BRPI0511267A - 1,5-diidropirido[3,2-b]indol-2-onas 4-substituìdas - Google Patents
1,5-diidropirido[3,2-b]indol-2-onas 4-substituìdasInfo
- Publication number
- BRPI0511267A BRPI0511267A BRPI0511267-2A BRPI0511267A BRPI0511267A BR PI0511267 A BRPI0511267 A BR PI0511267A BR PI0511267 A BRPI0511267 A BR PI0511267A BR PI0511267 A BRPI0511267 A BR PI0511267A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- alkyl
- indol
- ones
- amino
- Prior art date
Links
- -1 4-substituted 1,5-dihydropyrido [3,2-b] indol-2-ones Chemical class 0.000 title abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 150000005625 indol-2-ones Chemical class 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1,5-DIIDROPIRIDO¢3,2-b!INDOL-2-ONAS 4-SUBSTITUìDAS. A presente invenção refere-se a 1 ,5-diidropirido¢3,2-b!indol-2-onas 4-substituídas de fórmula (I): os N-óxidos, sais, formas estereoisoméricas, misturas racêmicas, pró-fármacos, ésteres e seus metabolitos, em que n é 1, 2 ou 3; R¬ 1¬ é hidrogênio, ciano, halo, carbonila substituída, metanimidamidila, N-hidroximetanimidamidila, mono- ou di(alquila C~ 1~-~ 4~)meta-nimidamidila, Het~ 1~ ou Het~ 2~; X é NR~ 2~, O, S, SO, SO~ 2~; R¬ 2¬ é hidrogênio, alquila C~ 1~-~ 10~. alquenila C~ 2~-~ 10~, cicloalquila C~ 3-~ 7~, os quais são opcionalmente substituídos; R¬ 2¬ é arila substituída por -COOR¬ 4¬; ou R¬ 2¬ é: (b-1); (b-2); -C~ p~H~ 2p~-CH(OR¬ 14¬)-C~ q~H~ 2q~-R¬ 15¬ (b-3); -CH~ 2~-CH~ 2~-(O-CH~ 2~-CH~ 2~)m-OR¬ 14¬ (b-4); -CH~- 2~CH~ 2~-(OCH~ 2~-CH~ 2~)m-NR¬ 5a¬R¬ 5b¬ (b-5); -a¬ 1¬ =a¬ 2¬ -a¬ 3¬ =a¬ 4¬ - e -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-N=CH-; -CH=CH-CH=N-; em que os átomos de hidrogênio em (c-1) - (c-5) podem ser substituídos por certos radicais; R¬ 3¬ é fenila opcionalmente substituída ou um sistema de anel heterocíclico aromático monocíclico ou bicíclico que pode ser substituído; R¬ 21¬ é halo, hidróxi, amino, carboxila, alquila C~ 1~-~ 6~, cicloalquila C~ 3~-~ 7~, arilalquila C~ 1~-~ 6~,formila, alquilcarbonila C~ 1~-~ 6~, alquiloxicarbonila C~ 1~-~ 6~, alquilcarbonila xy C~ 1~-~ 6~,-C(=O)-NR¬ 13¬R¬ 14¬; alquilóxi C~ 1~-~ 6~, arilalquilóxi C~ -~ 16~, polialoalquilóxi C~ 1~-~ 6, amino, mono ou di(alquila C~ 1~-~ 6~)amino, fomilamino, alquilcarbonilamino C~ 1~-~ 6~, alquil-sulfonilamino C~ 1~-~ 6~, mercapto, alquitio C~ 1~-~6~, ariltio, arilóxi, arilalquiltio C~ 1~-~ 6~, alquilsulfinila c~ 1~-~ 6~alquilsulfonila C~ 1~-~ 6~, arila, arilamino, Het~ 1~, Het~ 2~.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04102172 | 2004-05-17 | ||
| PCT/EP2005/052265 WO2005111044A1 (en) | 2004-05-17 | 2005-05-17 | 4-substituted-1,5-dihydro-pyrido[3,2-b]indol-2-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0511267A true BRPI0511267A (pt) | 2007-11-27 |
Family
ID=34929107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0511267-2A BRPI0511267A (pt) | 2004-05-17 | 2005-05-17 | 1,5-diidropirido[3,2-b]indol-2-onas 4-substituìdas |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7622582B2 (pt) |
| EP (1) | EP1751165A1 (pt) |
| JP (1) | JP4879889B2 (pt) |
| CN (1) | CN1953982B (pt) |
| AR (1) | AR052304A1 (pt) |
| BR (1) | BRPI0511267A (pt) |
| MX (1) | MXPA06013315A (pt) |
| TW (1) | TW200613307A (pt) |
| WO (1) | WO2005111044A1 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR049102A1 (es) * | 2004-05-17 | 2006-06-28 | Tibotec Pharm Ltd | Derivados de fenil - 1, 5 - dihidro - pirido[3,2 -b]indol - 2 - onas 5- sustituidos y derivados de fenil - 2 - oxo - 1,2 - dihidro - benzo[4, 5]furo[3, 2 -b ]piridin - 3 - carbonitrilo, composiciones farmaceuticas que los contienen y su uso como medicamento con actividad inhibitoria del virus hiv. |
| AU2007233683A1 (en) | 2006-04-03 | 2007-10-11 | Janssen R&D Ireland | HIV inhibiting 3,4-dihydro-imidazo[4,5-b]pyridin-5-ones |
| WO2008037783A1 (en) * | 2006-09-29 | 2008-04-03 | Tibotec Pharmaceuticals Ltd. | Process for preparing 2-oxo-2,5-dihydro-1h-pyrido[3,2-b]indole-3-carbonitriles |
| EP2097416B1 (en) | 2006-12-18 | 2012-09-12 | Amgen, Inc | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| WO2008076427A2 (en) | 2006-12-18 | 2008-06-26 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| CA2683956C (en) | 2007-04-18 | 2012-12-18 | Amgen Inc. | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
| ES2446418T3 (es) | 2007-04-18 | 2014-03-07 | Amgen, Inc | Derivados de indanona que inhiben la prolil hidroxilasa |
| EP2155746A2 (en) | 2007-05-04 | 2010-02-24 | Amgen, Inc | Diazaquinolones that inhibit prolyl hydroxylase activity |
| CA2685216C (en) | 2007-05-04 | 2014-07-08 | Amgen Inc. | Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity |
| NZ590747A (en) * | 2008-07-28 | 2012-11-30 | Gilead Sciences Inc | Cycloalkylidene and heterocycloalkylidene hdac inhibitor compounds |
| BRPI1014821A2 (pt) | 2009-04-09 | 2016-04-05 | Boehringer Ingelheim Int | "inibidores de replicação de hiv" |
| WO2015088565A1 (en) * | 2013-12-13 | 2015-06-18 | Sunovion Pharmaceuticals Inc. | P2x4 receptor modulating compounds and methods of use thereof |
| WO2015088564A1 (en) * | 2013-12-13 | 2015-06-18 | Sunovion Pharmaceuticals Inc. | P2x4 receptor modulating compounds |
| MX392538B (es) | 2015-02-02 | 2025-03-24 | Forma Therapeutics Inc | Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac) |
| WO2016126726A1 (en) | 2015-02-02 | 2016-08-11 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| PH30929A (en) | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| EP0721331B1 (en) | 1993-10-01 | 2001-12-05 | AstraZeneca AB | Process i |
| KR19990044257A (ko) | 1996-05-20 | 1999-06-25 | 디르크 반테 | 생체이용율이 개선된 항진균성 조성물 |
| ATE241969T1 (de) | 1997-03-26 | 2003-06-15 | Janssen Pharmaceutica Nv | Tabletten mit einem kern, der mit einem pilzbekämpfungsmittel und einem polymeren beschichtet ist |
| ID27502A (id) * | 1998-04-27 | 2001-04-12 | Ct Nat De La Rech Scient Cs | Turunan-turunan 3-(amino-atau aminoalkil) piridinon dan penggunannya untuk pengobatan penyakit-penyakit yang berkaitan dengan hiv |
| AU2002246659A1 (en) * | 2000-12-18 | 2002-08-06 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Healt | Benzoylalkylindolepyridinium compounds and pharmaceutical compositions comprising such compounds |
| WO2002055520A2 (en) | 2000-12-18 | 2002-07-18 | Us Health | Benzoylalkylindolepyridinium compounds and pharmaceutical compositions comprising such compounds |
| BR0316209A (pt) * | 2002-11-15 | 2005-09-27 | Tibotec Pharm Ltd | Indolpiridìnio substituìdo como compostos antiinfecciosos |
-
2005
- 2005-05-17 BR BRPI0511267-2A patent/BRPI0511267A/pt not_active IP Right Cessation
- 2005-05-17 US US11/569,108 patent/US7622582B2/en not_active Expired - Fee Related
- 2005-05-17 EP EP05752659A patent/EP1751165A1/en not_active Withdrawn
- 2005-05-17 TW TW094116033A patent/TW200613307A/zh unknown
- 2005-05-17 WO PCT/EP2005/052265 patent/WO2005111044A1/en not_active Ceased
- 2005-05-17 JP JP2007517255A patent/JP4879889B2/ja not_active Expired - Fee Related
- 2005-05-17 MX MXPA06013315A patent/MXPA06013315A/es active IP Right Grant
- 2005-05-17 CN CN200580015617XA patent/CN1953982B/zh not_active Expired - Fee Related
- 2005-05-17 AR ARP050102019A patent/AR052304A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1751165A1 (en) | 2007-02-14 |
| CN1953982B (zh) | 2011-07-06 |
| WO2005111044A1 (en) | 2005-11-24 |
| US20070213320A1 (en) | 2007-09-13 |
| JP2007538052A (ja) | 2007-12-27 |
| CN1953982A (zh) | 2007-04-25 |
| US7622582B2 (en) | 2009-11-24 |
| JP4879889B2 (ja) | 2012-02-22 |
| AR052304A1 (es) | 2007-03-14 |
| MXPA06013315A (es) | 2007-02-02 |
| TW200613307A (en) | 2006-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DA 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2204 DE 02/04/2013. |