BRPI0511941A - uso de (s, s)-reboxetina ou reboxetina racêmica - Google Patents
uso de (s, s)-reboxetina ou reboxetina racêmicaInfo
- Publication number
- BRPI0511941A BRPI0511941A BRPI0511941-3A BRPI0511941A BRPI0511941A BR PI0511941 A BRPI0511941 A BR PI0511941A BR PI0511941 A BRPI0511941 A BR PI0511941A BR PI0511941 A BRPI0511941 A BR PI0511941A
- Authority
- BR
- Brazil
- Prior art keywords
- pain
- reboxetine
- racemic
- medicament
- manufacture
- Prior art date
Links
- CBQGYUDMJHNJBX-OALUTQOASA-N (2S)-2-[(S)-(2-ethoxyphenoxy)-phenylmethyl]morpholine Chemical compound CCOC1=CC=CC=C1O[C@@H](C=1C=CC=CC=1)[C@H]1OCCNC1 CBQGYUDMJHNJBX-OALUTQOASA-N 0.000 title abstract 5
- 229960003770 reboxetine Drugs 0.000 title abstract 4
- CBQGYUDMJHNJBX-RTBURBONSA-N reboxetine Chemical compound CCOC1=CC=CC=C1O[C@H](C=1C=CC=CC=1)[C@@H]1OCCNC1 CBQGYUDMJHNJBX-RTBURBONSA-N 0.000 title abstract 3
- 208000002193 Pain Diseases 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 208000008035 Back Pain Diseases 0.000 abstract 1
- 206010058019 Cancer Pain Diseases 0.000 abstract 1
- 206010016059 Facial pain Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 206010065390 Inflammatory pain Diseases 0.000 abstract 1
- 206010024453 Ligament sprain Diseases 0.000 abstract 1
- 208000023178 Musculoskeletal disease Diseases 0.000 abstract 1
- 208000001738 Nervous System Trauma Diseases 0.000 abstract 1
- 208000001294 Nociceptive Pain Diseases 0.000 abstract 1
- 206010065016 Post-traumatic pain Diseases 0.000 abstract 1
- 208000004550 Postoperative Pain Diseases 0.000 abstract 1
- 206010038419 Renal colic Diseases 0.000 abstract 1
- 208000010040 Sprains and Strains Diseases 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000036997 mental performance Effects 0.000 abstract 1
- 230000036651 mood Effects 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 208000009935 visceral pain Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
USO DE (S,S)-REBOXETINA OU REBOXETINA RACêMICA. A presente invenção refere-se ao uso de (S,S)-reboxetina ou reboxetina racêmica, ou de um sal farmaceuticamente aceitável da mesma, na fabricação de um medicamento para o tratamento de uma condição de dor selecionada entre dor neuropática, dor nociceptiva, dor de câncer, dor dorsal, dor inflamatória, distúrbios musculoesqueléticos, dor visceral, dor de esforços/entorses, dor pós-operatória, dor pós-traumática, queimaduras, cólica renal, dor aguda, traumatismo do sistema nervoso central, dor de cabeça, e dor orofacial. Descreve-se também o uso (S,S)-reboxetina ou de um sal famaceuticamente aceitável da mesma, na fabricação de um medicamento para o tratamento de dor em um paciente refratário a um ligante de alfa-2-delta, e também o uso de (S,S)-reboxetina ou reboxetina racêmica, ou de um sal farmaceuticamente aceitável da mesma, na fabricação de um medicamento para uso como um intensificador do desempenho mental ou do humor.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0412878A GB0412878D0 (en) | 2004-06-09 | 2004-06-09 | Use |
| US58865204P | 2004-07-16 | 2004-07-16 | |
| GB0425061A GB0425061D0 (en) | 2004-11-12 | 2004-11-12 | Use |
| US63442704P | 2004-12-07 | 2004-12-07 | |
| PCT/IB2005/001904 WO2006000903A2 (en) | 2004-06-09 | 2005-05-27 | Use of reboxetine for the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0511941A true BRPI0511941A (pt) | 2008-01-22 |
Family
ID=34979099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0511941-3A BRPI0511941A (pt) | 2004-06-09 | 2005-05-27 | uso de (s, s)-reboxetina ou reboxetina racêmica |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080261984A1 (pt) |
| EP (1) | EP1763354A2 (pt) |
| JP (1) | JP2008501778A (pt) |
| KR (1) | KR20070029740A (pt) |
| AU (1) | AU2005256944A1 (pt) |
| BR (1) | BRPI0511941A (pt) |
| CA (1) | CA2567365A1 (pt) |
| IL (1) | IL178827A0 (pt) |
| MX (1) | MXPA06014389A (pt) |
| NO (1) | NO20064642L (pt) |
| RU (1) | RU2006143659A (pt) |
| WO (1) | WO2006000903A2 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090233959A1 (en) | 2008-02-19 | 2009-09-17 | Adolor Corporation | Beloxepin and analogs for the treatment of pain |
| US20130310385A1 (en) * | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants |
| US9320725B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid |
| US9345689B2 (en) | 2012-05-18 | 2016-05-24 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N, N-dimethyl-4-phenyl-4,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and an anticonvulsant |
| EP3782627A4 (en) * | 2018-04-17 | 2021-07-07 | Shanghai Tonglian Pharmaceutical Co., Ltd. | MEDICINAL PRODUCT USED TO PREVENT AND / OR TREAT PAIN AND / OR FEVER, A COMBINATION PRODUCT, AND USE OF THEM |
| WO2019222850A1 (en) * | 2018-05-23 | 2019-11-28 | Wex Pharmaceuticals Inc. | Synergistic tetrodotoxin formulations and methods of treatment for neuropathic pain |
| WO2019245975A1 (en) * | 2018-06-17 | 2019-12-26 | Axsome Therapeutics, Inc. | Compositions for delivery of reboxetine |
| US11020402B2 (en) | 2018-10-15 | 2021-06-01 | Axsome Therapeutics, Inc. | Use of reboxetine to treat narcolepsy |
| US20200147093A1 (en) | 2018-10-15 | 2020-05-14 | Axsome Therapeutics, Inc. | Use of esreboxetine to treat nervous system disorders such as fibromyalgia |
| BR112021007019A2 (pt) * | 2018-10-15 | 2021-07-13 | Axsome Therapeutics, Inc. | uso de reboxetina para tratar narcolepsia |
| US12616702B2 (en) * | 2019-12-03 | 2026-05-05 | Axsome Therapeutics, Inc. | Use of reboxetine to treat narcolepsy |
| CR20220247A (es) * | 2019-12-03 | 2022-08-18 | Axsome Therapeutics Inc | Uso de reboxetina para tratar los trastornos del sistema nervioso |
| US20260174699A1 (en) * | 2024-12-23 | 2026-06-25 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising uniform blends of reboxetine |
| US12565478B1 (en) | 2025-01-21 | 2026-03-03 | Axsome Therapeutics, Inc. | (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)-4-nitrosomorpholine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US422449A (en) * | 1890-03-04 | Gage for gas-cocks | ||
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| ATE305788T1 (de) * | 1999-07-01 | 2005-10-15 | Pharmacia & Upjohn Co Llc | (s,s)-reboxetin zur behandlung von inkontinenz |
| SI1196172T1 (sl) * | 1999-07-01 | 2006-06-30 | Pharmacia & Upjohn Co Llc | (S,S)-reboksetin za zdravljenje kronicne bolecine |
| US20040204411A1 (en) * | 2002-12-17 | 2004-10-14 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
| MXPA06002778A (es) * | 2003-09-09 | 2006-06-14 | Pfizer Prod Inc | Combinacion de inhibidores de recaptacion de serotonina e inhibidores de recaptacion de norepinefrina. |
| ATE449633T1 (de) * | 2003-09-12 | 2009-12-15 | Pfizer | Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern |
-
2005
- 2005-05-27 BR BRPI0511941-3A patent/BRPI0511941A/pt not_active IP Right Cessation
- 2005-05-27 RU RU2006143659/152006143659/15A patent/RU2006143659A/ru not_active Application Discontinuation
- 2005-05-27 WO PCT/IB2005/001904 patent/WO2006000903A2/en not_active Ceased
- 2005-05-27 MX MXPA06014389A patent/MXPA06014389A/es not_active Application Discontinuation
- 2005-05-27 US US11/570,280 patent/US20080261984A1/en not_active Abandoned
- 2005-05-27 CA CA002567365A patent/CA2567365A1/en not_active Abandoned
- 2005-05-27 JP JP2007526596A patent/JP2008501778A/ja not_active Withdrawn
- 2005-05-27 EP EP05758534A patent/EP1763354A2/en not_active Withdrawn
- 2005-05-27 AU AU2005256944A patent/AU2005256944A1/en not_active Abandoned
- 2005-05-27 KR KR1020067025877A patent/KR20070029740A/ko not_active Ceased
-
2006
- 2006-10-12 NO NO20064642A patent/NO20064642L/no not_active Application Discontinuation
- 2006-10-23 IL IL178827A patent/IL178827A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080261984A1 (en) | 2008-10-23 |
| MXPA06014389A (es) | 2007-02-19 |
| AU2005256944A1 (en) | 2006-01-05 |
| WO2006000903A2 (en) | 2006-01-05 |
| CA2567365A1 (en) | 2006-01-05 |
| WO2006000903A3 (en) | 2006-06-08 |
| IL178827A0 (en) | 2007-03-08 |
| NO20064642L (no) | 2006-11-13 |
| EP1763354A2 (en) | 2007-03-21 |
| RU2006143659A (ru) | 2008-06-20 |
| JP2008501778A (ja) | 2008-01-24 |
| KR20070029740A (ko) | 2007-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |