BRPI0508867A - processo para a preparação de compostos macrocìclicos - Google Patents

processo para a preparação de compostos macrocìclicos

Info

Publication number
BRPI0508867A
BRPI0508867A BRPI0508867-4A BRPI0508867A BRPI0508867A BR PI0508867 A BRPI0508867 A BR PI0508867A BR PI0508867 A BRPI0508867 A BR PI0508867A BR PI0508867 A BRPI0508867 A BR PI0508867A
Authority
BR
Brazil
Prior art keywords
preparation
macrocyclic compounds
formula
compounds
hcv
Prior art date
Application number
BRPI0508867-4A
Other languages
English (en)
Inventor
Carl Alan Busacca
Vittorio Farina
Fabrice Gallou
Nizar Haddad
Xiao-Jun Wang
Xudong Wei
Jinghua Xu
Yibo Xu
Nathan K Yee
Li Zhang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0508867A publication Critical patent/BRPI0508867A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE COMPOSTOS MACROCìCLICOS". A presente invenção refere-se a um processo de etapas múltiplas para a preparação de um composto macrocíclico da fórmula (I), no qual Q é um radical da seguinte fórmula (II) e as outras variaveis são como definidas aqui. Os compostos da fórmula (I) são agentes ativos potentes para o tratamnto de infecção pelo vírus da hepatite C (HVC).
BRPI0508867-4A 2004-03-15 2005-03-11 processo para a preparação de compostos macrocìclicos BRPI0508867A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55331704P 2004-03-15 2004-03-15
US57812304P 2004-06-08 2004-06-08
PCT/US2005/008366 WO2005090383A2 (en) 2004-03-15 2005-03-11 Process for preparing macrocyclic dipeptides which are suitable for the treatment of hepatitis c viral infections

Publications (1)

Publication Number Publication Date
BRPI0508867A true BRPI0508867A (pt) 2007-09-04

Family

ID=34962850

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508867-4A BRPI0508867A (pt) 2004-03-15 2005-03-11 processo para a preparação de compostos macrocìclicos

Country Status (14)

Country Link
US (2) US20050209135A1 (pt)
EP (1) EP1730166B1 (pt)
JP (1) JP4654239B2 (pt)
KR (1) KR20070009623A (pt)
AT (1) ATE459638T1 (pt)
AU (1) AU2005224092A1 (pt)
BR (1) BRPI0508867A (pt)
CA (1) CA2556917C (pt)
DE (1) DE602005019700D1 (pt)
ES (1) ES2338666T3 (pt)
IL (1) IL178080A0 (pt)
MX (1) MXPA06010389A (pt)
RU (1) RU2006136084A (pt)
WO (1) WO2005090383A2 (pt)

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Also Published As

Publication number Publication date
KR20070009623A (ko) 2007-01-18
RU2006136084A (ru) 2008-04-27
DE602005019700D1 (de) 2010-04-15
CA2556917A1 (en) 2005-09-29
IL178080A0 (en) 2006-12-31
EP1730166A2 (en) 2006-12-13
JP2007529529A (ja) 2007-10-25
US20080177029A1 (en) 2008-07-24
ES2338666T3 (es) 2010-05-11
US20050209135A1 (en) 2005-09-22
AU2005224092A1 (en) 2005-09-29
MXPA06010389A (es) 2007-01-19
ATE459638T1 (de) 2010-03-15
WO2005090383A2 (en) 2005-09-29
US7544798B2 (en) 2009-06-09
EP1730166B1 (en) 2010-03-03
WO2005090383A3 (en) 2005-12-01
CA2556917C (en) 2013-07-09
JP4654239B2 (ja) 2011-03-16

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.