BRPI0507574A - piridazinonas como antagonistas de alfa 4 integrinas - Google Patents

piridazinonas como antagonistas de alfa 4 integrinas

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Publication number
BRPI0507574A
BRPI0507574A BRPI0507574-2A BRPI0507574A BRPI0507574A BR PI0507574 A BRPI0507574 A BR PI0507574A BR PI0507574 A BRPI0507574 A BR PI0507574A BR PI0507574 A BRPI0507574 A BR PI0507574A
Authority
BR
Brazil
Prior art keywords
pyridazinones
alpha
integrin antagonists
compounds
integrin
Prior art date
Application number
BRPI0507574-2A
Other languages
English (en)
Inventor
Kent Barbay
Wei He
Yong Gong
Alexey B Dyatkin
Tamara A Miskowski
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0507574A publication Critical patent/BRPI0507574A/pt

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    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P19/00—Drugs for skeletal disorders
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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Abstract

PIRIDAZINONAS COMO ANTAGONISTA DE ALFA 4 INTEGRINAS. A presente invenção refere-se a alguns novos compostos de fómula (I): métodos para preparar estes compostos, composições, intermediários e derivados dos mesmos e para o tratamento de um distúrbio mediado por integrina.
BRPI0507574-2A 2004-02-10 2005-02-09 piridazinonas como antagonistas de alfa 4 integrinas BRPI0507574A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54337204P 2004-02-10 2004-02-10
PCT/US2005/004182 WO2005077915A1 (en) 2004-02-10 2005-02-09 Pyridazinones as antagonists of a4 integrins

Publications (1)

Publication Number Publication Date
BRPI0507574A true BRPI0507574A (pt) 2007-07-03

Family

ID=34860412

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507574-2A BRPI0507574A (pt) 2004-02-10 2005-02-09 piridazinonas como antagonistas de alfa 4 integrinas

Country Status (11)

Country Link
US (1) US20050192279A1 (pt)
EP (1) EP1720839A1 (pt)
JP (1) JP2007522225A (pt)
KR (1) KR20070004676A (pt)
CN (1) CN1938283A (pt)
AR (1) AR047538A1 (pt)
AU (1) AU2005212424A1 (pt)
BR (1) BRPI0507574A (pt)
CA (1) CA2555594A1 (pt)
MX (1) MXPA06009100A (pt)
WO (1) WO2005077915A1 (pt)

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WO2005077915A1 (en) 2005-08-25
MXPA06009100A (es) 2007-02-02
EP1720839A1 (en) 2006-11-15
AU2005212424A1 (en) 2005-08-25
KR20070004676A (ko) 2007-01-09
JP2007522225A (ja) 2007-08-09
US20050192279A1 (en) 2005-09-01
CA2555594A1 (en) 2005-08-25
AR047538A1 (es) 2006-01-25

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