BRPI0508790A - ácido carboxìlicos, uso de um ácido carboxìlico, composto farmacêutico, método de preparação de ácido carboxìlico e composto intermediário - Google Patents

ácido carboxìlicos, uso de um ácido carboxìlico, composto farmacêutico, método de preparação de ácido carboxìlico e composto intermediário

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Publication number
BRPI0508790A
BRPI0508790A BRPI0508790-2A BRPI0508790A BRPI0508790A BR PI0508790 A BRPI0508790 A BR PI0508790A BR PI0508790 A BRPI0508790 A BR PI0508790A BR PI0508790 A BRPI0508790 A BR PI0508790A
Authority
BR
Brazil
Prior art keywords
carboxylic acid
carboxylic
preparation
carboxylic acids
compound
Prior art date
Application number
BRPI0508790-2A
Other languages
English (en)
Inventor
Dominique Swinnen
Catherine Jorand-Lebrun
Patrick Gerber
Jerome Gonzalez
Agnes Bombrun
Original Assignee
Applied Research Systems
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Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BRPI0508790A publication Critical patent/BRPI0508790A/pt

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    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
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    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/31—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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  • Steroid Compounds (AREA)

Abstract

"áCIDO CARBOXìLICOS, USO DE UM áCIDO CARBOXìLICO, COMPOSTO FARMACêUTICO, MéTODO DE PREPARAçãO DE áCIDO CARBOXìLICO E COMPOSTO INTERMEDIáRIO", apresenta ácidos carboxílicos da Fórmula (I) e uso dos mesmos para o tratamento e/ou prevenção de obesidade e/ou transtornos metabólicos mediados por resistência à insulina ou hiperglicemia, compreendendo diabetes tipo I e/ou II, tolerância inadequada à glicose, resistência à insulina, hiperlipidemia, hipertrigliceridemia, hipercolesterolemia, síndrome doovário policístico (PCOS) Em especial, a presente invenção está relacionada com o uso de ácidos carboxílicos da Fórmula (I) para modular, articularmente, para inibir a atividade de PTPs.
BRPI0508790-2A 2004-04-07 2005-03-29 ácido carboxìlicos, uso de um ácido carboxìlico, composto farmacêutico, método de preparação de ácido carboxìlico e composto intermediário BRPI0508790A (pt)

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PCT/EP2005/051426 WO2005097773A1 (en) 2004-04-07 2005-03-29 1,1’-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b inhibitors

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CN118239851B (zh) * 2024-03-20 2025-07-25 蚌埠医科大学 一种ptpro抑制剂的制备方法及其应用

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CA2560648C (en) 2013-01-22
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AU2005231980B2 (en) 2011-09-08
HK1102597A1 (en) 2007-11-30
EA200601869A1 (ru) 2007-04-27
IL178425A0 (en) 2007-02-11
CN1997638B (zh) 2011-07-06
JP2007532514A (ja) 2007-11-15
AR048465A1 (es) 2006-04-26
EA011930B1 (ru) 2009-06-30
IL178425A (en) 2012-02-29
US7947851B2 (en) 2011-05-24
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US20090029903A1 (en) 2009-01-29
AU2005231980A1 (en) 2005-10-20
KR101194968B1 (ko) 2012-10-25
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MXPA06011678A (es) 2007-01-23
CN1997638A (zh) 2007-07-11

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