BRPI0500395A - Processo para a sìntese de (7-metóxi-1-naftil)acetonitrila e sua aplicação na sìntese de agomelatina - Google Patents

Processo para a sìntese de (7-metóxi-1-naftil)acetonitrila e sua aplicação na sìntese de agomelatina

Info

Publication number
BRPI0500395A
BRPI0500395A BR0500395-4A BRPI0500395A BRPI0500395A BR PI0500395 A BRPI0500395 A BR PI0500395A BR PI0500395 A BRPI0500395 A BR PI0500395A BR PI0500395 A BRPI0500395 A BR PI0500395A
Authority
BR
Brazil
Prior art keywords
synthesis
application
methoxy
agomelatine
naphthyl
Prior art date
Application number
BR0500395-4A
Other languages
English (en)
Inventor
Jean-Claude Souvie
Isaac Gonzalez Blanco
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0500395A publication Critical patent/BRPI0500395A/pt
Publication of BRPI0500395B1 publication Critical patent/BRPI0500395B1/pt
Publication of BRPI0500395B8 publication Critical patent/BRPI0500395B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B37/00—Nuts or like thread-engaging members
    • F16B37/14—Cap nuts; Nut caps or bolt caps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA A SìNTESE DE (7-METóXI-1-NAFTIL)ACETONITRILA E SUA APLICAçãO NA SìNTESE DE AGOMELATINA". Processo para a síntese industrial do composto de fórmula (I) Aplicação na síntese de agomelatina.
BRPI0500395A 2004-02-13 2005-02-14 processo para a síntese de (7-metóxi-1-naftil)acetonitrila e sua aplicação na síntese de agomelatina BRPI0500395B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0401438 2004-02-13
FR0401438A FR2866334B1 (fr) 2004-02-13 2004-02-13 Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine

Publications (3)

Publication Number Publication Date
BRPI0500395A true BRPI0500395A (pt) 2005-09-27
BRPI0500395B1 BRPI0500395B1 (pt) 2018-11-06
BRPI0500395B8 BRPI0500395B8 (pt) 2021-05-25

Family

ID=34685018

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0500395A BRPI0500395B8 (pt) 2004-02-13 2005-02-14 processo para a síntese de (7-metóxi-1-naftil)acetonitrila e sua aplicação na síntese de agomelatina

Country Status (32)

Country Link
US (2) US7476751B2 (pt)
EP (1) EP1564203B1 (pt)
JP (1) JP4252040B2 (pt)
KR (1) KR100682697B1 (pt)
CN (1) CN1315794C (pt)
AR (1) AR047667A1 (pt)
AT (1) ATE452873T1 (pt)
AU (1) AU2005200620B8 (pt)
BR (1) BRPI0500395B8 (pt)
CA (1) CA2495960C (pt)
CY (1) CY1109737T1 (pt)
DE (1) DE602005018403D1 (pt)
DK (1) DK1564203T3 (pt)
EA (1) EA007789B1 (pt)
ES (1) ES2338664T3 (pt)
FR (1) FR2866334B1 (pt)
GE (1) GEP20063961B (pt)
HR (1) HRP20100103T1 (pt)
MA (1) MA27517A1 (pt)
ME (1) ME01806B (pt)
MX (1) MXPA05001634A (pt)
MY (2) MY142270A (pt)
NO (1) NO333488B1 (pt)
NZ (1) NZ538192A (pt)
PL (1) PL1564203T3 (pt)
PT (1) PT1564203E (pt)
RS (1) RS51212B (pt)
SG (1) SG114702A1 (pt)
SI (1) SI1564203T1 (pt)
UA (1) UA79479C2 (pt)
WO (1) WO2005077890A1 (pt)
ZA (1) ZA200501256B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2866336B1 (fr) * 2004-02-13 2006-03-24 Servier Lab Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine
CN101161638B (zh) * 2006-10-13 2010-09-29 北京德众万全药物技术开发有限公司 一种新的阿戈美拉汀重要中间体的制备方法
CN101585779B (zh) * 2009-03-10 2014-04-02 上海医药工业研究院 阿戈美拉汀的晶型vi及其制备方法和应用
CN101723855B (zh) * 2009-12-03 2012-08-08 浙江科技学院 一种(7-甲氧基-1-萘基)乙腈的合成方法
CN101792400B (zh) * 2010-03-16 2013-01-30 华东师范大学 一种阿戈美拉汀的合成方法
CN102276492B (zh) 2010-06-08 2013-04-10 上海医药工业研究院 阿戈美拉汀中间体及其制备方法
WO2011154140A2 (en) 2010-06-10 2011-12-15 Gador S.A. New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide and new crystalline form
CN102060733B (zh) * 2010-12-06 2014-01-29 威海迪素制药有限公司 (7-甲氧基-3,4-二氢-1-萘基)乙腈的制备方法
FR2970000B1 (fr) 2011-01-05 2013-01-04 Servier Lab Nouveau procede de synthese de l'agomelatine
WO2013054273A2 (en) 2011-10-11 2013-04-18 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
EP2785681A1 (en) 2011-12-01 2014-10-08 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
CN103319370B (zh) * 2012-03-21 2016-08-03 黑龙江福和华星制药集团股份有限公司 一种(7-甲氧基-1-萘基)乙腈的制备方法
ITMI20121444A1 (it) 2012-08-27 2014-02-28 Procos Spa Processo per la produzione di agomelatine
CN102875415B (zh) * 2012-10-09 2014-08-20 江西同和药业有限责任公司 一种化合物及其制备方法和应用
CN102875408B (zh) * 2012-10-09 2014-07-16 江西同和药业有限责任公司 一种阿戈美拉汀的制备方法
WO2016046833A2 (en) * 2014-09-24 2016-03-31 Symed Labs Limited Improved processes for the preparation of agomelatine using novel intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327022A (en) * 1973-08-16 1982-04-27 Sterling Drug Inc. Heterocyclic alkyl naphthols
US3931188A (en) * 1974-05-06 1976-01-06 Bristol-Myers Company 3-Hydroxy-5,6-benzomorphinan derivatives
US3992403A (en) * 1975-05-30 1976-11-16 Schering Corporation 2-Imidazolines and their use as hypoglycemic agents
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866335B1 (fr) * 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2866336B1 (fr) * 2004-02-13 2006-03-24 Servier Lab Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine

Also Published As

Publication number Publication date
JP2005239718A (ja) 2005-09-08
US20050182267A1 (en) 2005-08-18
SG114702A1 (en) 2005-09-28
KR100682697B1 (ko) 2007-02-15
PT1564203E (pt) 2010-01-15
BRPI0500395B8 (pt) 2021-05-25
MY143737A (en) 2011-07-04
JP4252040B2 (ja) 2009-04-08
WO2005077890A1 (fr) 2005-08-25
ATE452873T1 (de) 2010-01-15
AU2005200620B8 (en) 2011-06-02
CA2495960A1 (fr) 2005-08-13
MA27517A1 (fr) 2005-09-01
EP1564203A1 (fr) 2005-08-17
ES2338664T3 (es) 2010-05-11
DE602005018403D1 (de) 2010-02-04
AU2005200620A1 (en) 2005-09-01
CA2495960C (fr) 2007-11-27
AU2005200620B2 (en) 2011-05-19
NO20050740L (no) 2005-08-15
MY142270A (en) 2010-11-15
PL1564203T3 (pl) 2010-06-30
UA79479C2 (en) 2007-06-25
CN1680296A (zh) 2005-10-12
BRPI0500395B1 (pt) 2018-11-06
FR2866334A1 (fr) 2005-08-19
NO333488B1 (no) 2013-06-24
ZA200501256B (en) 2005-11-30
NO20050740D0 (no) 2005-02-11
HRP20100103T1 (hr) 2010-04-30
ME01806B (me) 2010-12-31
AU2005200620A8 (en) 2011-06-02
RS51212B (sr) 2010-12-31
FR2866334B1 (fr) 2006-05-26
US7999129B2 (en) 2011-08-16
KR20060041902A (ko) 2006-05-12
GEP20063961B (en) 2006-11-10
EA007789B1 (ru) 2007-02-27
MXPA05001634A (es) 2005-08-19
US7476751B2 (en) 2009-01-13
EP1564203B1 (fr) 2009-12-23
US20090131719A1 (en) 2009-05-21
SI1564203T1 (sl) 2010-03-31
NZ538192A (en) 2005-12-23
EA200500201A1 (ru) 2005-08-25
CN1315794C (zh) 2007-05-16
CY1109737T1 (el) 2014-09-10
AR047667A1 (es) 2006-02-01
DK1564203T3 (da) 2010-04-12
HK1079187A1 (en) 2006-03-31

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Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/11/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/02/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2866 DE 09-12-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.