BRPI0418845A - uso de compostos de kauranes na fabricação de medicamentos - Google Patents
uso de compostos de kauranes na fabricação de medicamentosInfo
- Publication number
- BRPI0418845A BRPI0418845A BRPI0418845-4A BRPI0418845A BRPI0418845A BR PI0418845 A BRPI0418845 A BR PI0418845A BR PI0418845 A BRPI0418845 A BR PI0418845A BR PI0418845 A BRPI0418845 A BR PI0418845A
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxyl
- compounds
- methyl
- ester
- manufacture
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000003618 kaurane group Chemical group 0.000 title 1
- -1 methyl hydroxyl Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010061216 Infarction Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001266 acyl halides Chemical class 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 150000007942 carboxylates Chemical class 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- ONVABDHFQKWOSV-HPUSYDDDSA-N ent-kaur-16-ene Chemical class C1C[C@H](C2)C(=C)C[C@@]32CC[C@@H]2C(C)(C)CCC[C@@]2(C)[C@@H]31 ONVABDHFQKWOSV-HPUSYDDDSA-N 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
USO DE COMPOSTOS DE KAURANES NA FABRICAçãO DE MEDICAMENTOS. A invenção refere-se ao uso farmacêutico de compostos de kaurene da fórmula (I) no tratamento e prevenção de doença coronária, acidente vascular cerebral, arritmia e isquemia cerebral etc. Os referidos compostos também têm efeitos protetores significantes contra infarto isquêmico cerebral, em que R¬ 1¬: hidrogênio, hidroxila ou alcóxi, R¬ 2¬: carboxila, carboxilato, haletos de acila, aldeído, metilidroxila, e grupo de éster, acilamida, acila ou éter hidrolisável por carboxila, R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 6¬, R¬ 8¬: independentemente, oxigênio, hidroxila, meti-lidroxila, e éster ou grupo de alquiloximetila hidrolisável por metilldroxila, R¬ 7¬: metila, hidroxila e éster ou alquiloximetila hidrolisável por metilidroxila, R¬ 9¬: metileno ou oxigênio.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2004/000508 WO2005110383A1 (fr) | 2004-05-19 | 2004-05-19 | Utilisation de composes de kaurane dans l'elaboration d'un medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0418845A true BRPI0418845A (pt) | 2007-11-13 |
Family
ID=35393975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0418845-4A BRPI0418845A (pt) | 2004-05-19 | 2004-05-19 | uso de compostos de kauranes na fabricação de medicamentos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9125877B2 (pt) |
| EP (1) | EP1757282B1 (pt) |
| JP (1) | JP2007538016A (pt) |
| CN (1) | CN100508962C (pt) |
| AU (1) | AU2004319792A1 (pt) |
| BR (1) | BRPI0418845A (pt) |
| CA (1) | CA2606472A1 (pt) |
| MX (1) | MXPA06013503A (pt) |
| WO (1) | WO2005110383A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101633609B (zh) * | 2009-08-12 | 2013-11-06 | 曹庸 | 一种从山莓叶中分离出的新化合物、制备方法及用途 |
| CN104529811A (zh) * | 2013-11-18 | 2015-04-22 | 福建医科大学 | 对映贝壳杉衍生物及其制备方法和应用 |
| CN107073022B (zh) * | 2014-10-31 | 2020-12-29 | 弗雷森纽斯医疗护理德国有限责任公司 | 包含甜菊苷的药物组合物 |
| WO2016077581A1 (en) * | 2014-11-12 | 2016-05-19 | University Of Florida Research Foundation, Inc. | Isosteviol triazoles and uses thereof |
| CN112716929B (zh) * | 2015-09-10 | 2023-03-31 | 东莞市凯法生物医药有限公司 | 贝壳杉烷类化合物在治疗心室增大及重构的药物应用 |
| CN109925302A (zh) * | 2019-02-18 | 2019-06-25 | 东莞市凯法生物医药有限公司 | 一种使用贝壳杉烷类化合物保护蒽环类抗肿瘤药物心脏毒性的应用 |
| AU2020276233A1 (en) * | 2019-05-13 | 2022-02-10 | Key Pharma Biomedical Inc. | New kaurane analogues,their preparation and therapeutically uses |
| CN115137718A (zh) * | 2020-11-15 | 2022-10-04 | 珠海沅芷健康科技有限公司 | 一种制备恢复心脏肥厚病中减低的CNPase活性的药物的方法 |
| CN113845424B (zh) * | 2021-10-14 | 2023-09-12 | 南京医科大学 | 右崁醇酯类化合物及其药物用途 |
| CN114917237A (zh) * | 2022-05-13 | 2022-08-19 | 葛鹏飞 | 莱苞迪甙a在制备预防和/或治疗脑缺血所致神经元损伤药物中的应用 |
| CN119015328A (zh) * | 2023-05-23 | 2024-11-26 | 北京大学 | 贝壳杉提取物在制备抗脓毒症急性肺损伤的产品中的应用 |
| CN118388348B (zh) * | 2024-06-20 | 2024-12-27 | 广东工业大学 | 一种甜菊醇衍生物及其制备方法和应用 |
| CN120518497B (zh) * | 2025-07-23 | 2025-10-14 | 广东工业大学 | 一种c-19位修饰的异甜菊醇衍生物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002037716A (ja) * | 2000-07-24 | 2002-02-06 | Shiseido Co Ltd | カウレン類含有組成物、養毛剤及び皮膚外用剤 |
| KR100383149B1 (ko) * | 2000-12-12 | 2003-05-12 | 한국생명공학연구원 | 디테르펜계 화합물을 염증질환, 면역질환 및 암 치료제로사용하는 신규한 용도 |
| EP1361870A2 (en) * | 2001-02-01 | 2003-11-19 | Nutri Pharma ASA | A substance for use in a dietary supplement or for the preparation of a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome |
-
2004
- 2004-05-19 EP EP04738166.0A patent/EP1757282B1/en not_active Expired - Lifetime
- 2004-05-19 CA CA 2606472 patent/CA2606472A1/en not_active Abandoned
- 2004-05-19 MX MXPA06013503A patent/MXPA06013503A/es active IP Right Grant
- 2004-05-19 JP JP2007516940A patent/JP2007538016A/ja active Pending
- 2004-05-19 AU AU2004319792A patent/AU2004319792A1/en not_active Abandoned
- 2004-05-19 US US11/596,514 patent/US9125877B2/en active Active
- 2004-05-19 WO PCT/CN2004/000508 patent/WO2005110383A1/zh not_active Ceased
- 2004-05-19 CN CNB2004800430678A patent/CN100508962C/zh not_active Expired - Fee Related
- 2004-05-19 BR BRPI0418845-4A patent/BRPI0418845A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005110383A1 (fr) | 2005-11-24 |
| CN100508962C (zh) | 2009-07-08 |
| EP1757282B1 (en) | 2015-02-25 |
| EP1757282A4 (en) | 2010-02-10 |
| EP1757282A1 (en) | 2007-02-28 |
| CA2606472A1 (en) | 2005-11-24 |
| US20100179097A1 (en) | 2010-07-15 |
| AU2004319792A1 (en) | 2005-11-24 |
| JP2007538016A (ja) | 2007-12-27 |
| US9125877B2 (en) | 2015-09-08 |
| MXPA06013503A (es) | 2007-06-12 |
| CN1997358A (zh) | 2007-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0418845A (pt) | uso de compostos de kauranes na fabricação de medicamentos | |
| BR0116607A (pt) | Derivados de glicopiranosiloxipirazol e uso dos mesmos em medicamentos | |
| BR0107147A (pt) | Composições farmacêuticas de drogas anti-tuberculosas e processo para as suas preparações | |
| HN2005000255A (es) | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis | |
| DK1289517T3 (da) | Farmaceutiske sammensætninger indeholdende cannabidiolderivater | |
| AR002974A1 (es) | Utilización de por lo menos un antagonista de cgrppara la preparación de una composición cosmética, farmacéutica y/o dermatológica para tratar las manchas rojas cutáneas de origen neurógeno, composición obtenida y procedimiento de tratamiento cosmético empleando dicho antagonista. | |
| DZ3227A1 (fr) | Compositions pharmaceutiques fournissant des concentrations de medicaments ameliorees | |
| BR0112591A (pt) | Derivados de acridina e sua aplicação como medicamento | |
| BR9914360A (pt) | N-aralquilaminotetralinas como ligandos para oreceptor neuropeptìdeo yy5 | |
| WO2001090091A8 (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
| TNSN08505A1 (fr) | Compositions pharmaceutiques stabilisees comprenant de la fesoterodine | |
| ES2178430T3 (es) | Utilizacion de composiciones farmaceuticas gelificables en parodontologia. | |
| TNSN06439A1 (fr) | Derives de 2-carbamide -4-phenylthiazole, leur preparation et leur application en therapeutique | |
| BRPI0517701A (pt) | uso de um composto na preparação de medicamentos para o tratamento de diabetes mellitus | |
| CL2007003587A1 (es) | Compuestos derivados de pirimidinas sustituidas; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para tratar o prevenir la infeccion de la hepatitis c. | |
| BR0008292A (pt) | Derivados de mevinolina | |
| WO2009064023A8 (en) | Skin moisturizer, blood circulation promoter, and external preparations for the skin containing the skin moisturizer and the blood circulation promoter | |
| EP2050442A4 (en) | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND / OR TREATMENT OF BONE DISORDERS, FUNCTIONAL FOOD OR HEALTH MEASURES CONTAINING THIS COMPOSITION AND PHARMACEUTICAL PREPARATION CONTAINING THE COMPOSITION AS AN ACTIVE SUBSTANCE | |
| EP1545479A4 (en) | EZETIMIB COMPOSITIONS AND METHOD FOR THE TREATMENT OF CHOLESTERIN-ASSOCIATED GOOD AND EVIL TUMORS | |
| ES2136581B1 (es) | Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb. | |
| ATE418540T1 (de) | Galloylpeptide | |
| BRPI0410840A (pt) | derivados substituìdos de pirrol, composição farmacêutica contendo os mesmos e processo para sua preparação | |
| Belmessieri et al. | Dodecyl sorbitan ethers as antimicrobials against Gram-positive bacteria | |
| BR0013723A (pt) | Uso de bissulfonamidas, para produção de medicamentos para profilaxia ou tratamento de hiperlipidemia | |
| WO2008043974A3 (fr) | Produits de soin cutané à double compartiment comprenant de l' ivermectine, et leurs utilisations |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |