BRPI0507200A - sistema diagnóstico do tipo laboratório sobre chip integrado, aparelho e kit de ensaio para a análise de amostras biológicas e/ou ambientais, e, método para a fabricação de um sistema diagnóstico do tipo laboratório sobre chip integrado - Google Patents

sistema diagnóstico do tipo laboratório sobre chip integrado, aparelho e kit de ensaio para a análise de amostras biológicas e/ou ambientais, e, método para a fabricação de um sistema diagnóstico do tipo laboratório sobre chip integrado

Info

Publication number
BRPI0507200A
BRPI0507200A BRPI0507200-0A BRPI0507200A BRPI0507200A BR PI0507200 A BRPI0507200 A BR PI0507200A BR PI0507200 A BRPI0507200 A BR PI0507200A BR PI0507200 A BRPI0507200 A BR PI0507200A
Authority
BR
Brazil
Prior art keywords
fluid
integrated chip
laboratory
lysis
diagnostic system
Prior art date
Application number
BRPI0507200-0A
Other languages
English (en)
Inventor
Friedhelm Schonfeld
Frithjof Von Germar
Frank Karlsen
Jan Lichtenberg
Sabeth Verpoorte
Original Assignee
Norchip As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norchip As filed Critical Norchip As
Publication of BRPI0507200A publication Critical patent/BRPI0507200A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/049—Valves integrated in closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4005—Concentrating samples by transferring a selected component through a membrane
    • G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Electrochemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Stabilization Of Oscillater, Synchronisation, Frequency Synthesizers (AREA)

Abstract

"SISTEMA DIAGNóSTICO DO TIPO LABORATóRIO SOBRE CHIP INTEGRADO, APARELHO E KIT DE ENSAIO PARA A ANáLISE DE AMOSTRAS BIOLóGICAS E/OU AMBIENTAIS, E, MéTODO PARA A FABRICAçãO DE UM SISTEMA DIAGNóSTICO DO TIPO LABORATóRIO SOBRE CHIP INTEGRADO" Um sistema diagnóstico do tipo laboratório sobre chip integrado para efetuar um processo de preparação de amostra em uma amostra de fluido contendo células e/ou partículas, o sistema incluindo: (a) uma entrada para uma amostra de fluido; (b) uma unidade de lise para lise de células e/ou partículas contidas na amostra de fluido; (c) uma unidade de extração de ácido nucleico para extração de ácidos nucleico das células e/ou partículas contidas na amostra de fluido; (d) um reservatório contendo um fluido de lise; (e) um reservatório contendo um eluente para remover ácidos nucleicos colecionados na unidade de extração de ácido nucleico; em que a entrada de amostra está em comunicação fluida com a unidade de lise, uma válvula opcional estando presente para controlar o fluxo de fluido entre elas; em que a unidade de lise está em comunicação fluida com a unidade de extração de ácido nucleico, uma válvula opcional estando presente para controlar o fluxo de fluido entre elas; em que o reservatório contendo o fluido de lise está em comunicação fluida com a unidade de lise, uma válvula opcional estando presente para controlar o fluxo de fluido entre elas; e em que o reservatório contendo o eluente está em comunicação fluida com a unidade de extração de ácido nucleico, uma válvula opcional estando presente para controlar o fluxo de fluido entre elas.
BRPI0507200-0A 2004-01-28 2005-01-28 sistema diagnóstico do tipo laboratório sobre chip integrado, aparelho e kit de ensaio para a análise de amostras biológicas e/ou ambientais, e, método para a fabricação de um sistema diagnóstico do tipo laboratório sobre chip integrado BRPI0507200A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0401868A GB2416030B (en) 2004-01-28 2004-01-28 A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
PCT/GB2005/000308 WO2005073691A1 (en) 2004-01-28 2005-01-28 A diagnostic system for carrying out a nucleic acid sequence amplification and detection process

Publications (1)

Publication Number Publication Date
BRPI0507200A true BRPI0507200A (pt) 2007-06-12

Family

ID=31971613

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507200-0A BRPI0507200A (pt) 2004-01-28 2005-01-28 sistema diagnóstico do tipo laboratório sobre chip integrado, aparelho e kit de ensaio para a análise de amostras biológicas e/ou ambientais, e, método para a fabricação de um sistema diagnóstico do tipo laboratório sobre chip integrado

Country Status (18)

Country Link
US (1) US20080227185A1 (pt)
EP (1) EP1714134B1 (pt)
JP (1) JP4921177B2 (pt)
KR (1) KR20070027507A (pt)
CN (1) CN1973197B (pt)
AT (1) ATE465401T1 (pt)
AU (1) AU2005208085B8 (pt)
BR (1) BRPI0507200A (pt)
CA (1) CA2554452A1 (pt)
DE (1) DE602005020742D1 (pt)
EA (1) EA011753B1 (pt)
GB (1) GB2416030B (pt)
IL (1) IL177122A (pt)
MX (1) MXPA06008469A (pt)
NO (1) NO20063782L (pt)
NZ (1) NZ548801A (pt)
WO (1) WO2005073691A1 (pt)
ZA (1) ZA200606197B (pt)

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