BRPI0510981A - pirrol-2,5-dionas substituìdas como inibidores de proteìna quinase c - Google Patents

pirrol-2,5-dionas substituìdas como inibidores de proteìna quinase c

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Publication number
BRPI0510981A
BRPI0510981A BRPI0510981-7A BRPI0510981A BRPI0510981A BR PI0510981 A BRPI0510981 A BR PI0510981A BR PI0510981 A BRPI0510981 A BR PI0510981A BR PI0510981 A BRPI0510981 A BR PI0510981A
Authority
BR
Brazil
Prior art keywords
protein kinase
inhibitors
pyrrol
diones substituted
diones
Prior art date
Application number
BRPI0510981-7A
Other languages
English (en)
Inventor
Maurice Van Eis
Juergen Wagner
Peter Von Matt
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0510981A publication Critical patent/BRPI0510981A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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  • Health & Medical Sciences (AREA)
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Abstract

PIRROL-2,5-DIONAS SUBSTITUìDAS COMO INIBIDORES DE PROTEìNA QUINASE C A presente invenção refere-se a um composto da fórmula (I) onde R, R~ a~ e R~ b~ são como definidos na especificação, processos para sua produção, seu uso, em particular em transplantação, e composições farmacêuticas contendo-o.
BRPI0510981-7A 2004-05-13 2005-05-12 pirrol-2,5-dionas substituìdas como inibidores de proteìna quinase c BRPI0510981A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0410713.2A GB0410713D0 (en) 2004-05-13 2004-05-13 Organic compounds
PCT/EP2005/005183 WO2005113545A1 (en) 2004-05-13 2005-05-12 Substituted pyrrole-2, 5-diones as protein kinase c inhibitors

Publications (1)

Publication Number Publication Date
BRPI0510981A true BRPI0510981A (pt) 2007-12-04

Family

ID=32526998

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510981-7A BRPI0510981A (pt) 2004-05-13 2005-05-12 pirrol-2,5-dionas substituìdas como inibidores de proteìna quinase c

Country Status (13)

Country Link
US (1) US7851475B2 (pt)
EP (1) EP1747216B1 (pt)
JP (1) JP4549387B2 (pt)
KR (1) KR100919913B1 (pt)
CN (1) CN1950360B (pt)
AU (1) AU2005245561B2 (pt)
BR (1) BRPI0510981A (pt)
CA (1) CA2562027A1 (pt)
ES (1) ES2451165T3 (pt)
GB (1) GB0410713D0 (pt)
MX (1) MXPA06013080A (pt)
RU (1) RU2006143844A (pt)
WO (1) WO2005113545A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110152243A1 (en) * 2009-12-23 2011-06-23 Abbott Laboratories Novel thienopyrrole compounds
WO2018150430A1 (en) * 2017-02-19 2018-08-23 The National Institute for Biotechnology in the Negev Ltd. Peptide kinase inhibitors and methods of use thereof
CN110551103B (zh) * 2018-05-30 2022-08-23 北京大学深圳研究生院 一种jak3选择性抑制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645970B2 (en) * 2000-11-07 2003-11-11 Novartis Ag Indolylmaleimide derivatives
AU2002221810B2 (en) * 2000-11-07 2005-06-23 Novartis Ag Indolylmaleimide derivatives as protein kinase C inhibitors
PE20040079A1 (es) 2002-04-03 2004-04-19 Novartis Ag Derivados de indolilmaleimida

Also Published As

Publication number Publication date
JP2007536330A (ja) 2007-12-13
CN1950360A (zh) 2007-04-18
GB0410713D0 (en) 2004-06-16
JP4549387B2 (ja) 2010-09-22
CN1950360B (zh) 2011-07-20
RU2006143844A (ru) 2008-06-20
MXPA06013080A (es) 2007-02-28
US7851475B2 (en) 2010-12-14
EP1747216B1 (en) 2014-01-08
AU2005245561B2 (en) 2009-01-15
KR20070012475A (ko) 2007-01-25
ES2451165T3 (es) 2014-03-26
KR100919913B1 (ko) 2009-10-06
CA2562027A1 (en) 2005-12-01
EP1747216A1 (en) 2007-01-31
WO2005113545A1 (en) 2005-12-01
US20090221605A1 (en) 2009-09-03
AU2005245561A1 (en) 2005-12-01

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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