko) * 2005-08-24 2008-06-20 헤파호프 인코포레이티드 신규의 향상된 인체 조직을 사용한 약물 시험 및 선별 방법
EP1931988A4 (en) * 2005-08-24 2009-01-28 Hepahope Inc CHEMOSENSITIVITY TESTING APPARATUS
JP2009505662A (ja) * 2005-08-24 2009-02-12 ヘパホープ インコーポレイテッド 化学療法感受性試験機
WO2007085621A1 (de) * 2006-01-27 2007-08-02 Boehringer Ingelheim International Gmbh Verfahren und vorrichtung zur beaufschlagung von zellen
DE102006021406B4 (de) * 2006-05-08 2008-08-07 B.R.A.H.M.S Aktiengesellschaft In vitro Verfahren zur Früherkennung von arznei- und suchtmittelinduzierten Leberschäden und zur Erkennung der bereits erreichten Stufe der Leberschädigung
US8771930B2 (en) * 2007-05-18 2014-07-08 Lifeline Scientific, Inc. Ex vivo methods for testing toxicity of substances using donated human organs or tissues
CN102010821A (zh) * 2010-09-02 2011-04-13 天津开发区合普工贸有限公司 细胞气态暴露实验控制装置
CN102010822A (zh) * 2010-09-14 2011-04-13 天津开发区合普工贸有限公司 细胞培养液雾化供应装置
ITRM20110066A1 (it) * 2011-02-14 2012-08-15 Innate Pharma Sa Metodo in vitro per la coltivazione di virus epatitici per effettuare una valutazione rapida dell'efficacia della terapia antivirale
US8846576B2 (en) 2011-05-27 2014-09-30 Xenotech Llc In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
NL2007734C2 (nl) * 2011-11-07 2013-05-08 Tulip Life Science Products B V Inrichting voor het kweken van cellen.
EP2844733B1 (en) * 2012-04-18 2020-07-15 Hemoshear, LLC In vitro model for pathological or physiologic conditions
EP3060654B1 (en) 2013-10-21 2023-03-15 Hemoshear, LLC In vitro model for a tumor microenvironment
WO2018185760A1 (en) 2017-04-05 2018-10-11 Yeda Research And Development Co. Ltd. Ex-vivo culture system and methods of using same
WO2019168913A1 (en) * 2018-02-28 2019-09-06 Pop Test Oncology Llc Medical devices and uses thereof
WO2019217732A1 (en) * 2018-05-09 2019-11-14 EMULATE, Inc. Host- biome interactions
CN112154201B (zh) * 2018-05-22 2024-12-27 形态细胞科技公司 灌注生物反应器、灌注器件、人造肝脏系统及相关方法
KR102524249B1 (ko) * 2019-12-03 2023-04-20 더 유니버시티 오브 아델라이드 세포 배양 마이크로 디바이스

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308351A (en) 1980-04-18 1981-12-29 Joseph Leighton System for growing tissue cultures
US4559299A (en) 1983-02-04 1985-12-17 Brown University Research Foundation Inc. Cytotoxicity assays in cell culturing devices
US5866420A (en) * 1993-10-08 1999-02-02 The United States Of America As Represented By The Secretary Of Agriculture Artificial liver device
KR0129833B1 (ko) * 1994-11-09 1998-04-04 박성수 조직 배양 방법 및 장치
US5976870A (en) * 1994-11-09 1999-11-02 Park; Sung-Su Artificial liver composed of a liver-slice culture apparatus
JPH08163996A (ja) 1994-12-13 1996-06-25 Sumitomo Bakelite Co Ltd 動物細胞毒性試験方法
US5733285A (en) * 1995-07-13 1998-03-31 Fastenetix, Llc Polyaxial locking mechanism
JP4112616B2 (ja) 1995-10-06 2008-07-02 シード・キャピタル・インベストメンツ−２（エスシーアイ−２）・ビー・ブイ 細胞培養、特に肝細胞の培養に使用するための固相支持体、前記固相支持体を含む生物的リアクター、およびバイオ人工肝臓システムにおけるその使用
JP3452366B2 (ja) 1995-10-20 2003-09-29 トランスティッシュウ テクノロジーズ ゲーエムベーハー 新規人工組織、その製法およびその使用
US5827729A (en) 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
JP2002233361A (ja) 2001-02-06 2002-08-20 Ueda Seni Kagaku Shinkokai トリミング型ゲルを用いた肝組織切片培養法
US20040185558A1 (en) 2003-01-30 2004-09-23 Corinne Griguer Method for culturing brain tissue in three dimensions
US20050130254A1 (en) 2003-12-16 2005-06-16 Park Sung-Soo Drug testing system with bio-artificial liver
US20040265997A1 (en) 2003-06-27 2004-12-30 Park Sung-Soo Bio-artificial liver system
US6852505B1 (en) 2003-10-15 2005-02-08 Chau-Ting Yeh Hepatitis

Also Published As

Publication number Publication date
US7829325B2 (en) 2010-11-09
ZA200801829B (en) 2008-12-31
EP1697496A1 (en) 2006-09-06
JP2007513638A (ja) 2007-05-31
US20050282152A1 (en) 2005-12-22
EP1697496A4 (en) 2007-01-03
CN101268365A (zh) 2008-09-17
CN1894396A (zh) 2007-01-10
IL176256A0 (en) 2006-10-05
AU2004303755A1 (en) 2005-07-07
CA2549904A1 (en) 2005-07-07
CN101268364A (zh) 2008-09-17
ZA200605435B (en) 2007-11-28
WO2005061694A1 (en) 2005-07-07
KR20060127880A (ko) 2006-12-13
US20050130254A1 (en) 2005-06-16

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Legal Events

Date Code Title Description
B152 Others concerning applications: decision cancelled [chapter 15.32 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO ARQUIVAMENTO PUBLICADO NA RPI 2416 DE 25/04/2017.