BRPI0418245A - nitróxi-derivados de prostaglandina - Google Patents

nitróxi-derivados de prostaglandina

Info

Publication number
BRPI0418245A
BRPI0418245A BRPI0418245-6A BRPI0418245A BRPI0418245A BR PI0418245 A BRPI0418245 A BR PI0418245A BR PI0418245 A BRPI0418245 A BR PI0418245A BR PI0418245 A BRPI0418245 A BR PI0418245A
Authority
BR
Brazil
Prior art keywords
nitroxy
prostaglandin derivatives
derivatives
prostaglandin
glaucoma
Prior art date
Application number
BRPI0418245-6A
Other languages
English (en)
Inventor
Ennio Ongini
Francesca Benedini
Valerio Chiroli
Piero Del Soldato
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34778199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0418245(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of BRPI0418245A publication Critical patent/BRPI0418245A/pt
Publication of BRPI0418245B1 publication Critical patent/BRPI0418245B1/pt
Publication of BRPI0418245B8 publication Critical patent/BRPI0418245B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

"NITROXI-DERIVADOS DE PROSTAGLANDINA". São descritos nitróxi-derivados de prostaglandinas tendo atividade farmacológica aumentada e tolerabilidade melhorada. Eles podem ser empregados para o tratamento de glaucoma e de hipertensão ocular.
BRPI0418245A 2004-01-05 2004-12-27 composto derivado de nitróxi de prostaglandina, processo para preparar dito composto, composição farmacêutica compreendendo dito composto e usos destes BRPI0418245B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04100001 2004-01-05
PCT/EP2004/014820 WO2005068421A1 (en) 2004-01-05 2004-12-27 Prostaglandin nitrooxyderivatives

Publications (3)

Publication Number Publication Date
BRPI0418245A true BRPI0418245A (pt) 2007-04-17
BRPI0418245B1 BRPI0418245B1 (pt) 2017-05-30
BRPI0418245B8 BRPI0418245B8 (pt) 2021-05-25

Family

ID=34778199

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418245A BRPI0418245B8 (pt) 2004-01-05 2004-12-27 composto derivado de nitróxi de prostaglandina, processo para preparar dito composto, composição farmacêutica compreendendo dito composto e usos destes

Country Status (39)

Country Link
US (5) US7273946B2 (pt)
EP (3) EP1704141B1 (pt)
JP (1) JP3984283B2 (pt)
KR (2) KR100854838B1 (pt)
CN (1) CN100469765C (pt)
AP (1) AP2006003638A0 (pt)
AR (2) AR047081A1 (pt)
AU (1) AU2004313688B2 (pt)
BR (1) BRPI0418245B8 (pt)
CA (1) CA2551409C (pt)
CR (2) CR8498A (pt)
CY (1) CY1117417T1 (pt)
DK (1) DK1704141T3 (pt)
EA (1) EA010595B1 (pt)
EC (1) ECSP066684A (pt)
ES (2) ES2767136T3 (pt)
GE (1) GEP20094780B (pt)
GT (1) GT200500293A (pt)
HR (1) HRP20160500T1 (pt)
HU (1) HUE027357T2 (pt)
IL (1) IL176416A (pt)
MA (1) MA28284A1 (pt)
ME (1) ME02433B (pt)
MX (1) MXPA06007678A (pt)
MY (1) MY147181A (pt)
NO (2) NO337217B1 (pt)
NZ (1) NZ548271A (pt)
OA (1) OA13356A (pt)
PA (1) PA8620901A1 (pt)
PE (1) PE20051052A1 (pt)
PL (1) PL1704141T3 (pt)
RS (1) RS54717B1 (pt)
SI (1) SI1704141T1 (pt)
TN (1) TNSN06210A1 (pt)
TW (1) TWI337994B (pt)
UA (1) UA84726C2 (pt)
UY (1) UY28709A1 (pt)
WO (1) WO2005068421A1 (pt)
ZA (1) ZA200605354B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0418245B8 (pt) * 2004-01-05 2021-05-25 Nicox Sa composto derivado de nitróxi de prostaglandina, processo para preparar dito composto, composição farmacêutica compreendendo dito composto e usos destes
EP1917239A1 (en) * 2005-06-29 2008-05-07 Pfizer, Inc. Fluoroprostaglandins nitroderivatives
EP1899295A2 (en) * 2005-06-29 2008-03-19 Pfizer, Inc. Prostaglandin derivatives
AU2007243765A1 (en) * 2006-03-29 2007-11-08 Nicox S.A. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
DE102006052755A1 (de) * 2006-11-08 2008-05-15 N-Zyme Biotec Gmbh Michaelsysteme als Transglutaminaseinhibitoren
WO2008071421A1 (en) * 2006-12-15 2008-06-19 Nicox S.A. Nitrate esters of carbonic anhydrase inhibitors
WO2008075155A2 (en) 2006-12-15 2008-06-26 Nicox S.A. Carbonic anhydrase inhibitors derivatives
KR20150058566A (ko) 2007-06-04 2015-05-28 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 ｎｓａｉａ 약물전구체 및 이들의 새로운 의약적 용도
WO2009035565A1 (en) * 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Prostaglandin analogues for implant devices and methods
US7632867B2 (en) * 2007-10-31 2009-12-15 Meta Cosmetics, Llc Prostaglandin analog compositions to treat epithelial-related conditions
AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
BR122021011394B1 (pt) 2008-12-04 2021-09-28 Chongxi Yu Composição de alta penetração de um fármaco principal, e uso de uma hpc
KR101172638B1 (ko) 2008-12-30 2012-08-08 조선대학교산학협력단 신규한 티아졸리딘디온 유도체 및 그의 용도
WO2011032936A1 (en) * 2009-09-15 2011-03-24 Dsm Ip Assets B.V. Nitrooxyesters, their preparation and use
CN101885684B (zh) * 2010-07-01 2013-10-30 南京中医药大学 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用
EP3290024B1 (en) 2011-08-29 2019-04-17 Mati Therapeutics Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
HU231203B1 (hu) * 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
HK1222810A1 (zh) 2012-05-03 2017-07-14 麦提疗法有限公司 治疗开角型青光眼和高眼压症的药物递送系统和方法
EP2911656B1 (en) * 2012-10-23 2020-12-02 Nicox SA Quinone based nitric oxide donating compounds for ophthalmic use
JP6306148B2 (ja) * 2013-04-18 2018-04-04 ニコックス サイエンス アイルランド 点眼用のキノン系一酸化窒素供与性化合物
EP3091985B1 (en) 2014-01-10 2024-05-08 Manistee Therapeutics, Inc. Prostanglandins for topical use in the treatment of migraines.
CN112022856A (zh) * 2014-10-15 2020-12-04 爱尔康公司 用于治疗青光眼和眼压过高的前列腺素偶联物和衍生物
US10047047B2 (en) 2015-03-31 2018-08-14 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
US10280138B2 (en) 2015-03-31 2019-05-07 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
EP3088388A1 (en) 2015-04-30 2016-11-02 NicOx S.A. Nitric oxide donating derivatives of prostaglandins
KR20180058758A (ko) 2015-09-22 2018-06-01 그레이버그 비젼, 인크. 안구 장애의 치료를 위한 화합물 및 조성물
HU231175B1 (hu) * 2015-12-04 2021-06-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával
US11058691B2 (en) 2016-11-08 2021-07-13 Nicox S.A. Nitric oxide releasing prostaglandin derivatives for treating normal tension glaucoma
KR102069205B1 (ko) 2017-08-09 2020-01-22 연성정밀화학(주) 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체
RU2718744C2 (ru) 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
CN109988089B (zh) * 2018-05-29 2022-04-26 上海凡秦医药科技有限公司 一种前列腺素化合物、制备方法及其用途
CN108892624B (zh) * 2018-06-20 2020-12-15 重庆威鹏药业有限公司 沙库巴曲硝基氧衍生物及其制备方法和应用
US11332433B2 (en) * 2020-07-24 2022-05-17 Chirogate International Inc. Process for the preparation of latanoprostene bunod and intermediate thereof and compositions comprising the same
CN113943266A (zh) * 2021-11-18 2022-01-18 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
CN116444377A (zh) * 2022-01-07 2023-07-18 广州楷石医药有限公司 一种氧化氮供体型曲前列尼尔类衍生物及其药物组合物和用途
CA3195291A1 (en) * 2022-04-13 2023-10-13 Caravel Therapeutics, Inc. Preservative-free ophthalmic pharmaceutical emulsion and its application

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US3922293A (en) 1971-12-30 1975-11-25 Upjohn Co Prostaglandin F-type 9-monoacylates
US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
WO1990002553A1 (en) 1988-09-06 1990-03-22 Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
ATE153855T1 (de) 1992-10-13 1997-06-15 Alcon Lab Inc Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten
US5328933A (en) * 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
US5625083A (en) * 1995-06-02 1997-04-29 Bezuglov; Vladimir V. Dinitroglycerol esters of unsaturated fatty acids and prostaglandins
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1292377B1 (it) * 1997-06-19 1999-02-08 Nicox Sa Composizioni farmaceutiche a base di prostaglandine
US6417228B1 (en) 1998-11-02 2002-07-09 Alcon Manufacturing, Ltd.. 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
WO2000051978A1 (en) 1999-03-01 2000-09-08 Nitromed, Inc. Nitrosated and nitrosylated prostaglandins, compositions and metods of use
US20030018079A1 (en) 2000-11-13 2003-01-23 Richardson Helene Treatment
KR100875908B1 (ko) 2001-04-19 2008-12-26 테이카 세이야쿠 가부시키가이샤 약제 및 약제 키트
BRPI0418245B8 (pt) 2004-01-05 2021-05-25 Nicox Sa composto derivado de nitróxi de prostaglandina, processo para preparar dito composto, composição farmacêutica compreendendo dito composto e usos destes

Also Published As

Publication number Publication date
CN1906159A (zh) 2007-01-31
NO339685B1 (no) 2017-01-23
KR20060113753A (ko) 2006-11-02
UA84726C2 (ru) 2008-11-25
EA200601099A1 (ru) 2006-10-27
WO2005068421A8 (en) 2006-02-09
BRPI0418245B1 (pt) 2017-05-30
PL1704141T3 (pl) 2016-08-31
EP3002277B1 (en) 2019-11-06
HK1096084A1 (zh) 2007-05-25
NZ548271A (en) 2010-01-29
US7910767B2 (en) 2011-03-22
MXPA06007678A (es) 2006-09-01
CA2551409C (en) 2011-02-22
JP3984283B2 (ja) 2007-10-03
US7273946B2 (en) 2007-09-25
NO337217B1 (no) 2016-02-15
KR100854838B1 (ko) 2008-08-29
HUE027357T2 (en) 2016-09-28
HRP20160500T1 (hr) 2016-06-03
DK1704141T3 (en) 2016-05-02
CR20110131A (es) 2011-03-30
US7449469B2 (en) 2008-11-11
US20080058392A1 (en) 2008-03-06
MY147181A (en) 2012-11-14
EP1704141B1 (en) 2016-02-24
MA28284A1 (fr) 2006-11-01
CN100469765C (zh) 2009-03-18
ES2767136T3 (es) 2020-06-16
EP3643702A1 (en) 2020-04-29
ES2566800T3 (es) 2016-04-15
ZA200605354B (en) 2009-09-30
SI1704141T1 (sl) 2016-04-29
UY28709A1 (es) 2005-08-31
PE20051052A1 (es) 2005-12-17
OA13356A (en) 2007-04-13
CY1117417T1 (el) 2017-04-26
US8058467B2 (en) 2011-11-15
NO20151341A1 (no) 2006-09-07
AP2006003638A0 (en) 2006-06-30
KR100850133B1 (ko) 2008-08-04
TWI337994B (en) 2011-03-01
CR8498A (es) 2006-11-15
US20090030076A1 (en) 2009-01-29
US20110136904A1 (en) 2011-06-09
AR047081A1 (es) 2006-01-04
GEP20094780B (en) 2009-09-25
ME02433B (me) 2016-09-20
BRPI0418245B8 (pt) 2021-05-25
PA8620901A1 (es) 2005-08-30
EP1704141A1 (en) 2006-09-27
EP3002277A1 (en) 2016-04-06
AU2004313688A1 (en) 2005-07-28
IL176416A (en) 2013-05-30
US20050272743A1 (en) 2005-12-08
AU2004313688B2 (en) 2010-08-05
TNSN06210A1 (fr) 2007-12-03
KR20080007415A (ko) 2008-01-18
US20100130507A1 (en) 2010-05-27
AR098931A2 (es) 2016-06-22
US7629345B2 (en) 2009-12-08
CA2551409A1 (en) 2005-07-28
TW200526567A (en) 2005-08-16
JP2007518716A (ja) 2007-07-12
EA010595B1 (ru) 2008-10-30
NO20063567L (no) 2006-09-07
RS54717B1 (sr) 2016-08-31
ECSP066684A (es) 2006-10-25
WO2005068421A1 (en) 2005-07-28
GT200500293A (es) 2007-07-06
IL176416A0 (en) 2006-10-05

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