BRPI0512379A - composições farmacêuticas compreendendo inibidores de nep, inibidores do sistema de produção de endotelina endógena e antagonista do receptor at1 - Google Patents
composições farmacêuticas compreendendo inibidores de nep, inibidores do sistema de produção de endotelina endógena e antagonista do receptor at1Info
- Publication number
- BRPI0512379A BRPI0512379A BRPI0512379-8A BRPI0512379A BRPI0512379A BR PI0512379 A BRPI0512379 A BR PI0512379A BR PI0512379 A BRPI0512379 A BR PI0512379A BR PI0512379 A BRPI0512379 A BR PI0512379A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- production system
- pharmaceutical compositions
- receptor antagonist
- endogenous endothelin
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 102000002045 Endothelin Human genes 0.000 title abstract 2
- 108050009340 Endothelin Proteins 0.000 title abstract 2
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title abstract 2
- 239000000400 angiotensin II type 1 receptor blocker Substances 0.000 title abstract 2
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 102000003729 Neprilysin Human genes 0.000 abstract 1
- 108090000028 Neprilysin Proteins 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 239000002792 enkephalinase inhibitor Substances 0.000 abstract 1
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 239000011885 synergistic combination Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
COMPOSIçõES FARMACêUTICAS COMPREENDENDO INIBIDORES DE NEP, INIBIDORES DO SISTEMA DE PRODUçãO DE ENDOTELINA ENDóGENA E ANTAGONISTAS DO RECEPTOR AT~1~. A presente invenção refere-se a uma nova terapia de combinação para doenças cardiovasculares, em particular, hipertensão arterial, hipertensão pulmonar e/ou insuficiência cardíaca congestiva, envolvendo a administração de uma combinação sinérgica de pelo menos um inibidor de endopeptidase neutra, pelo menos, um inibidor do sistema de produção de endotelina endógena e, pelo menos, um antagonista do receptor AT~1~.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58172304P | 2004-06-23 | 2004-06-23 | |
| EP04102906 | 2004-06-23 | ||
| PCT/EP2005/052915 WO2006000564A1 (en) | 2004-06-23 | 2005-06-22 | Pharmaceutical compositions comprising nep-inhibitors, inhibitors of the endogenous endothelin producing system and at1-receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0512379A true BRPI0512379A (pt) | 2008-03-11 |
Family
ID=34979877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0512379-8A BRPI0512379A (pt) | 2004-06-23 | 2005-06-22 | composições farmacêuticas compreendendo inibidores de nep, inibidores do sistema de produção de endotelina endógena e antagonista do receptor at1 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1776095A1 (pt) |
| JP (1) | JP2008503546A (pt) |
| CN (1) | CN1972679B (pt) |
| AU (1) | AU2005256634B2 (pt) |
| BR (1) | BRPI0512379A (pt) |
| CA (1) | CA2579716A1 (pt) |
| MX (1) | MXPA06014448A (pt) |
| RU (1) | RU2384346C2 (pt) |
| WO (1) | WO2006000564A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007054975A1 (en) * | 2005-11-08 | 2007-05-18 | Panacea Biotec Ltd | Pharmaceutical compositions for the treatment of cardiovascular and other associated disorders |
| WO2007106708A2 (en) * | 2006-03-10 | 2007-09-20 | Novartis Ag | Combinations of the angiotensin ii antagonist valsartan and the nep inhibitor daglutril |
| EP1891952B1 (en) | 2006-05-04 | 2011-10-05 | LEK Pharmaceuticals d.d. | Pharmaceutical composition of olmesartan medoxomil |
| PE20120593A1 (es) | 2009-01-30 | 2012-05-21 | Takeda Pharmaceutical | Derivados fusionados de pirimidin-4-ona como antagonistas del receptor de angiotensina ii y como agonistas del receptor ppar gamma |
| WO2017072636A1 (en) * | 2015-10-29 | 2017-05-04 | Cadila Healthcare Limited | Pharmaceutical synergistic combination |
| CN105669581B (zh) * | 2015-11-09 | 2017-03-22 | 成都苑东生物制药股份有限公司 | 一种血管紧张受体拮抗剂和中性内肽酶抑制剂复合物 |
| EP3634528B1 (en) | 2017-06-07 | 2023-06-07 | Shifamed Holdings, LLC | Intravascular fluid movement devices, systems, and methods of use |
| US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
| EP3746149B1 (en) | 2018-02-01 | 2025-08-06 | Shifamed Holdings, LLC | Intravascular blood pumps |
| CA3091300A1 (en) * | 2018-02-23 | 2019-08-29 | Beijing Tide Pharmaceutical Co., Ltd. | Receptor inhibitors, pharmaceutical compositions comprising the same, and usage thereof |
| WO2020028537A1 (en) | 2018-07-31 | 2020-02-06 | Shifamed Holdings, Llc | Intravascaular blood pumps and methods of use |
| WO2020073047A1 (en) | 2018-10-05 | 2020-04-09 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| WO2021011473A1 (en) | 2019-07-12 | 2021-01-21 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
| US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
| US12465748B2 (en) | 2019-08-07 | 2025-11-11 | Supira Medical, Inc. | Catheter blood pumps and collapsible pump housings |
| WO2021062260A1 (en) | 2019-09-25 | 2021-04-01 | Shifamed Holdings, Llc | Catheter blood pumps and collapsible blood conduits |
| EP4501393A3 (en) | 2019-09-25 | 2025-04-09 | Shifamed Holdings, LLC | Catheter blood pumps and collapsible pump housings |
| US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
| EP4072650A4 (en) | 2019-12-11 | 2024-01-10 | Shifamed Holdings, LLC | Descending aorta and vena cava blood pumps |
| EP4077947A4 (en) | 2019-12-19 | 2024-01-10 | Shifamed Holdings, LLC | INTRAVASCULAR BLOOD PUMPS, MOTORS AND FLUID CONTROL |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19510566A1 (de) * | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| PT937068E (pt) * | 1996-10-29 | 2002-07-31 | Merck & Co Inc | Processo para a cristalizacao de losartan |
| DE19750002A1 (de) * | 1997-11-12 | 1999-05-20 | Solvay Pharm Gmbh | Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| ZA991922B (en) * | 1998-03-11 | 1999-09-13 | Smithkline Beecham Corp | Novel compositions of eprosartan. |
| HUP0203326A3 (en) * | 1999-08-30 | 2003-04-28 | Sanofi Aventis Deutschland | Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events |
| SK14102003A3 (sk) * | 2001-05-18 | 2004-08-03 | Solvay Pharmaceuticals Gmbh | Použitie zlúčenín s kombinovanou inhibičnou aktivitou k NEP/MP pri príprave liečiv |
| CN100376592C (zh) * | 2001-06-20 | 2008-03-26 | 橘生药品工业株式会社 | 含氮的杂环衍生物、含有该衍生物的药物组合物、其药物应用以及用于该衍生物制备的中间体 |
| PT1467728E (pt) * | 2002-01-17 | 2007-11-14 | Novartis Ag | Composições farmacêuticas compreendendo valsartan e inibidores da nep |
| GB0212412D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Combination of organic compounds |
| EP1578360A4 (en) * | 2002-08-28 | 2009-10-21 | Curis Inc | JOINT ADMINISTRATION OF MORPHOGENES AND ANGIOTENSIN ENZYME CONVERTING INHIBITORS FOR THE TREATMENT OF CHRONIC RENAL FAILURE |
| SA04250283B1 (ar) * | 2003-09-26 | 2008-05-26 | سولفاي فارماسيتيكالز جي أم بي أتش | مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid |
-
2005
- 2005-06-22 EP EP05766754A patent/EP1776095A1/en not_active Withdrawn
- 2005-06-22 WO PCT/EP2005/052915 patent/WO2006000564A1/en not_active Ceased
- 2005-06-22 AU AU2005256634A patent/AU2005256634B2/en not_active Ceased
- 2005-06-22 RU RU2007102227/15A patent/RU2384346C2/ru not_active IP Right Cessation
- 2005-06-22 CA CA002579716A patent/CA2579716A1/en not_active Abandoned
- 2005-06-22 JP JP2007517296A patent/JP2008503546A/ja active Pending
- 2005-06-22 MX MXPA06014448A patent/MXPA06014448A/es active IP Right Grant
- 2005-06-22 CN CN2005800207701A patent/CN1972679B/zh not_active Expired - Fee Related
- 2005-06-22 BR BRPI0512379-8A patent/BRPI0512379A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1972679A (zh) | 2007-05-30 |
| HK1103638A1 (en) | 2007-12-28 |
| MXPA06014448A (es) | 2007-03-01 |
| AU2005256634B2 (en) | 2010-12-09 |
| CA2579716A1 (en) | 2006-01-05 |
| RU2384346C2 (ru) | 2010-03-20 |
| AU2005256634A1 (en) | 2006-01-05 |
| WO2006000564A1 (en) | 2006-01-05 |
| CN1972679B (zh) | 2010-07-28 |
| JP2008503546A (ja) | 2008-02-07 |
| RU2007102227A (ru) | 2008-07-27 |
| EP1776095A1 (en) | 2007-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE AS 8A, 9A E 10A ANUIDADES. |
|
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |