BRPI0506880A - derivados de acilaminotiazol, sua preparação e sua aplicação em terapêutica - Google Patents
derivados de acilaminotiazol, sua preparação e sua aplicação em terapêuticaInfo
- Publication number
- BRPI0506880A BRPI0506880A BRPI0506880-0A BRPI0506880A BRPI0506880A BR PI0506880 A BRPI0506880 A BR PI0506880A BR PI0506880 A BRPI0506880 A BR PI0506880A BR PI0506880 A BRPI0506880 A BR PI0506880A
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- group
- alkyl
- alkoxy
- cycloalkyl
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical compound C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 abstract 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
DERIVADOS DE ACILAMINOTIAZOL, SUA PREPARAçãO E SUA APLICAçãO EM TERAPêUTICA .A presente invenção refere-se a composto que responde à fórmula geral (l) na qual, R~ 1~ representa ou uma C~ 1~- 6~ alquila eventualmente substituída ou uma C~ 3~-7~ cicloalquila, um tiofeno, um benzotiofeno, uma piridinila, uma furanila ou uma fenila eventualmente substituída; R~ 2~ e R'~ 2~ representam independentemente um do outro um átomo de hidrogênio, um átomo de halogênio, um hidróxi, um C~1~-3~ alcóxi, uma C~1~-3~ alquila, uma C~3~-7~ cicloalquila, um grupo O-C(O)-C~1~-6~ alquila, ou R~ 2~ e R'~ 2~ formam juntos um grupo oxo; R~ 3~ representa um átomo de hidrogênio, uma C~ 1~-6~ alquila eventualmente substituída por um hidróxi, uma C~ 1~-6~ cicloaquila ou um C~ 1~-3~ alcóxi; um ou outro de R~ 4~ ou R~ 5~ representa um grupo Z e um ou outro de R~ 4~ ou R~ 5~ representa um grupo -C(X)R~ 6~ ; G representa uma ligação simples ou um grupo - CH~ 2~ -; Y representa uma ligação simples, um átomo de oxigênio, de enxofre, um grupo C~ 1~-4~ alquileno eventualmente substituído ou -N(W)-; A e B representam, independentemente um do outro, um átomo de hidrogênio, de halogênio, um grupo hidróxi, C~ 1~-3~ alquila, C~ 1~-3~ alcóxi, trifluormetila, trifluormetóxi ou -O-CHF~ 2~ ; X representa O ou S; R~6~ representa um grupo C~ 1~-6~ alcóxi eventualmente substituído, hidróxi ou -NR~ 7~ R~ 8~; R~ 7~ e R~ 8~ representam, independentemente um do outro : ou um átomo de hidrogênio; ou um grupo C~ 1~-6~ alquila, eventualmente substituído ou um grupo C~ 3~-7~ cicloalquila, eventualmente substituído,C~ 1~-6~ alcóxi ou fenila eventualmente substituído; ou R~ 7~ e R~ 8~ , com o átomo de nitrogênio que os porta, formam um ciclo aziridina, azetidina, pirrolidina, piperidina, morfolina ou benzopiperidina; no estado de base, de sal de adição a um ácido ou de hidrato. Aplicação em terapêutica.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0400387A FR2865206B1 (fr) | 2004-01-16 | 2004-01-16 | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| FR0408115A FR2873370B1 (fr) | 2004-07-22 | 2004-07-22 | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| PCT/FR2005/000032 WO2005073226A1 (fr) | 2004-01-16 | 2005-01-07 | Derives d’acylaminothiazole, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0506880A true BRPI0506880A (pt) | 2007-06-26 |
Family
ID=34828645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0506880-0A BRPI0506880A (pt) | 2004-01-16 | 2005-01-07 | derivados de acilaminotiazol, sua preparação e sua aplicação em terapêutica |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7582664B2 (pt) |
| EP (1) | EP1709041A1 (pt) |
| JP (1) | JP2007517840A (pt) |
| AR (1) | AR047387A1 (pt) |
| AU (1) | AU2005209442B2 (pt) |
| BR (1) | BRPI0506880A (pt) |
| CA (1) | CA2551142A1 (pt) |
| IL (1) | IL176701A (pt) |
| MA (1) | MA28233A1 (pt) |
| NO (1) | NO20063675L (pt) |
| NZ (1) | NZ548531A (pt) |
| RU (1) | RU2401262C2 (pt) |
| TW (1) | TWI340642B (pt) |
| WO (1) | WO2005073226A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007084391A2 (en) * | 2006-01-18 | 2007-07-26 | Amgen Inc. | Thiazole compounds as protein kinase b ( pkb) inhibitors |
| EP2173728A2 (en) | 2007-07-17 | 2010-04-14 | Amgen Inc. | Heterocyclic modulators of pkb |
| US7919504B2 (en) * | 2007-07-17 | 2011-04-05 | Amgen Inc. | Thiadiazole modulators of PKB |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9401034D0 (en) * | 1994-01-20 | 1994-03-16 | British Bio Technology | Metalloproteinase inhibitors |
| JP2001504498A (ja) * | 1996-11-22 | 2001-04-03 | エラン・ファーマシューティカルズ・インコーポレイテッド | Ｎ―（アリール／ヘテロアリール／アルキルアセチル）アミノ酸アミドおよびその医薬組成物、並びに該化合物を用いたβ―アミロイドペプチドの放出および／またはその合成を阻害する方法 |
| WO2000024392A1 (en) * | 1998-10-26 | 2000-05-04 | Sumitomo Pharmaceuticals Company, Limited | β-AMYLOID FORMATION INHIBITORS |
| US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| AR039059A1 (es) * | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
| FR2842523A1 (fr) * | 2002-07-17 | 2004-01-23 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| JP2006504796A (ja) * | 2002-10-09 | 2006-02-09 | ファイザー・プロダクツ・インク | 神経変性性障害を処置するためのチアゾール化合物 |
| PT1709018E (pt) * | 2004-01-16 | 2011-10-24 | Sanofi Sa | Derivados de acilaminotiazole e sua aplicação como inibidores |
-
2005
- 2005-01-07 AU AU2005209442A patent/AU2005209442B2/en not_active Ceased
- 2005-01-07 EP EP05717380A patent/EP1709041A1/fr not_active Withdrawn
- 2005-01-07 BR BRPI0506880-0A patent/BRPI0506880A/pt not_active IP Right Cessation
- 2005-01-07 CA CA002551142A patent/CA2551142A1/fr not_active Abandoned
- 2005-01-07 WO PCT/FR2005/000032 patent/WO2005073226A1/fr not_active Ceased
- 2005-01-07 JP JP2006548342A patent/JP2007517840A/ja not_active Ceased
- 2005-01-07 RU RU2006129642/04A patent/RU2401262C2/ru not_active IP Right Cessation
- 2005-01-07 NZ NZ548531A patent/NZ548531A/en unknown
- 2005-01-14 AR ARP050100129A patent/AR047387A1/es unknown
- 2005-01-14 TW TW094101173A patent/TWI340642B/zh not_active IP Right Cessation
-
2006
- 2006-06-19 MA MA29119A patent/MA28233A1/fr unknown
- 2006-07-04 IL IL176701A patent/IL176701A/en not_active IP Right Cessation
- 2006-07-07 US US11/456,123 patent/US7582664B2/en not_active Expired - Fee Related
- 2006-08-15 NO NO20063675A patent/NO20063675L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20060293365A1 (en) | 2006-12-28 |
| TW200533345A (en) | 2005-10-16 |
| WO2005073226A1 (fr) | 2005-08-11 |
| IL176701A0 (en) | 2006-10-31 |
| RU2006129642A (ru) | 2008-02-27 |
| CA2551142A1 (fr) | 2005-08-11 |
| RU2401262C2 (ru) | 2010-10-10 |
| NZ548531A (en) | 2010-01-29 |
| AU2005209442B2 (en) | 2011-03-31 |
| AR047387A1 (es) | 2006-01-18 |
| JP2007517840A (ja) | 2007-07-05 |
| EP1709041A1 (fr) | 2006-10-11 |
| TWI340642B (en) | 2011-04-21 |
| US7582664B2 (en) | 2009-09-01 |
| MA28233A1 (fr) | 2006-10-02 |
| IL176701A (en) | 2012-01-31 |
| NO20063675L (no) | 2006-10-16 |
| AU2005209442A1 (en) | 2005-08-11 |
| HK1104542A1 (en) | 2008-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DA 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2205 DE 09/04/2013. |