BRPI0418651A - compostos com base em lisina - Google Patents

compostos com base em lisina

Info

Publication number
BRPI0418651A
BRPI0418651A BRPI0418651-6A BRPI0418651A BRPI0418651A BR PI0418651 A BRPI0418651 A BR PI0418651A BR PI0418651 A BRPI0418651 A BR PI0418651A BR PI0418651 A BRPI0418651 A BR PI0418651A
Authority
BR
Brazil
Prior art keywords
based compounds
lysine based
cycloalkyl
alkyl
lysine
Prior art date
Application number
BRPI0418651-6A
Other languages
English (en)
Inventor
Brent Richard Stranix
Valerie Perron
Original Assignee
Ambrilia Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrilia Biopharma Inc filed Critical Ambrilia Biopharma Inc
Publication of BRPI0418651A publication Critical patent/BRPI0418651A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/41—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSTOS COM BASE EM LISINA. A presente invenção fornece compostos com base em lisina da fórmula (l); e quando o composto da fórmula (l) compreende um grupo amina, sais de amónio farmaceuticamente aceitáveis do mesmo, em que R~ 1~ pode ser, por exemplo, (HO)~ 2~P(O)- (NaO)~ 2~P(O)-, ou cicloalquil-CO-, em que X pode ser, por exemplo, F, Cl e Br e em que R~ 2~ e R~ 3~ são como definidos aqui.
BRPI0418651-6A 2004-08-02 2004-08-02 compostos com base em lisina BRPI0418651A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CA2004/001440 WO2006012725A1 (en) 2004-08-02 2004-08-02 Lysine based compounds

Publications (1)

Publication Number Publication Date
BRPI0418651A true BRPI0418651A (pt) 2007-05-29

Family

ID=35786842

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418651-6A BRPI0418651A (pt) 2004-08-02 2004-08-02 compostos com base em lisina

Country Status (14)

Country Link
EP (2) EP2165709B1 (pt)
JP (1) JP4579970B2 (pt)
CN (1) CN1942436B (pt)
AT (1) ATE417823T1 (pt)
AU (2) AU2004322123B2 (pt)
BR (1) BRPI0418651A (pt)
CA (1) CA2560071C (pt)
DE (1) DE602004018548D1 (pt)
ES (2) ES2319996T3 (pt)
IL (1) IL180958A0 (pt)
MX (1) MX2007001278A (pt)
NO (1) NO20071152L (pt)
RU (1) RU2009139259A (pt)
WO (1) WO2006012725A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7388008B2 (en) 2004-08-02 2008-06-17 Ambrilia Biopharma Inc. Lysine based compounds
WO2006012725A1 (en) 2004-08-02 2006-02-09 Ambrilia Biopharma Inc. Lysine based compounds
CN101405293B (zh) * 2005-11-30 2013-03-13 中裕新药股份有限公司 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法
AU2007287353A1 (en) * 2006-07-17 2008-02-28 Ambrilia Biopharma Inc. Method for improving pharmacokinetics
US8410300B2 (en) 2006-09-21 2013-04-02 Taimed Biologics, Inc. Protease inhibitors
WO2009148600A2 (en) * 2008-06-06 2009-12-10 Concert Pharmaceuticals, Inc. Deuterated lysine-based compounds
CA2762582A1 (en) 2009-05-27 2010-12-02 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2012055031A1 (en) 2010-10-28 2012-05-03 Merck Canada Inc. Hiv protease inhibitors
US9187415B2 (en) 2010-10-29 2015-11-17 Merck Canada Inc. Sulfonamides as HIV protease inhibitors
EP2771332B1 (en) 2011-10-26 2016-06-29 Merck Canada Inc. Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436989B1 (en) * 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
CA2405151A1 (en) * 2000-04-07 2001-10-18 University Of Maryland, Baltimore Bile acid containing prodrugs with enhanced bioavailability
US6617310B2 (en) * 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
WO2002016395A1 (en) * 2000-08-18 2002-02-28 The Board Of Trustees Of The University Of Illinois Prodrugs of betulinic acid derivatives for the treatment of cancer and hiv
US6506786B2 (en) * 2001-02-13 2003-01-14 Pharmacor Inc. HIV protease inhibitors based on amino acid derivatives
US6632816B1 (en) * 2002-12-23 2003-10-14 Pharmacor Inc. Aromatic derivatives as HIV aspartyl protease inhibitors
WO2006012725A1 (en) 2004-08-02 2006-02-09 Ambrilia Biopharma Inc. Lysine based compounds

Also Published As

Publication number Publication date
EP2165709A2 (en) 2010-03-24
EP2165709B1 (en) 2016-03-16
ES2575871T3 (es) 2016-07-01
HK1105406A1 (en) 2008-02-15
EP1773763A1 (en) 2007-04-18
JP4579970B2 (ja) 2010-11-10
CN1942436B (zh) 2011-03-23
CA2560071C (en) 2012-09-25
EP1773763A4 (en) 2007-08-08
IL180958A0 (en) 2007-07-04
JP2007525527A (ja) 2007-09-06
ATE417823T1 (de) 2009-01-15
EP1773763B1 (en) 2008-12-17
WO2006012725A1 (en) 2006-02-09
EP2165709A3 (en) 2010-06-23
RU2009139259A (ru) 2011-04-27
NO20071152L (no) 2007-03-01
DE602004018548D1 (de) 2009-01-29
AU2009230800A1 (en) 2009-11-19
CN1942436A (zh) 2007-04-04
ES2319996T3 (es) 2009-05-18
MX2007001278A (es) 2007-09-14
CA2560071A1 (en) 2006-02-09
AU2004322123A1 (en) 2006-02-09
AU2004322123B2 (en) 2009-08-13

Similar Documents

Publication Publication Date Title
NO20071152L (no) Lysinbaserte forbindelser
ATE529491T1 (de) Zusammensetzungen mit fluorsubsttuierten olefinen
BE2018C008I2 (pt)
SE0300956D0 (sv) Stabilisatorblandningar
SI1392642T1 (sl) Nove spojine kot protivnetna, imunomodulacijska in antiproliferativna sredstva
BR0211844A (pt) Composto e ativador de receptor delta ativado por proliferador e peroxissoma
CY1106247T1 (el) Θειοφαινο- και θειαζολοσουλφοναμιδες ως αντινεοπλαστικοι παραγοντες
EP1795536A4 (en) PHOSPHORAMIDITE COMPOUND AND PROCESS FOR THE PREPARATION OF OLIGO RNA
CY1105386T1 (el) Βενζοϋλοσουλφοναμιδια και σουλφονυλβενζαμιδινες για χρηση σαν παραγοντες κατα του ογκου
NZ596107A (en) Antiviral compounds and methods
DE60239884D1 (de) Pyrimidinverbindung und diese enthaltende medizinische zusammensetzung
DE60228990D1 (de) Bicyclische verbindung
AR036472A1 (es) Derivados de azetidina, procedimientos para su preparacion y su empleo como agentes pesticidas
TW200600971A (en) Calixresorcinarene compounds, photoresist base materials, and compositions thereof
ATE504592T1 (de) Trehaloseverbindung und arzneimittel mit der verbindung
DE60223904D1 (de) Benzylaminanalogen
BR0117191A (pt) Composições nanoparticuladas de isotretinoina
EP2116531A4 (en) CBP CONNECTION
EA200801365A1 (ru) Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины
DE60208477D1 (de) Wasser- und Öl-abweisende Zusammensetzung und daraus gebildeter Formkörper
DK1072601T3 (da) 4-Arylpiperidinderivater til behandling af pruritus
DE602005003163D1 (de) Siliciumhaltige Verbindung, Zusammensetzung und Isolierfilm
NO20004477D0 (no) Anvendelse av organiske karbonater som løsningsmidler for vasking av metalloverflater
ATE481390T1 (de) Pyrazolverbindung
NO20053997L (no) Oligosaccharidderivat

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.