BRPI0505586A - material substituto do osso contendo antibiótico/antibióticos com liberação de substáncia ativa de ação retardadora - Google Patents

material substituto do osso contendo antibiótico/antibióticos com liberação de substáncia ativa de ação retardadora

Info

Publication number
BRPI0505586A
BRPI0505586A BRPI0505586-5A BRPI0505586A BRPI0505586A BR PI0505586 A BRPI0505586 A BR PI0505586A BR PI0505586 A BRPI0505586 A BR PI0505586A BR PI0505586 A BRPI0505586 A BR PI0505586A
Authority
BR
Brazil
Prior art keywords
antibiotics
antibiotic
bone substitute
active substance
glycerine
Prior art date
Application number
BRPI0505586-5A
Other languages
English (en)
Inventor
Klaus-Dieter Kuehn
Sebastian Vogt
Original Assignee
Heraeus Kulzer Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heraeus Kulzer Gmbh filed Critical Heraeus Kulzer Gmbh
Publication of BRPI0505586A publication Critical patent/BRPI0505586A/pt
Publication of BRPI0505586B1 publication Critical patent/BRPI0505586B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"MATERIAL SUBSTITUTO DO OSSO CONTENDO ANTIBIóTICO/ANTIBIóTICOS COM LIBERAçãO DE SUBSTáNCIA ATIVA DE AçãO RETARDADORA". A presente invenção refere-se a um material substituto do osso contendo antibiótico/antibióticos, caracterizado pelo fato de ser formado de uma mistura condensada de grânulos do dihidrato de sulfato de cálcio, do carbonato de cálcio e de pelo menos um representante dos antibióticos aminoglicosídeo, dos antibióticos lincosamida, dos antibióticos glicopeptídeo, dos antibióticos macrolida, dos antíbióticos cetolida, dos nitroimidazóis, dos antibióticos fluorquinoiona e dos antibióticos oxazolidinona, dos antibióticos esteroidais, dos anti-sépticos e dos antibióticos fungicidas/fungistáticos, que são parcialmente ou completamente envolvidos com uma camada de tripalmitato de glicerina e/ou triestearato de glicerina e/ou trilaurato de glicerina e/ou álcool l-hexadecílico, a qual liga os grânulos uns com os outros.
BRPI0505586A 2004-12-15 2005-12-14 material substituto do osso contendo antibiótico, com liberação sustentada do dito antibiótico BRPI0505586B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004060666A DE102004060666B3 (de) 2004-12-15 2004-12-15 Antibiotikum/Antibiotika enthaltendes Knochenersatzmaterial mit retardierender Wirkstofffreisetzung

Publications (2)

Publication Number Publication Date
BRPI0505586A true BRPI0505586A (pt) 2006-09-12
BRPI0505586B1 BRPI0505586B1 (pt) 2018-05-08

Family

ID=36011910

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0505586A BRPI0505586B1 (pt) 2004-12-15 2005-12-14 material substituto do osso contendo antibiótico, com liberação sustentada do dito antibiótico

Country Status (15)

Country Link
US (1) US7923019B2 (pt)
EP (1) EP1671661B1 (pt)
JP (1) JP4523544B2 (pt)
CN (1) CN100571792C (pt)
AU (1) AU2005239648B2 (pt)
BR (1) BRPI0505586B1 (pt)
CA (1) CA2526954C (pt)
CY (1) CY1110514T1 (pt)
DE (2) DE102004060666B3 (pt)
DK (1) DK1671661T3 (pt)
ES (1) ES2330015T3 (pt)
PL (1) PL1671661T3 (pt)
PT (1) PT1671661E (pt)
SI (1) SI1671661T1 (pt)
ZA (1) ZA200510166B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006016598A1 (de) * 2006-04-06 2007-11-15 Heraeus Kulzer Gmbh Beschichtete Vaskulärimplantate
DE102006037362B3 (de) * 2006-08-09 2007-09-20 Heraeus Kulzer Gmbh Knochenersatzmaterial
WO2008141268A2 (en) * 2007-05-10 2008-11-20 Smith & Nephew, Inc. Enhancement of the calcium sensing receptor
EP2018864A1 (en) 2007-07-23 2009-01-28 Biomet Deutschland GmbH Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition
US8226766B2 (en) * 2010-12-22 2012-07-24 United States Gypsum Company Set accelerator for gypsum hydration
DE102011016277B4 (de) * 2011-04-06 2013-02-21 Heraeus Medical Gmbh Plastisch verformbares, biodegradierbares Hämostyptikum und Verfahren zum Formen eines solchen
DE102011122752B3 (de) * 2011-04-06 2013-02-21 Heraeus Medical Gmbh Medizinisches Implantat enthaltend ein plastisch verformbares,biodegradierbares Hämostyptikum
ES2393602B1 (es) 2011-06-09 2013-10-02 Universidad Complutense De Madrid Materiales biocerámicos para el tratamiento de la osteomielitis.
DE102012014419A1 (de) 2012-07-20 2014-01-23 Heraeus Medical Gmbh Pastenförmiges Knochenersatzmaterial
CN103143024B (zh) * 2013-02-22 2014-06-25 浙江省中医药研究院 一种植入型补肾健骨中药提取物-抗生素-硫酸钙缓释系统及其制备方法和应用
CN103446622B (zh) * 2013-08-13 2015-07-08 江苏大学 一种利用α-半水硫酸钙晶须释放钙及万古霉素的方法
DE102015100806A1 (de) 2015-01-20 2016-07-21 Antonis Alexakis Biokompatibles Formteil
EP4382109A1 (de) * 2022-12-06 2024-06-12 Heraeus Medical GmbH Anwendung eines kompositmaterials
AU2023255057B2 (en) * 2022-12-06 2025-03-13 Heraeus Medical Gmbh Use of a composite material

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376331A3 (en) * 1988-12-29 1991-03-13 Asahi Kogaku Kogyo Kabushiki Kaisha Slow release drug delivery granules and process for production thereof
US5149368A (en) * 1991-01-10 1992-09-22 Liu Sung Tsuen Resorbable bioactive calcium phosphate cement
US5681873A (en) * 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US5614206A (en) 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
US5756127A (en) 1996-10-29 1998-05-26 Wright Medical Technology, Inc. Implantable bioresorbable string of calcium sulfate beads
EP0985413A1 (de) * 1998-08-06 2000-03-15 Jörg Michael Dr. Dr. Schierholz Medizinprodukte mit retardierter pharmakologischer Aktivität und Verfahren zu ihrer Herstellung
US6224635B1 (en) * 1998-11-06 2001-05-01 Hospital For Joint Diseases Implantation of surgical implants with calcium sulfate
CA2360938C (en) 1999-02-02 2008-01-08 Warren Oliver Haggard Controlled release composite
US7371408B1 (en) 1999-06-07 2008-05-13 Wright Medical Technology, Inc. Bone graft substitute composition
DE19953771C1 (de) 1999-11-09 2001-06-13 Coripharm Medizinprodukte Gmbh Resorbierbares Knochen-Implantatmaterial sowie Verfahren zur Herstellung desselben
SE520688C2 (sv) * 2000-04-11 2003-08-12 Bone Support Ab Ett injicerbart ersättningsmaterial för benmineral
EP1153621A1 (de) * 2000-05-12 2001-11-14 MERCK PATENT GmbH Biozemente auf TCP-PHA-Basismischung mit verbesserter Kompressionsfestigkeit
DE10114245A1 (de) 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung
DE10114244A1 (de) 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung
DE10114364A1 (de) 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Verfahren zur Herstellung von antibiotischen Kompositen
DE60305036T2 (de) * 2002-06-19 2006-10-12 Dr. H.C. Robert Mathys Stiftung Hydraulischer zement auf basis von calciumphosphat für chirurgische anwendungen
DE10262176B4 (de) * 2002-06-21 2007-10-04 Heraeus Kulzer Gmbh Verfahren zur Herstellung von antibiotisch beschichteten porösen Körpern sowie Verwendung
DE10227938B4 (de) 2002-06-21 2006-07-20 Heraeus Kulzer Gmbh Pharmazeutische Zubereitung, Verfahren zu ihrer Herstellung sowie deren Verwendung
DE10227914A1 (de) * 2002-06-21 2004-01-15 Heraeus Kulzer Gmbh & Co. Kg Pharmazeutische Zubereitung mit retardierender Wirkstofffreisetzung, Verfahren zu ihrer Herstellung und Verwendung
US6652887B1 (en) 2002-06-24 2003-11-25 Wright Medical Technology, Inc. Bone graft substitute composition
US8029755B2 (en) * 2003-08-06 2011-10-04 Angstrom Medica Tricalcium phosphates, their composites, implants incorporating them, and method for their production

Also Published As

Publication number Publication date
JP4523544B2 (ja) 2010-08-11
CN1795934A (zh) 2006-07-05
AU2005239648A1 (en) 2006-06-29
US7923019B2 (en) 2011-04-12
CA2526954A1 (en) 2006-06-15
US20060127444A1 (en) 2006-06-15
AU2005239648B2 (en) 2007-08-16
CA2526954C (en) 2009-06-02
PL1671661T3 (pl) 2010-01-29
CY1110514T1 (el) 2015-04-29
PT1671661E (pt) 2009-10-22
EP1671661A3 (de) 2007-10-03
DE502005007699D1 (de) 2009-08-27
EP1671661B1 (de) 2009-07-15
BRPI0505586B1 (pt) 2018-05-08
SI1671661T1 (sl) 2010-01-29
JP2006167469A (ja) 2006-06-29
CN100571792C (zh) 2009-12-23
EP1671661A2 (de) 2006-06-21
DE102004060666B3 (de) 2006-03-30
DK1671661T3 (da) 2009-11-16
ES2330015T3 (es) 2009-12-03
ZA200510166B (en) 2006-11-29

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: HERAEUS MEDICAL GMBH (DE)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2609 DE 05-01-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.