BRPI0509588A - derivados e tetraidronaftiridina e um processo para preparação dos mesmos - Google Patents

derivados e tetraidronaftiridina e um processo para preparação dos mesmos

Info

Publication number
BRPI0509588A
BRPI0509588A BRPI0509588-3A BRPI0509588A BRPI0509588A BR PI0509588 A BRPI0509588 A BR PI0509588A BR PI0509588 A BRPI0509588 A BR PI0509588A BR PI0509588 A BRPI0509588 A BR PI0509588A
Authority
BR
Brazil
Prior art keywords
derivatives
tetrahydronaphthyridine
alkyl
optionally substituted
preparing same
Prior art date
Application number
BRPI0509588-3A
Other languages
English (en)
Inventor
Hitoshi Kubota
Yoshinori Nakamura
Takanori Higashijima
Yasuo Yamamoto
Kozo Oka
Shigeki Igarashi
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of BRPI0509588A publication Critical patent/BRPI0509588A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

DERIVADOS DE TETRAIDRONAFTIRIDINA E UM PROCESSO PARA PREPARAçãO DOS MESMOS. Um novo composto da fórmula (I): em que R¬ 1¬ é alcoxicarbonila ou similares; R¬ 2¬ é alquila ou similares; R¬ 3¬ é hidrogênio ou similares; R¬ 4¬ é alquileno ou similares; R¬ 5¬ é grupo heterocíclico opcionalmente substituído; R¬ 6¬, R¬ 7, e R¬ 8¬ são independentemente hidrogênio; alquila, alcóxi, ou similares; R¬ 10¬ é anel aromático opcionalmente substituído, ou similares; ou um sal farmaceuticamente aceitável deste, o qual tem uma atividade inibidora contra proteína de transferência de éster de colesterila (CETP).
BRPI0509588-3A 2004-04-02 2005-04-01 derivados e tetraidronaftiridina e um processo para preparação dos mesmos BRPI0509588A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004109551 2004-04-02
PCT/JP2005/006895 WO2005095395A2 (en) 2004-04-02 2005-04-01 Tetrahydronaphthyridine derivatives as cholesteryl ester transfer protein inhibitors

Publications (1)

Publication Number Publication Date
BRPI0509588A true BRPI0509588A (pt) 2007-09-25

Family

ID=35064445

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509588-3A BRPI0509588A (pt) 2004-04-02 2005-04-01 derivados e tetraidronaftiridina e um processo para preparação dos mesmos

Country Status (18)

Country Link
US (1) US7781443B2 (pt)
EP (1) EP1732924B1 (pt)
JP (1) JP4633731B2 (pt)
KR (1) KR100874623B1 (pt)
CN (1) CN100441579C (pt)
AR (1) AR048362A1 (pt)
AU (1) AU2005228291B2 (pt)
BR (1) BRPI0509588A (pt)
CA (1) CA2560008C (pt)
IL (1) IL178194A0 (pt)
MX (1) MXPA06011416A (pt)
MY (1) MY139887A (pt)
NO (1) NO20065012L (pt)
NZ (1) NZ550267A (pt)
RU (1) RU2356902C2 (pt)
TW (1) TWI345568B (pt)
WO (1) WO2005095395A2 (pt)
ZA (1) ZA200607782B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200601785A1 (ru) 2004-03-26 2007-02-27 Эли Лилли Энд Компани Соединения и способы лечения дислипидемии
WO2006069162A1 (en) 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
DK1848430T3 (da) 2004-12-31 2017-11-06 Dr Reddys Laboratories Ltd Nye benzylamin-derivativer som cetp-inhibitors
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
JP4681526B2 (ja) * 2005-09-29 2011-05-11 田辺三菱製薬株式会社 医薬組成物
RU2008119687A (ru) 2005-10-21 2009-11-27 Новартис АГ (CH) Комбинации органических соединений
US7652023B2 (en) 2005-11-23 2010-01-26 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7790770B2 (en) 2005-11-23 2010-09-07 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
UY30118A1 (es) * 2006-01-31 2007-06-29 Tanabe Seiyaku Co Compueto amina trisustituido
US7750019B2 (en) 2006-08-11 2010-07-06 Kowa Company, Ltd. Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same
US7790737B2 (en) 2007-03-13 2010-09-07 Kowa Company, Ltd. Substituted pyrimidine compounds and their utility as CETP inhibitors
MX2009010962A (es) 2007-04-13 2009-12-16 Kowa Co Compuesto pirimidina novedoso que tiene estructura de dibencilamina y medicamento que comprende el mismo.
AR069165A1 (es) * 2007-11-05 2010-01-06 Novartis Ag Derivados de 4-bencilamino-1-carboxacilpiperidina como inhibidores de cetp utiles para el tratamiento de hiperlipidemia
PT2404901E (pt) * 2007-12-03 2013-08-29 Novartis Ag Derivados de 4-benzilamino-pirrolidina 1,2-dissubstituídos como inibidores de cetp úteis para o tratamento de doenças tais como a hiperlipidemia ou a arteriosclerose
MX2011001887A (es) 2008-08-22 2011-04-04 Baxter Int Derivados de bencil carbonato polimericos.
CA2773038A1 (en) * 2009-09-04 2011-03-10 P. Jeffrey Conn Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
PL2604608T3 (pl) * 2009-11-27 2016-02-29 Adverio Pharma Gmbh Sposób wytwarzania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3-ylo]pirymidyn-5-ylo}metylokarbaminianu metylu
CN103415511B (zh) * 2011-01-31 2016-01-20 国立大学法人长崎大学 光学活性化合物或其盐的制造方法
CA2845284C (en) 2011-08-18 2018-03-06 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (cetp) inhibitors
JP6140168B2 (ja) 2011-09-27 2017-05-31 ドクター レディズ ラボラトリーズ リミテッド アテローム性動脈硬化症の処置のために有用なコレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての５−ベンジルアミノメチル−６−アミノピラゾロ［３，４−ｂ］ピリジン誘導体
WO2013103150A1 (ja) * 2012-01-06 2013-07-11 第一三共株式会社 置換ピリジン化合物の酸付加塩
CN104968345B (zh) 2012-01-19 2018-05-08 肿瘤疗法科学股份有限公司 1,5-萘啶衍生物和含1,5-萘啶衍生物的melk抑制剂
WO2014078778A2 (en) 2012-11-16 2014-05-22 Biocryst Pharmaceuticals, Inc. Antiviral azasugar-containing nucleosides
US20200077658A1 (en) 2016-12-16 2020-03-12 Basf Se Pesticidal Compounds
AU2018276192B2 (en) * 2017-05-30 2022-05-19 Dot Therapeutics-1, Inc. Method for producing optically active compound
CN107245074B (zh) * 2017-06-20 2019-04-09 牡丹江医学院附属红旗医院 用于治疗脑梗死的化合物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP970330B1 (en) * 1996-07-08 2004-06-30 Bayer Ag Cycloalkano pyridines
US6147090A (en) * 1998-09-17 2000-11-14 Pfizer Inc. 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6147089A (en) * 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
GT199900147A (es) * 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
PL371416A1 (en) 2002-02-01 2005-06-13 Pfizer Products Inc. Controlled release pharmaceutical dosage forms of a cholesteryl ester transfer protein inhibitor
EA200601785A1 (ru) * 2004-03-26 2007-02-27 Эли Лилли Энд Компани Соединения и способы лечения дислипидемии

Also Published As

Publication number Publication date
AU2005228291A1 (en) 2005-10-13
MY139887A (en) 2009-11-30
RU2006138597A (ru) 2008-05-10
WO2005095395A3 (en) 2006-06-01
US20070032485A1 (en) 2007-02-08
EP1732924A2 (en) 2006-12-20
ZA200607782B (en) 2008-02-27
CN100441579C (zh) 2008-12-10
RU2356902C2 (ru) 2009-05-27
NO20065012L (no) 2006-12-28
WO2005095395A2 (en) 2005-10-13
KR20060132966A (ko) 2006-12-22
EP1732924B1 (en) 2012-11-28
CA2560008A1 (en) 2005-10-13
AR048362A1 (es) 2006-04-19
NZ550267A (en) 2009-08-28
MXPA06011416A (es) 2006-12-20
CN1938301A (zh) 2007-03-28
CA2560008C (en) 2010-06-01
TW200536853A (en) 2005-11-16
KR100874623B1 (ko) 2008-12-17
IL178194A0 (en) 2006-12-31
US7781443B2 (en) 2010-08-24
JP4633731B2 (ja) 2011-02-16
JP2007530444A (ja) 2007-11-01
AU2005228291B2 (en) 2008-06-26
TWI345568B (en) 2011-07-21

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: MITSUBISHI TANABE PHARMA CORPORATION (JP)

Free format text: ALTERADO DE: TANABE SEIYAKU CO., LTD.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2204 DE 02/04/2013.