BRPI0510527A - método de estabilização de proteìnas - Google Patents

método de estabilização de proteìnas

Info

Publication number
BRPI0510527A
BRPI0510527A BRPI0510527-7A BRPI0510527A BRPI0510527A BR PI0510527 A BRPI0510527 A BR PI0510527A BR PI0510527 A BRPI0510527 A BR PI0510527A BR PI0510527 A BRPI0510527 A BR PI0510527A
Authority
BR
Brazil
Prior art keywords
bulk
stabilization method
monomeric protein
protein stabilization
excipient
Prior art date
Application number
BRPI0510527-7A
Other languages
English (en)
Inventor
Amer Jaber
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of BRPI0510527A publication Critical patent/BRPI0510527A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

MéTODO DE ESTABILIZAçãO DE PROTEìNAS. Um método de preparar uma solução a granel estabilizada de uma proteína monomérica é descrito, que consiste em fornecer um a granel de uma proteína monomérica em uma solução tampão e adicionar um excipiente ao a granel, em que o excipiente é selecionado a partir do grupo que consiste em agentes bacteriostáticos, tensoativos, agentes de isotonicidade, aminoácidos, antioxidantes e combinações dos mesmos. Preferivelmente a proteína monomérica é IFN-beta.
BRPI0510527-7A 2004-06-01 2005-05-27 método de estabilização de proteìnas BRPI0510527A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04076627 2004-06-01
PCT/EP2005/052413 WO2005117948A1 (en) 2004-06-01 2005-05-27 Method of stabilizing proteins

Publications (1)

Publication Number Publication Date
BRPI0510527A true BRPI0510527A (pt) 2007-10-30

Family

ID=34928262

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510527-7A BRPI0510527A (pt) 2004-06-01 2005-05-27 método de estabilização de proteìnas

Country Status (16)

Country Link
US (1) US7858082B2 (pt)
EP (1) EP1750750B1 (pt)
JP (1) JP2008500995A (pt)
CN (1) CN1993138B (pt)
AT (1) ATE543506T1 (pt)
AU (1) AU2005249232B2 (pt)
BR (1) BRPI0510527A (pt)
CA (1) CA2567309A1 (pt)
EA (1) EA012281B1 (pt)
ES (1) ES2381674T3 (pt)
IL (1) IL179617A0 (pt)
MX (1) MXPA06014079A (pt)
NO (1) NO20065861L (pt)
UA (1) UA93349C2 (pt)
WO (1) WO2005117948A1 (pt)
ZA (1) ZA200610041B (pt)

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Also Published As

Publication number Publication date
ZA200610041B (en) 2008-07-30
US20070244299A1 (en) 2007-10-18
AU2005249232B2 (en) 2010-08-05
EA012281B1 (ru) 2009-08-28
IL179617A0 (en) 2007-05-15
UA93349C2 (ru) 2011-02-10
EA200602254A1 (ru) 2007-06-29
AU2005249232A1 (en) 2005-12-15
US7858082B2 (en) 2010-12-28
JP2008500995A (ja) 2008-01-17
MXPA06014079A (es) 2007-02-15
CN1993138B (zh) 2010-12-15
CA2567309A1 (en) 2005-12-15
HK1102561A1 (en) 2007-11-30
WO2005117948A1 (en) 2005-12-15
EP1750750B1 (en) 2012-02-01
ATE543506T1 (de) 2012-02-15
ES2381674T3 (es) 2012-05-30
CN1993138A (zh) 2007-07-04
EP1750750A1 (en) 2007-02-14
NO20065861L (no) 2007-03-01

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2257 DE 08/04/2014.