BRPI0512081A - azaporfirinas substituìdas como rótulos de fluorescência - Google Patents

azaporfirinas substituìdas como rótulos de fluorescência

Info

Publication number
BRPI0512081A
BRPI0512081A BRPI0512081-0A BRPI0512081A BRPI0512081A BR PI0512081 A BRPI0512081 A BR PI0512081A BR PI0512081 A BRPI0512081 A BR PI0512081A BR PI0512081 A BRPI0512081 A BR PI0512081A
Authority
BR
Brazil
Prior art keywords
substituted
fluorescence labels
azaporphyrins
products
present
Prior art date
Application number
BRPI0512081-0A
Other languages
English (en)
Inventor
Walter B Dandliker
Mao Lin Hsu
Jr William P Murphy
Original Assignee
Hannjoerg Hereth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hannjoerg Hereth filed Critical Hannjoerg Hereth
Publication of BRPI0512081A publication Critical patent/BRPI0512081A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

AZAPORFIRINAS SUBSTITUìDAS COMO RóTULOS DE FLUORESCêNCIA A presente invenção refere-se a componentes marcadores, sondas fluorescentes, oligonucleotídeos, ensaios de hibridação e imunoensaios usando tais produtos e a métodos para fabricação de tais produtos. De acordo com a presente invenção, componentes marcadores de forma detectável rotulados são proporcionados, os quais compreendem uma porção fluorescente acoplada a dois pequenos grupos de solubilização, um sobre cada lado do plano molecular, a referida porção fluorescente tendo substituintes para controlar a carga líquida de modo a reduzir ou remover os problemas de sensibilidade ao solvente e ligação não específica.
BRPI0512081-0A 2004-06-14 2005-05-18 azaporfirinas substituìdas como rótulos de fluorescência BRPI0512081A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/866,361 US7371524B2 (en) 2003-06-17 2004-06-14 Substituted azaporphyrins as fluorescence labels
PCT/US2005/017352 WO2006001944A1 (en) 2004-06-14 2005-05-18 Substituted azaporphyrins as fluorescence labels

Publications (1)

Publication Number Publication Date
BRPI0512081A true BRPI0512081A (pt) 2008-02-06

Family

ID=35460986

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512081-0A BRPI0512081A (pt) 2004-06-14 2005-05-18 azaporfirinas substituìdas como rótulos de fluorescência

Country Status (7)

Country Link
US (1) US7371524B2 (pt)
EP (1) EP1758917A4 (pt)
JP (1) JP2008502681A (pt)
KR (1) KR20070069125A (pt)
CN (1) CN101035800A (pt)
BR (1) BRPI0512081A (pt)
WO (1) WO2006001944A1 (pt)

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US20080003694A1 (en) * 2006-04-18 2008-01-03 Swanson Basil I Robust, self-assembled, biocompatible films
US7706700B2 (en) 2007-03-21 2010-04-27 Xerox Corporation System and method for authenticating an electrostatographic material in an image forming apparatus
US7715733B2 (en) 2007-03-21 2010-05-11 Xerox Corporation System and method for authenticating a fuser lubricant in an image forming apparatus
US7495214B2 (en) 2007-03-21 2009-02-24 Xerox Corporation Systems and methods for material authentication
EP2065705B1 (en) * 2007-11-30 2011-07-27 Roche Diagnostics GmbH Stabilization of conjugates comprising a thiourea linker
US10759824B2 (en) 2008-09-03 2020-09-01 Quantumdx Group Limited Design, synthesis and use of synthetic nucleotides comprising charge mass tags
EP3002288B1 (en) 2008-09-03 2019-12-04 Quantumdx Group Limited Design, synthesis and use of synthetic nucleotides comprising ionic reporter groups
EP2321429B1 (en) 2008-09-03 2016-08-17 Quantumdx Group Limited Methods and kits for nucleic acid sequencing
US20100267049A1 (en) * 2009-04-15 2010-10-21 Rutter William J Diagnostic devices and related methods
CN102183647A (zh) * 2011-01-24 2011-09-14 杭州师范大学 一种乙型肝炎病毒表面抗原的检测试剂及检测方法
WO2015063692A1 (en) * 2013-10-31 2015-05-07 Sabic Global Technologies B.V. Process for making axially fluorinated-phthalocyanines and their use in photovoltaic applications
EP3400444A4 (en) 2016-01-04 2019-10-16 QuantuMDx Group Limited DESIGN, SYNTHESIS AND USE OF SYNTHETIC NUCLEOTIDES WITH LOADING MASS MARKINGS
CN119264211A (zh) 2018-08-27 2025-01-07 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
JP7280577B2 (ja) * 2019-04-22 2023-05-24 東洋インキＳｃホールディングス株式会社 蛍光バイオイメージング方法
WO2022018264A1 (en) * 2020-07-23 2022-01-27 Technische Universität München Silicon-containing ligand compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494793A (en) * 1986-12-15 1996-02-27 British Technology Group Usa Inc. Monomeric phthalocyanine reagents
US5346670A (en) * 1986-12-24 1994-09-13 British Technology Group U.S.A. Inc. Phthalocyanine and tetrabenztriazaporphyrin reagents
US5135717A (en) * 1986-12-24 1992-08-04 British Technology Group Usa Inc. Tetrabenztriazaporphyrin reagents and kits containing the same
EP0434727A4 (en) * 1988-09-08 1994-08-17 Ultra Diagnostic Corp Red-shifted phthalocyanine and tetrabenztriazaporphyrin reagents
US5606045A (en) * 1990-05-15 1997-02-25 Diatron Corporation Nucleic acid probes and methods
ES2163393T3 (es) * 1990-05-15 2002-02-01 Hyperion Inc Porfirina fluorescente y ftalocianina fluorescente - derivados de polietilenglicol, poliol y sacaridos como sondas fluorescentes.
CA2082936C (en) * 1990-05-15 2003-09-23 Peter O. G. Arrhenius Fluorescent porphyrin, and fluorescent phthalocyanine-polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
US5880287A (en) * 1990-05-15 1999-03-09 Hyperion, Inc. Polyoxyhydrocarbyl related products and methods for fluorescence assays
US5641878A (en) * 1991-05-15 1997-06-24 Diatron Corporation Porphyrin, azaporphyrin, and related fluorescent dyes free of aggregation and serum binding
US6060598A (en) * 1990-05-15 2000-05-09 Hyperion, Inc. Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
US5846703A (en) * 1990-05-15 1998-12-08 Diatron Corporation Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
US5919922A (en) * 1990-05-15 1999-07-06 Hyperion, Inc. Fluorescent dyes free of aggregation and serum binding
JPH05194942A (ja) * 1992-01-23 1993-08-03 Hitachi Chem Co Ltd 蛍光標識用色素、蛍光標識用色素で標識された生物由来物質、及びそれらを含有する試薬
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DE19923168A1 (de) * 1999-05-20 2000-11-23 Roche Diagnostics Gmbh Neue Fluoreszenzfarbstoffe und ihre Verwendung als Fluoreszenzmarker

Also Published As

Publication number Publication date
WO2006001944A1 (en) 2006-01-05
CN101035800A (zh) 2007-09-12
JP2008502681A (ja) 2008-01-31
US20050277119A1 (en) 2005-12-15
EP1758917A1 (en) 2007-03-07
EP1758917A4 (en) 2009-11-11
KR20070069125A (ko) 2007-07-02
US7371524B2 (en) 2008-05-13

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.