BRPI0512325A - composto, composição farmacêutica, e, método para a fabricação de um medicamento - Google Patents

composto, composição farmacêutica, e, método para a fabricação de um medicamento

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Publication number
BRPI0512325A
BRPI0512325A BRPI0512325-9A BRPI0512325A BRPI0512325A BR PI0512325 A BRPI0512325 A BR PI0512325A BR PI0512325 A BRPI0512325 A BR PI0512325A BR PI0512325 A BRPI0512325 A BR PI0512325A
Authority
BR
Brazil
Prior art keywords
manufacture
compound
pharmaceutical composition
compounds
medicament
Prior art date
Application number
BRPI0512325-9A
Other languages
English (en)
Inventor
Paul E Finke
Laura C Meurer
Sander G Mills
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BRPI0512325A publication Critical patent/BRPI0512325A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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  • Health & Medical Sciences (AREA)
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Abstract

COMPOSTO, COMPOSIçãO FARMACêUTICA, E, MéTODO PARA A FABRICAçãO DE UM MEDICAMENTO A presente invenção é dirigida a certos compostos de lactama, que são úteis como antagonistas do receptor da neuroquinina- 1 (NK-1), e inibidores da taquiquinina e, em particular, da substância P.A invenção diz respeito também a formulações farmacêuticas compreendendo estes compostos como ingredientes ativos e ao uso dos compostos e suas formulações no tratamento de certos distúrbios, incluindo êmese, incontinência urinária, depressão e ansiedade.
BRPI0512325-9A 2004-06-22 2005-06-17 composto, composição farmacêutica, e, método para a fabricação de um medicamento BRPI0512325A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58178604P 2004-06-22 2004-06-22
PCT/US2005/021840 WO2006002117A1 (en) 2004-06-22 2005-06-17 Lactam tachykinin receptor antagonists

Publications (1)

Publication Number Publication Date
BRPI0512325A true BRPI0512325A (pt) 2008-02-26

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BRPI0512325-9A BRPI0512325A (pt) 2004-06-22 2005-06-17 composto, composição farmacêutica, e, método para a fabricação de um medicamento

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ATE511842T1 (de) 2005-10-04 2011-06-15 Merck Sharp & Dohme Kombinationstherapie zur behandlung von erhöhter miktionsfrequenz, akutem harndrang und inkontinenz
JP2010500351A (ja) * 2006-08-09 2010-01-07 メルク エンド カムパニー インコーポレーテッド ラクタムタキキニン受容体拮抗薬の製造法
AU2008233232A1 (en) * 2007-03-29 2008-10-09 Merck Sharp & Dohme Corp. Combination therapy for the treatment-of lower urinary tract symptoms

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US5387595A (en) * 1992-08-26 1995-02-07 Merck & Co., Inc. Alicyclic compounds as tachykinin receptor antagonists
AU722883B2 (en) * 1995-10-18 2000-08-10 Merck & Co., Inc. Cyclopentyl tachykinin receptor antagonists
US5750549A (en) * 1996-10-15 1998-05-12 Merck & Co., Inc. Cycloalkyl tachykinin receptor antagonists
GB9625843D0 (en) * 1996-12-12 1997-01-29 Merck & Co Inc Phenyl spiroethercycloalkyl tachykinn receptor antagonists
PE20020444A1 (es) * 2000-09-22 2002-06-14 Merck & Co Inc Antagonistas de receptores de taquiquinina zwitterionica

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AU2005258017A1 (en) 2006-01-05
IL180107A0 (en) 2007-05-15
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RU2007102056A (ru) 2008-07-27
NZ551906A (en) 2009-07-31
CN1972910A (zh) 2007-05-30
EP1761488A1 (en) 2007-03-14
WO2006002117A1 (en) 2006-01-05
NO20070355L (no) 2007-03-13
MXPA06014582A (es) 2007-03-23
JP2008503584A (ja) 2008-02-07
AU2005258017B2 (en) 2011-03-17
ZA200610024B (en) 2008-06-25
CA2570813A1 (en) 2006-01-05
KR20070027602A (ko) 2007-03-09

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