BRPI0510639A - composto ou um sal ou uma pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de tratar ou prevenir distúrbios, de terapia de reposição hormonal, de abaixar nìveis de colesterol, triglicerìdeos ou ldl, de tratar cognição prejudicada ou prover neuroproteção, de prevenir concepção, de modular ou agonizar especificamente um ou mais receptores de estrogênio e, uso de um composto - Google Patents

composto ou um sal ou uma pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de tratar ou prevenir distúrbios, de terapia de reposição hormonal, de abaixar nìveis de colesterol, triglicerìdeos ou ldl, de tratar cognição prejudicada ou prover neuroproteção, de prevenir concepção, de modular ou agonizar especificamente um ou mais receptores de estrogênio e, uso de um composto

Info

Publication number
BRPI0510639A
BRPI0510639A BRPI0510639-7A BRPI0510639A BRPI0510639A BR PI0510639 A BRPI0510639 A BR PI0510639A BR PI0510639 A BRPI0510639 A BR PI0510639A BR PI0510639 A BRPI0510639 A BR PI0510639A
Authority
BR
Brazil
Prior art keywords
treating
preventing
methods
compound
estrogen receptors
Prior art date
Application number
BRPI0510639-7A
Other languages
English (en)
Inventor
Roger Olsson
Lene Hyldtoft
Fabrice Piu
Magnus Gustafsson
Original Assignee
Acadia Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acadia Pharm Inc filed Critical Acadia Pharm Inc
Publication of BRPI0510639A publication Critical patent/BRPI0510639A/pt

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    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

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Abstract

COMPOSTO OU UM SAL OU UMA PRó-DROGA FARMACEUTICAMENTE ACEITáVEL DO MESMO, COMPOSIçãO FARMACêUTICA, MéTODOS DE TRATAR OU PREVENIR DISTúRBIOS, DE TERAPIA DE REPOSIçãO HORMONAL, DE ABAIXAR NìVEIS DE COLESTEROL, TRIGLICERìDEOS OU LDL, DE TRATAR COGNIçãO PREJUDICADA OU PROVER NEUROPROTEçãO, DE PREVENIR CONCEPçãO, DE MODULAR OU AGONIZAR ESPECIFICAMENTE UM OU MAIS RECEPTORES DE ESTROGêNIO E, USO DE UM COMPOSTO São aqui descritas novos compostos difenílicos e métodos para usar vários compostos difenílicos para tratamento de doenças e distúrbios associados com receptores de estrogênio.
BRPI0510639-7A 2004-05-04 2005-05-03 composto ou um sal ou uma pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de tratar ou prevenir distúrbios, de terapia de reposição hormonal, de abaixar nìveis de colesterol, triglicerìdeos ou ldl, de tratar cognição prejudicada ou prover neuroproteção, de prevenir concepção, de modular ou agonizar especificamente um ou mais receptores de estrogênio e, uso de um composto BRPI0510639A (pt)

Applications Claiming Priority (2)

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US56833204P 2004-05-04 2004-05-04
PCT/US2005/015221 WO2005108337A2 (en) 2004-05-04 2005-05-03 Compounds with activity at estrogen receptor

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BRPI0510639A true BRPI0510639A (pt) 2007-11-13

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US (1) US20050256210A1 (pt)
EP (1) EP1747182A2 (pt)
JP (1) JP2007536238A (pt)
KR (1) KR20070028400A (pt)
CN (1) CN1997618A (pt)
AU (1) AU2005240609A1 (pt)
BR (1) BRPI0510639A (pt)
CA (1) CA2565094A1 (pt)
MX (1) MXPA06012705A (pt)
RU (1) RU2006142683A (pt)
WO (1) WO2005108337A2 (pt)
ZA (1) ZA200609870B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7825265B2 (en) * 2004-05-04 2010-11-02 Acadia Pharmaceuticals Inc. Compounds with activity at estrogen receptors
NL2000351C2 (nl) 2005-12-22 2007-09-11 Pfizer Prod Inc Estrogeen-modulatoren.
WO2008033894A2 (en) * 2006-09-14 2008-03-20 Acadia Pharmaceuticals Inc. Compounds with activity at estrogen receptors
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
KR101638035B1 (ko) 2007-01-22 2016-07-11 지티엑스, 인코포레이티드 핵 수용체에 결합하는 물질
MX2009008121A (es) * 2007-01-31 2009-08-12 Wyeth Corp Uso de ligados selectivos de receptores de estrogeno beta para tratar lesiones de pulmon agudas.
CN101835770B (zh) * 2007-10-26 2013-10-30 阿卡迪亚医药公司 在雌激素受体上具有活性的化合物
EP2554532A1 (en) * 2011-08-01 2013-02-06 Acadia Pharmaceuticals Inc. Diphenyl substituted cyclohexane derivatives, useful as modulators of the estrogen receptors beta
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
WO2014125121A1 (en) 2013-02-18 2014-08-21 Acadia Pharmaceuticals Inc. Compounds and compositions for treating neurodegenerative diseases

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2342294A (en) * 1940-03-13 1944-02-22 Joseph B Niederl Double salicylic acid type compound and method of preparing same
US3517071A (en) * 1963-07-01 1970-06-23 Eastman Kodak Co Three-dimensional polycyclic bisphenol polycarbonates and polyesters
CH586189A5 (pt) * 1970-01-28 1977-03-31 Bayer Ag
JPS575214B2 (pt) * 1972-06-01 1982-01-29
JPS4931651A (pt) * 1972-07-20 1974-03-22
US3872105A (en) * 1973-06-11 1975-03-18 Merrell Inc Richard Derivatives of 1,3-benzodioxole-2-carboxylic acid
US4201878A (en) * 1978-02-10 1980-05-06 General Electric Company Process for producing bisphenols
US4247484A (en) * 1979-09-20 1981-01-27 General Electric Company Keto-diphenol compounds
US4554309A (en) * 1982-12-27 1985-11-19 General Electric Company Polycarbonate from cycloalkylidene tetra alkyl substituted diphenol
US5962731A (en) * 1992-04-22 1999-10-05 Ligand Pharmaceuticals Incorporated Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US5283374A (en) * 1993-04-05 1994-02-01 Ocg Microelectronic Materials, Inc. Selected phenolic derivatives of 4-(4-hydroxyphenyl)-cyclohexanone and their use as sensitivity enhancers for radiation sensitive mixtures
US5691351A (en) * 1996-02-06 1997-11-25 Abbott Laboratories Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis
JP2000072695A (ja) * 1998-08-24 2000-03-07 Sumitomo Pharmaceut Co Ltd 環状化合物
US6218430B1 (en) * 1998-08-24 2001-04-17 Ligand Pharmaceuticals Incorporated Vitamin D3 mimics
JP3774789B2 (ja) * 1998-10-20 2006-05-17 本州化学工業株式会社 ３，３，５−トリメチルシクロヘキシリデンビスフェノール類の製造方法
HUP0202936A3 (en) * 1999-08-10 2003-11-28 Smithkline Beecham Corp 1,4-substituted 4,4-diaryl cyclohexanes, pharmaceutical compositions containing them and their use
US6255439B1 (en) * 2000-08-31 2001-07-03 General Electric Company 1,1-Bis(4-hydroxyphenyl)-3-alkylcyclohexanes, method for their preparation and polycarbonates prepared therefrom
WO2002018334A2 (en) * 2000-08-31 2002-03-07 Theravance, Inc. Sodium channel modulators
US7825265B2 (en) * 2004-05-04 2010-11-02 Acadia Pharmaceuticals Inc. Compounds with activity at estrogen receptors

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AU2005240609A1 (en) 2005-11-17
EP1747182A2 (en) 2007-01-31
RU2006142683A (ru) 2008-06-10
KR20070028400A (ko) 2007-03-12
CA2565094A1 (en) 2005-11-17
WO2005108337A2 (en) 2005-11-17
WO2005108337A3 (en) 2005-12-22
ZA200609870B (en) 2009-12-30
CN1997618A (zh) 2007-07-11
MXPA06012705A (es) 2007-03-26
US20050256210A1 (en) 2005-11-17
JP2007536238A (ja) 2007-12-13

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