BRPI0512256A - método para caracterizar o estágio de desenvolvimento ou patologia de uma amostra de tecido; método de identificação de uma célula de interesse ou de sincìcios multe-nuclear de interesse; método para diagnóstico de pré-neoplasia ou neoplasia; métodos de identificação de um ou mais agentes anti-tumorìgenos e método de preparação de uma amostra de tecido de mamìfero adequada para a identificação de células - Google Patents

método para caracterizar o estágio de desenvolvimento ou patologia de uma amostra de tecido; método de identificação de uma célula de interesse ou de sincìcios multe-nuclear de interesse; método para diagnóstico de pré-neoplasia ou neoplasia; métodos de identificação de um ou mais agentes anti-tumorìgenos e método de preparação de uma amostra de tecido de mamìfero adequada para a identificação de células

Info

Publication number
BRPI0512256A
BRPI0512256A BRPI0512256-2A BRPI0512256A BRPI0512256A BR PI0512256 A BRPI0512256 A BR PI0512256A BR PI0512256 A BRPI0512256 A BR PI0512256A BR PI0512256 A BRPI0512256 A BR PI0512256A
Authority
BR
Brazil
Prior art keywords
interest
neoplasia
identifying
tissue sample
cell
Prior art date
Application number
BRPI0512256-2A
Other languages
English (en)
Inventor
Elena V Gostjeva
William G Thilly
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of BRPI0512256A publication Critical patent/BRPI0512256A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

MéTODO PARA CARACTERIZAR O ESTáGIO DE DESENVOLVIMENTO OU PATOLOGIA DE UMA AMOSTRA DE TECIDO; MéTODO DE IDENTIFICAçãO DE UMA CéLULA DE INTERESSE OU DE SINCìCIOS MULTE-NUCLEAR DE INTERESSE; MéTODO PARA DIAGNóSTICO DE PRé-NEOPLASIA OU NEOPLASIA MéTODOS DE IDENTIFICAçãO DE UM OU MAIS AGENTES ANTI-TUMORìGENOS E MéTODO DE PREPARAçãO DE UMA AMOSTRA DE TECIDO DE MAMìFERO ADEQUADA PARA A IDENTIFICAçãO DE CéLULAS Trata-se da descrição de métodos para identificação de células tronco e outras células específicas para embriogênese e carcinogênese, classificando amostras de tecido, diagnosticando lesões pré-cancerosas e cancerosas ou arteriosclerose, testando o valor de agentes contra o câncer, descobrindo macromoléculas especificamente expressas em tipos de célula específicos, usando células tronco na terapia restauradora de tecido, bem como métodos para preparação de amostras de tecidos de modo que os tipos morfológicos nucleares heteromórficos permaneçam intactos.
BRPI0512256-2A 2004-06-17 2005-06-17 método para caracterizar o estágio de desenvolvimento ou patologia de uma amostra de tecido; método de identificação de uma célula de interesse ou de sincìcios multe-nuclear de interesse; método para diagnóstico de pré-neoplasia ou neoplasia; métodos de identificação de um ou mais agentes anti-tumorìgenos e método de preparação de uma amostra de tecido de mamìfero adequada para a identificação de células BRPI0512256A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58057504P 2004-06-17 2004-06-17
PCT/US2005/021504 WO2006009860A2 (en) 2004-06-17 2005-06-17 Methods for identifying stem cells based on nuclear morphotypes

Publications (1)

Publication Number Publication Date
BRPI0512256A true BRPI0512256A (pt) 2008-02-19

Family

ID=35735073

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512256-2A BRPI0512256A (pt) 2004-06-17 2005-06-17 método para caracterizar o estágio de desenvolvimento ou patologia de uma amostra de tecido; método de identificação de uma célula de interesse ou de sincìcios multe-nuclear de interesse; método para diagnóstico de pré-neoplasia ou neoplasia; métodos de identificação de um ou mais agentes anti-tumorìgenos e método de preparação de uma amostra de tecido de mamìfero adequada para a identificação de células

Country Status (12)

Country Link
US (5) US7427502B2 (pt)
EP (1) EP1774325B1 (pt)
JP (1) JP5130042B2 (pt)
KR (1) KR101209833B1 (pt)
CN (1) CN101006342B (pt)
AU (1) AU2005265122A1 (pt)
BR (1) BRPI0512256A (pt)
CA (1) CA2570422A1 (pt)
IL (1) IL179972A (pt)
RU (1) RU2007101496A (pt)
WO (1) WO2006009860A2 (pt)
ZA (1) ZA200610596B (pt)

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KR101209833B1 (ko) 2004-06-17 2012-12-07 메사추세츠 인스티튜트 오브 테크놀로지 핵 형태에 기초하여 줄기 세포를 동정하는 방법
US8070312B2 (en) * 2004-08-02 2011-12-06 Orion Energy Systems, Inc. Fluorescent light fixture with lamp catcher
BRPI0619599A2 (pt) * 2005-12-09 2011-10-11 Massachusetts Inst Technology método para inibir células de linhagem de tumor e para inibir o crescimento de tumores em um paciente
WO2008115517A2 (en) * 2007-03-19 2008-09-25 Massachusetts Institute Of Technology Methods for identifying stem cells by detecting autofluorescence of cells and syncytia
EP2171448B1 (en) * 2007-06-13 2012-08-15 Massachusetts Institute of Technology Methods for inhibiting tumor growth by targeting the ssdna replication intermediate of tumor stem cells
EP2344880B1 (en) * 2008-09-24 2015-08-19 Massachusetts Institute of Technology Methods for identifying stem cells by detecting fluorescence of cells and syncytia
EP2423661A1 (de) * 2010-08-30 2012-02-29 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Vorrichtung und Verfahren zum automatisierten Isolieren und Transferieren mindestens einer mikroskopischen Probe von einem Probenträger zu einem Auffangsystem
CA2815787A1 (en) * 2010-10-25 2012-05-10 Massachusetts Institute Of Technology Wound healing metakaryotic stem cells and methods of use thereof
JP6002748B2 (ja) * 2011-03-24 2016-10-05 ザ・ロゴシン・インスティテュート・インコーポレイテッド 癌幹細胞の数を選択的に減少させる化合物をスクリーニングするためのアッセイ
KR20140049993A (ko) 2011-06-02 2014-04-28 메사추세츠 인스티튜트 오브 테크놀로지 메타핵 줄기 세포의 dsRNA/DNA 하이브리드 게놈 복제 중간체
WO2013103365A1 (en) 2012-01-06 2013-07-11 Pioneer Hi-Bred International, Inc. Pollen preferred promoters and methods of use
CN102589943B (zh) * 2012-02-08 2013-09-11 河南省农业科学院 花生根尖细胞染色体有丝分裂中期的制片方法
US10314851B2 (en) 2014-03-17 2019-06-11 Massachusetts Institute Of Technology Metakaryocidal treatments
US20170081698A1 (en) 2014-03-17 2017-03-23 Massachusetts Institute Of Technology Survival assays for metakaryotic stem cells
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
AU2015266594A1 (en) 2014-05-30 2017-01-19 Todd Frank OVOKAITYS Method and system for generation and use of activated stem cells
WO2015187974A1 (en) 2014-06-06 2015-12-10 Ovokaitys Todd Frank Methods and compositions for increasing the bioactivity of nutrients
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
CN112434554B (zh) * 2020-10-16 2023-08-04 中科院成都信息技术股份有限公司 一种基于异质化缩减的云状图像识别方法及系统
US12246037B2 (en) 2020-12-08 2025-03-11 Todd Frank Ovokaitys Methods and systems for increased production of stem cells
CN113865951A (zh) * 2021-08-19 2021-12-31 贵州大学 一种马尾松愈伤组织染色体制片方法

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US7361336B1 (en) 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
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BRPI0619599A2 (pt) 2005-12-09 2011-10-11 Massachusetts Inst Technology método para inibir células de linhagem de tumor e para inibir o crescimento de tumores em um paciente
WO2008115517A2 (en) 2007-03-19 2008-09-25 Massachusetts Institute Of Technology Methods for identifying stem cells by detecting autofluorescence of cells and syncytia
EP2171448B1 (en) 2007-06-13 2012-08-15 Massachusetts Institute of Technology Methods for inhibiting tumor growth by targeting the ssdna replication intermediate of tumor stem cells
EP2344880B1 (en) 2008-09-24 2015-08-19 Massachusetts Institute of Technology Methods for identifying stem cells by detecting fluorescence of cells and syncytia

Also Published As

Publication number Publication date
ZA200610596B (en) 2009-04-29
JP5130042B2 (ja) 2013-01-30
US7977092B2 (en) 2011-07-12
CA2570422A1 (en) 2006-01-26
AU2005265122A1 (en) 2006-01-26
WO2006009860A3 (en) 2006-08-10
EP1774325A2 (en) 2007-04-18
US20160024577A1 (en) 2016-01-28
CN101006342A (zh) 2007-07-25
CN101006342B (zh) 2014-10-29
IL179972A0 (en) 2007-05-15
KR20070040372A (ko) 2007-04-16
RU2007101496A (ru) 2008-07-27
WO2006009860A2 (en) 2006-01-26
US8465943B2 (en) 2013-06-18
US7427502B2 (en) 2008-09-23
IL179972A (en) 2011-09-27
KR101209833B1 (ko) 2012-12-07
US20090098562A1 (en) 2009-04-16
JP2008503726A (ja) 2008-02-07
EP1774325B1 (en) 2016-02-24
US20060063144A1 (en) 2006-03-23
US20090081720A1 (en) 2009-03-26
US20140154672A1 (en) 2014-06-05

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