BRPI0511132A - derivados de pirimidina e composição farmacêutica compreendendo os mesmos - Google Patents

derivados de pirimidina e composição farmacêutica compreendendo os mesmos

Info

Publication number
BRPI0511132A
BRPI0511132A BRPI0511132-3A BRPI0511132A BRPI0511132A BR PI0511132 A BRPI0511132 A BR PI0511132A BR PI0511132 A BRPI0511132 A BR PI0511132A BR PI0511132 A BRPI0511132 A BR PI0511132A
Authority
BR
Brazil
Prior art keywords
pyrimidine derivatives
pharmaceutical composition
same
mammals
compounds
Prior art date
Application number
BRPI0511132-3A
Other languages
English (en)
Inventor
John Charles Kath
Michael Joseph Luzzio
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0511132A publication Critical patent/BRPI0511132A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE PIRIMIDINA E COMPOSIçãO FARMACêUTICA COMPREENDENDO OS MESMOS. A presente invenção refere-se a um composto da fórmula 1 em que A e Ar são como definidos aqui. Tais derivados de pirimidina novos são utilizáveis no tratamento de crescimento anormal de células, como câncer, em mamíferos. Esta invenção também refere-se a um método de uso de tais compostos no tratamento de crescimento anormal de células em mamíferos, especialmente seres humanos, e a composições farmacêuticas contendo estes compostos.
BRPI0511132-3A 2004-05-14 2005-05-02 derivados de pirimidina e composição farmacêutica compreendendo os mesmos BRPI0511132A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57121004P 2004-05-14 2004-05-14
PCT/IB2005/001239 WO2005111024A1 (en) 2004-05-14 2005-05-02 Pyrimidine derivatives for the treatment of abnormal cell growth

Publications (1)

Publication Number Publication Date
BRPI0511132A true BRPI0511132A (pt) 2007-11-27

Family

ID=34967615

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511132-3A BRPI0511132A (pt) 2004-05-14 2005-05-02 derivados de pirimidina e composição farmacêutica compreendendo os mesmos

Country Status (10)

Country Link
US (1) US7208499B2 (pt)
EP (1) EP1756090A1 (pt)
JP (1) JP2007537235A (pt)
AR (1) AR049170A1 (pt)
BR (1) BRPI0511132A (pt)
CA (1) CA2566477A1 (pt)
HN (1) HN2005000212A (pt)
MX (1) MXPA06011658A (pt)
TW (1) TW200607801A (pt)
WO (1) WO2005111024A1 (pt)

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Also Published As

Publication number Publication date
JP2007537235A (ja) 2007-12-20
US20050256144A1 (en) 2005-11-17
CA2566477A1 (en) 2005-11-24
US7208499B2 (en) 2007-04-24
TW200607801A (en) 2006-03-01
HN2005000212A (es) 2009-06-01
MXPA06011658A (es) 2006-12-14
AR049170A1 (es) 2006-07-05
WO2005111024A1 (en) 2005-11-24
EP1756090A1 (en) 2007-02-28

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.