BRPI0511776A - vìrus atenuado de influenza de suìnos, formulação imunogênica, formulação farmacêutica, métodos para imunizar ou induzir uma resposta imune em um porco, para tratar uma infecção por vìrus de influenza de suìnos em um porco, para tratar cáncer em um porco, e para produzir uma formulação imunogênica, célula, linhagem de células de porco, e, ovo embrionado - Google Patents

vìrus atenuado de influenza de suìnos, formulação imunogênica, formulação farmacêutica, métodos para imunizar ou induzir uma resposta imune em um porco, para tratar uma infecção por vìrus de influenza de suìnos em um porco, para tratar cáncer em um porco, e para produzir uma formulação imunogênica, célula, linhagem de células de porco, e, ovo embrionado

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Publication number
BRPI0511776A
BRPI0511776A BRPI0511776-3A BRPI0511776A BRPI0511776A BR PI0511776 A BRPI0511776 A BR PI0511776A BR PI0511776 A BRPI0511776 A BR PI0511776A BR PI0511776 A BRPI0511776 A BR PI0511776A
Authority
BR
Brazil
Prior art keywords
pig
swine influenza
influenza virus
formulation
cell
Prior art date
Application number
BRPI0511776-3A
Other languages
English (en)
Inventor
Peter Palese
Adolfo Garcia-Sastre
Richard J Webby
Juergen A Richt
Robert Webster
Kelly M Lager
Original Assignee
Sinai School Medicine
St Jude Childrens Res Hospital
Us Agriculture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine, St Jude Childrens Res Hospital, Us Agriculture filed Critical Sinai School Medicine
Priority to BR122015032743-1A priority Critical patent/BR122015032743B1/pt
Publication of BRPI0511776A publication Critical patent/BRPI0511776A/pt
Publication of BRPI0511776B1 publication Critical patent/BRPI0511776B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
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  • Microbiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Communicable Diseases (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

VìRUS ATENUADO DE INFLUENZA DE SUìNOS, FORMULAçãO IMUNOGêNICA, FORMULAçãO FARMACêUTICA, MéTODOS PARA IMUNIZAR OU INDUZIR UMA RESPOSTA IMUNE EM UM PORCO, PARA TRATAR UMA INFECçãO POR VìRUS DE INFLUENZA DE SUìNOS EM UM PORCO, PARA TRATAR CáNCER EM UM PORCO, E PARA PRODUZIR UMA FORMULAçãO IMUNOGêNICA, CéLULA, LINHAGEM DE CéLULAS DE PORCO, E, OVO EMBRIONADO. A presente invenção refere-se, em geral, a vírus atenuados de influenza de suínos tendo uma capacidade afetada para antagonizar resposta a interferon celular (IFN), e ao uso destes vírus atenuados em vacinas e formulações farmacêuticas. Em particular, a invenção refere-se a vírus atenuados de influenza de suínos tendo modificações para um gene NS1 de suínos que diminuem ou eliminam a capacidade do produto de gene NS1 de antagonizar a resposta IFN celular. Estes vírus replicam in vivo, mas demonstram replicação diminuída, virulência e aumentada atenuação e, assim, são bem apropriados para uso em vacinas de vírus vivos, e formulações farmacêuticas.
BRPI0511776A 2004-06-01 2005-06-01 vírus atenuado de influenza de suínos geneticamente engenheirado, formulação imunogênica, formulação farmacêutica, uso da formulação imunogênica, uso do vírus atenuado de influenza de suínos geneticamente engenheirado, uso da formulação farmacêutica e método para produzir uma vacina, uma formulação imunogênica ou uma formulação farmacêutica BRPI0511776B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122015032743-1A BR122015032743B1 (pt) 2004-06-01 2005-06-01 Vírus atenuado de influenza de suínos geneticamente engenheirado, formulação imunogênica, formulação farmacêutica, seus usos e métodos para produzir uma vacina

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57641804P 2004-06-01 2004-06-01
PCT/US2005/019382 WO2006083286A2 (en) 2004-06-01 2005-06-01 Genetically engineered swine influenza virus and uses thereof

Publications (2)

Publication Number Publication Date
BRPI0511776A true BRPI0511776A (pt) 2008-01-15
BRPI0511776B1 BRPI0511776B1 (pt) 2016-11-29

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ID=36777648

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Application Number Title Priority Date Filing Date
BRPI0511776A BRPI0511776B1 (pt) 2004-06-01 2005-06-01 vírus atenuado de influenza de suínos geneticamente engenheirado, formulação imunogênica, formulação farmacêutica, uso da formulação imunogênica, uso do vírus atenuado de influenza de suínos geneticamente engenheirado, uso da formulação farmacêutica e método para produzir uma vacina, uma formulação imunogênica ou uma formulação farmacêutica
BR122015032743-1A BR122015032743B1 (pt) 2004-06-01 2005-06-01 Vírus atenuado de influenza de suínos geneticamente engenheirado, formulação imunogênica, formulação farmacêutica, seus usos e métodos para produzir uma vacina

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122015032743-1A BR122015032743B1 (pt) 2004-06-01 2005-06-01 Vírus atenuado de influenza de suínos geneticamente engenheirado, formulação imunogênica, formulação farmacêutica, seus usos e métodos para produzir uma vacina

Country Status (8)

Country Link
US (5) US8124101B2 (pt)
EP (3) EP3332803B1 (pt)
CN (2) CN1993140A (pt)
BR (2) BRPI0511776B1 (pt)
CA (1) CA2610632C (pt)
DK (2) DK1773384T3 (pt)
ES (2) ES2552774T3 (pt)
WO (1) WO2006083286A2 (pt)

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