BRPI0418760A - processo estereosseletivo para a preparação de clopidogrel - Google Patents
processo estereosseletivo para a preparação de clopidogrelInfo
- Publication number
- BRPI0418760A BRPI0418760A BRPI0418760-1A BRPI0418760A BRPI0418760A BR PI0418760 A BRPI0418760 A BR PI0418760A BR PI0418760 A BRPI0418760 A BR PI0418760A BR PI0418760 A BRPI0418760 A BR PI0418760A
- Authority
- BR
- Brazil
- Prior art keywords
- diastereomers
- halo
- mixture
- formulae
- substituted
- Prior art date
Links
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 title 1
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 title 1
- 229960003009 clopidogrel Drugs 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- 125000005842 heteroatom Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000000203 mixture Substances 0.000 abstract 6
- 125000005843 halogen group Chemical group 0.000 abstract 5
- -1 6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl Chemical group 0.000 abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001414 amino alcohols Chemical class 0.000 abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001555 benzenes Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- NCXUNZWLEYGQAH-UHFFFAOYSA-N 1-(dimethylamino)propan-2-ol Chemical compound CC(O)CN(C)C NCXUNZWLEYGQAH-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 239000003705 antithrombocytic agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- 230000002537 thrombolytic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Semiconductor Lasers (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCESSO ESTEREOSSELETIVO PARA A PREPARAçãO DE CLOPIDOGREL. A presente invenção refere-se aos processos para a preparação de um composto da fórmula geral (?a) em que x é um átomo de halogênio, ou um sal farmaceuticamente aceitável deste, em que um composto da fórmula (??) em que x é como definido acima e Y e Z independentemente representam um grupo de partida cada, é reagido com um amino álcool oticamente ativo para formar uma primeira mistura de diastereómeros.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04009280A EP1589019B1 (de) | 2004-04-20 | 2004-04-20 | Stereoselektives Verfahren zur Herstellung von Clopidogrel |
| PCT/EP2004/013773 WO2005113559A1 (de) | 2004-04-20 | 2004-12-03 | Stereoselektives verfahren zur herstellung von clopidogrel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0418760A true BRPI0418760A (pt) | 2007-10-09 |
Family
ID=34924660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0418760-1A BRPI0418760A (pt) | 2004-04-20 | 2004-12-03 | processo estereosseletivo para a preparação de clopidogrel |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7507827B2 (pt) |
| EP (2) | EP1589019B1 (pt) |
| JP (1) | JP2007533671A (pt) |
| CN (1) | CN100522970C (pt) |
| AT (2) | ATE404566T1 (pt) |
| AU (1) | AU2004319901A1 (pt) |
| BR (1) | BRPI0418760A (pt) |
| CA (1) | CA2563662A1 (pt) |
| CY (2) | CY1107908T1 (pt) |
| DE (2) | DE502004007831D1 (pt) |
| DK (2) | DK1589019T3 (pt) |
| ES (2) | ES2309416T3 (pt) |
| HR (1) | HRP20080091T3 (pt) |
| NO (1) | NO20065313L (pt) |
| PL (2) | PL1589019T3 (pt) |
| PT (2) | PT1589019E (pt) |
| RU (1) | RU2369610C2 (pt) |
| SI (2) | SI1589019T1 (pt) |
| UA (1) | UA93030C2 (pt) |
| WO (1) | WO2005113559A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2909377A1 (fr) | 2006-12-05 | 2008-06-06 | Arkema France | Procede de synthese d'esters (meth)acryliques catalyse par un titanate de polyol |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1196334B (it) * | 1984-11-22 | 1988-11-16 | Alfa Chem Ital | Processo per la risoluzione ottica di miscugli racemi di acidi alfanaftil-propionici |
| DE4428531A1 (de) * | 1994-08-12 | 1996-02-15 | Boehringer Ingelheim Kg | Neue enantiomerenreine Pyridylcycloalkylethylamine und deren Salze sowie Verfahren zu ihrer Herstellung |
| HU225503B1 (en) * | 1997-05-13 | 2007-01-29 | Sanofi Aventis | Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them |
| HU222283B1 (hu) * | 1997-05-13 | 2003-05-28 | Sanofi-Synthelabo | Eljárás tieno[3,2-c]piridin-származékok előállítására |
| FR2769313B1 (fr) * | 1997-10-06 | 2000-04-21 | Sanofi Sa | Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese |
| AU2001230583A1 (en) * | 2000-02-08 | 2001-08-20 | Asahi Kasei Kabushiki Kaisha | Process for preparing optically active secondary alcohols having nitrogenous or oxygenic functional groups |
| GB0125708D0 (en) * | 2001-10-26 | 2001-12-19 | Generics Uk Ltd | Novel compounds and processes |
-
2004
- 2004-04-20 ES ES04009280T patent/ES2309416T3/es not_active Expired - Lifetime
- 2004-04-20 DK DK04009280T patent/DK1589019T3/da active
- 2004-04-20 DE DE502004007831T patent/DE502004007831D1/de not_active Expired - Lifetime
- 2004-04-20 EP EP04009280A patent/EP1589019B1/de not_active Expired - Lifetime
- 2004-04-20 PT PT04009280T patent/PT1589019E/pt unknown
- 2004-04-20 AT AT04009280T patent/ATE404566T1/de not_active IP Right Cessation
- 2004-04-20 SI SI200430861T patent/SI1589019T1/sl unknown
- 2004-04-20 PL PL04009280T patent/PL1589019T3/pl unknown
- 2004-12-03 PL PL04803495T patent/PL1737868T3/pl unknown
- 2004-12-03 BR BRPI0418760-1A patent/BRPI0418760A/pt not_active Application Discontinuation
- 2004-12-03 CN CNB2004800433958A patent/CN100522970C/zh not_active Expired - Fee Related
- 2004-12-03 AT AT04803495T patent/ATE387454T1/de active
- 2004-12-03 CA CA002563662A patent/CA2563662A1/en not_active Abandoned
- 2004-12-03 DK DK04803495T patent/DK1737868T3/da active
- 2004-12-03 WO PCT/EP2004/013773 patent/WO2005113559A1/de not_active Ceased
- 2004-12-03 JP JP2007508735A patent/JP2007533671A/ja active Pending
- 2004-12-03 DE DE502004006368T patent/DE502004006368D1/de not_active Expired - Lifetime
- 2004-12-03 HR HR20080091T patent/HRP20080091T3/xx unknown
- 2004-12-03 PT PT04803495T patent/PT1737868E/pt unknown
- 2004-12-03 AU AU2004319901A patent/AU2004319901A1/en not_active Abandoned
- 2004-12-03 US US11/587,124 patent/US7507827B2/en not_active Expired - Fee Related
- 2004-12-03 SI SI200430682T patent/SI1737868T1/sl unknown
- 2004-12-03 UA UAA200611996A patent/UA93030C2/ru unknown
- 2004-12-03 ES ES04803495T patent/ES2300854T3/es not_active Expired - Lifetime
- 2004-12-03 RU RU2006137112/04A patent/RU2369610C2/ru not_active IP Right Cessation
- 2004-12-03 EP EP04803495A patent/EP1737868B1/de not_active Expired - Lifetime
-
2006
- 2006-11-20 NO NO20065313A patent/NO20065313L/no not_active Application Discontinuation
-
2008
- 2008-03-18 CY CY20081100304T patent/CY1107908T1/el unknown
- 2008-10-02 CY CY20081101094T patent/CY1108391T1/el unknown
-
2009
- 2009-02-10 US US12/368,967 patent/US7799952B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |