BRPI0511764B8 - método de prevenção de agregação de vírions de vírus adeno-associado recombinante (raav) em uma preparação purificada de virions raav - Google Patents

método de prevenção de agregação de vírions de vírus adeno-associado recombinante (raav) em uma preparação purificada de virions raav

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Publication number
BRPI0511764B8
BRPI0511764B8 BRPI0511764A BRPI0511764A BRPI0511764B8 BR PI0511764 B8 BRPI0511764 B8 BR PI0511764B8 BR PI0511764 A BRPI0511764 A BR PI0511764A BR PI0511764 A BRPI0511764 A BR PI0511764A BR PI0511764 B8 BRPI0511764 B8 BR PI0511764B8
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BR
Brazil
Prior art keywords
virions
aggregation
raav
aav
solutions
Prior art date
Application number
BRPI0511764A
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English (en)
Inventor
Qu Guang
Fraser Wright John
Original Assignee
Avigen Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35462907&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0511764(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avigen Inc filed Critical Avigen Inc
Publication of BRPI0511764A publication Critical patent/BRPI0511764A/pt
Publication of BRPI0511764B1 publication Critical patent/BRPI0511764B1/pt
Publication of BRPI0511764B8 publication Critical patent/BRPI0511764B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Lubricants (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)

Abstract

composições e métodos para prevenir a agregação de vetor de aav. a presente invenção refere-se a composições e a métodos que são fornecidos para a preparação de soluções de matéria-prima concentradas de vírions de aav sem a agregação. as formulações para a preparação e armazenagem de aav são soluções de força iônica elevada (por exemplo, <109> ~500mm) que são apesar de tudo isotônicas com o tecido-alvo pretendido. esta combinação, de força iônica elevada e osmolaridade modesta, são obtidas empregando sais de valência elevada, tal como citrato de sódio. as soluções de matéria-prima aav acima de 6,4x10^ ¹³^ são possíveis empregando as formulações da invenção, com nenhuma agregação sendo observada mesmo após dez ciclos de congelamento-descongelamento. o tensoativo pluronic<32>f68 pode ser adicionado em 0,001% para impedir perdas de vírions para superfícies durante o manuseio. as preparações de vírions podem também ser tratadas com nucleases para eliminar pequenos filamentos de ácido nucléico em superfícies de vírions que exacerba a agregação.
BRPI0511764A 2004-06-01 2005-06-01 método de prevenção de agregação de vírions de vírus adeno-associado recombinante (raav) em uma preparação purificada de virions raav BRPI0511764B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US57599704P 2004-06-01 2004-06-01
US60/575,997 2004-06-01
US63922204P 2004-12-22 2004-12-22
US60/639,222 2004-12-22
PCT/US2005/019235 WO2005118792A1 (en) 2004-06-01 2005-06-01 Compositions and methods to prevent aav vector aggregation

Publications (3)

Publication Number Publication Date
BRPI0511764A BRPI0511764A (pt) 2008-01-08
BRPI0511764B1 BRPI0511764B1 (pt) 2017-10-24
BRPI0511764B8 true BRPI0511764B8 (pt) 2021-05-25

Family

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BRPI0511764A BRPI0511764B8 (pt) 2004-06-01 2005-06-01 método de prevenção de agregação de vírions de vírus adeno-associado recombinante (raav) em uma preparação purificada de virions raav

Country Status (11)

Country Link
US (4) US7704721B2 (pt)
EP (3) EP3290513B1 (pt)
JP (5) JP2008501339A (pt)
BR (1) BRPI0511764B8 (pt)
CA (1) CA2569244C (pt)
CY (1) CY1125798T1 (pt)
DK (2) DK3290513T3 (pt)
ES (2) ES2647477T3 (pt)
HU (2) HUE035418T2 (pt)
MX (3) MX360727B (pt)
WO (1) WO2005118792A1 (pt)

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US7704721B2 (en) 2010-04-27
ES2932278T3 (es) 2023-01-17
EP1751275A1 (en) 2007-02-14
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JP2019058177A (ja) 2019-04-18
JP5769650B2 (ja) 2015-08-26
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US20160083694A1 (en) 2016-03-24
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WO2005118792A1 (en) 2005-12-15
MX2019006353A (es) 2022-06-27
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US20110076744A1 (en) 2011-03-31
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US20170247664A1 (en) 2017-08-31
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EP1751275B1 (en) 2017-08-16
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BRPI0511764B1 (pt) 2017-10-24
US9051542B2 (en) 2015-06-09

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