BRPI0510206A - método de identificação de fenótipo, célula isolada, métodos de identificação de agentes, agentes, agentes terapêuticos, método de avaliação de agente terapêutico, composição farmacêutica, métodos de tratamento, prevenção ou melhoria de disfunções e métodos de modulação - Google Patents

método de identificação de fenótipo, célula isolada, métodos de identificação de agentes, agentes, agentes terapêuticos, método de avaliação de agente terapêutico, composição farmacêutica, métodos de tratamento, prevenção ou melhoria de disfunções e métodos de modulação

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Publication number
BRPI0510206A
BRPI0510206A BRPI0510206-5A BRPI0510206A BRPI0510206A BR PI0510206 A BRPI0510206 A BR PI0510206A BR PI0510206 A BRPI0510206 A BR PI0510206A BR PI0510206 A BRPI0510206 A BR PI0510206A
Authority
BR
Brazil
Prior art keywords
methods
agents
dysfunctions
identification
therapeutic
Prior art date
Application number
BRPI0510206-5A
Other languages
English (en)
Inventor
Jane Brennan
Frederic Desauvage
Joel Edwards
Ellen Filvaroff
Iqbal Grewal
Wenhu Huang
Bryan Irving
Jagath Reddy Junutula
Daniel J Kirchhofer
Bobby Joe Payne
Franklin Peale Jr
Heidi Phillips
Ni Nancy Qian
Zheng-Zheng Shi
Mary Jean Sparks
Joy Stala
Tracy Tzu-Ling Tang
Peter Vogel
Dineli Wickramasinghe
Weilan Ye
Original Assignee
Genentech Inc
Lexicon Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Genentech Inc, Lexicon Genetics Inc filed Critical Genentech Inc
Publication of BRPI0510206A publication Critical patent/BRPI0510206A/pt

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Abstract

MéTODO DE IDENTIFICAçãO DE FENóTIPO, CéLULA ISOLADA, MéTODOS DE IDENTIFICAçãO DE AGENTES, AGENTES, AGENTES TERAPêUTICOS, MéTODO DE AVALIAçãO DE AGENTE TERAPêUTICO, COMPOSIçãO FARMACêUTICA, MéTODOS DE TRATAMENTO, MODULAçãO. A presente invenção refere-se a animais transgênicos, bem como composições e métodos relativos à caracterização da função genética. Específicamente, a presente invenção fornece camundongos transgênicos que compreendem rompimentos nos genes PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 ou PRO1480. Esses estudos e caracterizações in vivo podem fornecer identificação e descoberta valiosas de produtos terapêuticos e/ou tratamentos úteis na prevenção, melhoria ou correção de doenças ou disfunções associadas a rompimentos genéticos, tais como disfunções neurológicas; disfunções cardiovasculares, endoteliais ou angiogênicas; anormalidades dos olhos; disfunções imunológicas; disfunções oncológicas; disfunções ou anormalidades metabólicas dos ossos; disfunções metabólicas em lipídios; ou anormalidades do desenvolvimento.
BRPI0510206-5A 2004-05-12 2005-04-12 método de identificação de fenótipo, célula isolada, métodos de identificação de agentes, agentes, agentes terapêuticos, método de avaliação de agente terapêutico, composição farmacêutica, métodos de tratamento, prevenção ou melhoria de disfunções e métodos de modulação BRPI0510206A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57134704P 2004-05-12 2004-05-12
PCT/US2005/012478 WO2005112619A2 (en) 2004-05-12 2005-04-12 Novel gene disruptions, compositions and methods relating thereto

Publications (1)

Publication Number Publication Date
BRPI0510206A true BRPI0510206A (pt) 2007-10-16

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ID=35159700

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BRPI0510206-5A BRPI0510206A (pt) 2004-05-12 2005-04-12 método de identificação de fenótipo, célula isolada, métodos de identificação de agentes, agentes, agentes terapêuticos, método de avaliação de agente terapêutico, composição farmacêutica, métodos de tratamento, prevenção ou melhoria de disfunções e métodos de modulação

Country Status (8)

Country Link
US (1) US20080305106A1 (pt)
EP (1) EP1744620A2 (pt)
JP (1) JP2007536931A (pt)
AU (1) AU2005244742A1 (pt)
BR (1) BRPI0510206A (pt)
CA (1) CA2562482A1 (pt)
WO (1) WO2005112619A2 (pt)
ZA (1) ZA200608527B (pt)

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CN102281872A (zh) 2008-11-24 2011-12-14 西北大学 多价rna纳米颗粒组合物
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
CN102449170A (zh) * 2009-04-15 2012-05-09 西北大学 寡核苷酸功能化的纳米颗粒的递送
KR20120136345A (ko) 2009-10-30 2012-12-18 노오쓰웨스턴 유니버시티 주형화된 나노컨쥬게이트
WO2013033513A1 (en) 2011-08-31 2013-03-07 University Of Georgia Research Foundation, Inc. Apoptosis-targeting nanoparticles
ES2856091T3 (es) 2011-09-14 2021-09-27 Univ Northwestern Nanoconjugados capaces de atravesar la barrera hematoencefálica
JP6356614B2 (ja) 2012-02-17 2018-07-11 ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド 薬剤のミトコンドリア輸送のためのナノ粒子
WO2015013673A1 (en) 2013-07-25 2015-01-29 Aurasense Therapeutics, Llc Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
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US11213593B2 (en) 2014-11-21 2022-01-04 Northwestern University Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
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ZA200608527B (en) 2007-12-27
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