BRPI0506790A - processos de preparação de uma cepa de microorganismos evoluìdos e de 1,2-propanodiol, e, cepa - Google Patents

processos de preparação de uma cepa de microorganismos evoluìdos e de 1,2-propanodiol, e, cepa

Info

Publication number
BRPI0506790A
BRPI0506790A BRPI0506790-1A BRPI0506790A BRPI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A
Authority
BR
Brazil
Prior art keywords
propanediol
microorganisms
evolved
strain
preparing
Prior art date
Application number
BRPI0506790-1A
Other languages
English (en)
Inventor
Isabelle Meynial-Salles
Benjamin Gonzalez
Philippe Soucaille
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of BRPI0506790A publication Critical patent/BRPI0506790A/pt
Publication of BRPI0506790B1 publication Critical patent/BRPI0506790B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/28—Acetone-containing products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"PROCESSOS DE PREPARAçãO DE UMA CEPA DE MICROORGANISMOS EVOLUìDOS E DE 1,2-PROPANODIOL, E, CEPA" A invenção refere-se a um novo processo de preparação de um cepa de microorganismos evoluídos para a produção de 1,2-propanodiol por metabolismo de uma fonte de carbono simples, o dito processo compreendendo a cultura sob pressão de seleção em um meio de cultura adequado que compreende uma fonte de carbono simples, de uma cepa bacteriana inicial compreendendo uma deleção do gene tpiA e uma deleção de ao menos um gene implicado na conversão do metil glioxal (propanal) em lactato, a fim de fazer evoluir na dita cepa inicial um mais genes implicados na via de biosíntese do DHAP em metilglioxal e depois em 1,2-propanodiol para os genes evoluídos que têm uma atividade <sym>1,2-propanodiol síntase<sym> melhorada, e depois seleciona-se e isola-se a ou as cepas de microorganismos evoluídos que têm uma atividade <sym>1,2 propanodiol síntase<sym> melhorada. A invenção refere-se igualmente aos microorganismos iniciais e os microorganismos eveoluidos assim obtidos e um processo de preparação de 1,2-propanodiol e eventualmente de acetona por cultura dos microorganismos evoluídos.
BRPI0506790-1A 2004-01-12 2005-01-12 processo de preparação de uma cepa de escherichia coli evoluída para a produção de 1,2-propanodiol por metabolismo de uma fonte de carbono simples e processo de preparação de 1,2-propanodiol BRPI0506790B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0400214A FR2864967B1 (fr) 2004-01-12 2004-01-12 Microorganisme evolue pour la production de 1,2-propanediol
FR0400214 2004-01-12
PCT/FR2005/000070 WO2005073364A2 (fr) 2004-01-12 2005-01-12 Microorganisme evolue pour la production de 1,2-propanediol

Publications (2)

Publication Number Publication Date
BRPI0506790A true BRPI0506790A (pt) 2007-05-22
BRPI0506790B1 BRPI0506790B1 (pt) 2020-12-22

Family

ID=34684930

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506790-1A BRPI0506790B1 (pt) 2004-01-12 2005-01-12 processo de preparação de uma cepa de escherichia coli evoluída para a produção de 1,2-propanodiol por metabolismo de uma fonte de carbono simples e processo de preparação de 1,2-propanodiol

Country Status (18)

Country Link
US (1) US8252579B2 (pt)
EP (2) EP2192180A1 (pt)
JP (1) JP4613177B2 (pt)
KR (1) KR101229525B1 (pt)
CN (1) CN1910278B (pt)
AT (1) ATE440135T1 (pt)
BR (1) BRPI0506790B1 (pt)
CA (1) CA2547695C (pt)
DE (1) DE602005016073D1 (pt)
DK (1) DK1704230T3 (pt)
ES (1) ES2329914T3 (pt)
FR (1) FR2864967B1 (pt)
PL (1) PL1704230T3 (pt)
PT (1) PT1704230E (pt)
RU (1) RU2407793C2 (pt)
SI (1) SI1704230T1 (pt)
WO (1) WO2005073364A2 (pt)
ZA (1) ZA200605440B (pt)

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EP2192180A1 (fr) 2010-06-02
ZA200605440B (en) 2007-04-25
KR20060123490A (ko) 2006-12-01
PT1704230E (pt) 2009-10-14
RU2006129295A (ru) 2008-02-20
WO2005073364A2 (fr) 2005-08-11
RU2407793C2 (ru) 2010-12-27
ATE440135T1 (de) 2009-09-15
CA2547695C (fr) 2015-03-10
FR2864967B1 (fr) 2006-05-19
CN1910278A (zh) 2007-02-07
SI1704230T1 (sl) 2009-12-31
JP4613177B2 (ja) 2011-01-12
US8252579B2 (en) 2012-08-28
WO2005073364A3 (fr) 2005-09-29
EP1704230A2 (fr) 2006-09-27
CN1910278B (zh) 2010-05-26
CA2547695A1 (fr) 2005-08-11
US20070072279A1 (en) 2007-03-29
FR2864967A1 (fr) 2005-07-15
JP2007517517A (ja) 2007-07-05
DE602005016073D1 (de) 2009-10-01
PL1704230T3 (pl) 2010-01-29
KR101229525B1 (ko) 2013-02-04
DK1704230T3 (da) 2009-11-02
EP1704230B1 (fr) 2009-08-19
BRPI0506790B1 (pt) 2020-12-22
ES2329914T3 (es) 2009-12-02

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