BRPI0512418A - derivado de pirrolpirimidina ou pirrolpiridina substituìdo com um grupo amino cìclico, compostos, antagonista para receptores de crf, uso de um derivado de pirrolpirimidina ou pirrolpiridina substituìdo com um grupo amino cìclico, de um sal do mesmo e de seu hidrato farmaceuticamente aceitáveis - Google Patents

derivado de pirrolpirimidina ou pirrolpiridina substituìdo com um grupo amino cìclico, compostos, antagonista para receptores de crf, uso de um derivado de pirrolpirimidina ou pirrolpiridina substituìdo com um grupo amino cìclico, de um sal do mesmo e de seu hidrato farmaceuticamente aceitáveis

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Publication number
BRPI0512418A
BRPI0512418A BRPI0512418-2A BRPI0512418A BRPI0512418A BR PI0512418 A BRPI0512418 A BR PI0512418A BR PI0512418 A BRPI0512418 A BR PI0512418A BR PI0512418 A BRPI0512418 A BR PI0512418A
Authority
BR
Brazil
Prior art keywords
amino group
cyclic amino
pyrrolpyrimidine
pyrrolpyridine
crf
Prior art date
Application number
BRPI0512418-2A
Other languages
English (en)
Inventor
Atsuro Nakazato
Taketoshi Okubo
Dai Nozawa
Tomoko Tamita
Ludo E J Kennis
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of BRPI0512418A publication Critical patent/BRPI0512418A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/22—Anxiolytics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

DERIVADO DE PIRROLPIRIMIDINA OU PIRROLPIRIDINA SUBSTITUIDO COM UM GRUPO AMINO CìCLICO, COMPOSTOS, ANTAGONISTA PARA RECEPTORES DE CRF, USO DE UM DERIVADO DE PIRROLPIRIMIDINA OU PIRROLPIRIDINA SUBSTITUIDO COM UM GRUPO AMINO CìCLICO, DE UM SAL DO MESMO E DE SEU HIDRATO FARMACEUTICAMENTE ACEITáVEIS Um objetivo da presente invenção é fornecer um antagonista contra receptores de CRF e/ou um agonista para receptores que é eficaz como um agente terapêutico ou profilático para doenças em que o CRF é considerado estar envolvido, tal como depressão, ansiedade, mal de Alzheimer, mal de Parkinson, coréia de Huntington, distúrbios alimentares, hipertensão, doenças gastrointestinais, dependência de medicamento, infarto cerebral, isquemia cerebral, edema cerebral, ferimento externo cefálico, inflamação, doenças relacionadas com a imunidade, alopecia, síndrome do intestino irritável, distúrbios do sono, epilepsia, dermatites, esquizofrenia, dor, etc. Um derivado de pirrolpirimidina ou pirrolpiridina substituído com um grupo amino ciclico representado pela seguinte fórmula ¢I! tem uma afinidade alta quanto a receptores de CRF e/ou receptores de S e é eficaz contra doenças em que o CRF é considerado estar envolvido.
BRPI0512418-2A 2004-06-25 2005-06-24 derivado de pirrolpirimidina ou pirrolpiridina substituìdo com um grupo amino cìclico, compostos, antagonista para receptores de crf, uso de um derivado de pirrolpirimidina ou pirrolpiridina substituìdo com um grupo amino cìclico, de um sal do mesmo e de seu hidrato farmaceuticamente aceitáveis BRPI0512418A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004188128A JP2007161585A (ja) 2004-06-25 2004-06-25 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
PCT/JP2005/012152 WO2006001511A1 (en) 2004-06-25 2005-06-24 Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with a cyclic amino group as crf antagonists

Publications (1)

Publication Number Publication Date
BRPI0512418A true BRPI0512418A (pt) 2008-03-04

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ID=34971526

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512418-2A BRPI0512418A (pt) 2004-06-25 2005-06-24 derivado de pirrolpirimidina ou pirrolpiridina substituìdo com um grupo amino cìclico, compostos, antagonista para receptores de crf, uso de um derivado de pirrolpirimidina ou pirrolpiridina substituìdo com um grupo amino cìclico, de um sal do mesmo e de seu hidrato farmaceuticamente aceitáveis

Country Status (16)

Country Link
US (2) US7951811B2 (pt)
EP (2) EP1758903A1 (pt)
JP (2) JP2007161585A (pt)
KR (1) KR101290992B1 (pt)
CN (2) CN101696208B (pt)
AU (2) AU2005257496B2 (pt)
BR (1) BRPI0512418A (pt)
CA (1) CA2568804C (pt)
IL (1) IL179606A (pt)
MX (1) MXPA06014990A (pt)
NO (1) NO20070466L (pt)
NZ (2) NZ551427A (pt)
RU (1) RU2385321C2 (pt)
UA (1) UA89192C2 (pt)
WO (1) WO2006001511A1 (pt)
ZA (1) ZA200610039B (pt)

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CN110372571B (zh) * 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物
CN111320634A (zh) * 2020-04-14 2020-06-23 浙江工业大学 一种乙酰氧取代的吡咯并[2,3-d]嘧啶衍生物的制备方法
JP2023549738A (ja) 2020-10-30 2023-11-29 １シーバイオ， インコーポレイテッド エクトヌクレオチドピロホスファターゼ－ホスホジエステラーゼ－１（ｅｎｐｐ１）阻害物質及びそれらの使用
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CN101696208A (zh) 2010-04-21
AU2011200450A1 (en) 2011-02-24
WO2006001511A8 (en) 2006-02-23
IL179606A0 (en) 2007-05-15
CN1972940A (zh) 2007-05-30
EP1758903A1 (en) 2007-03-07
JP2008503442A (ja) 2008-02-07
US20080280928A1 (en) 2008-11-13
WO2006001511A1 (en) 2006-01-05
MXPA06014990A (es) 2007-02-08
CN101696208B (zh) 2013-09-25
JP4924037B2 (ja) 2012-04-25
CA2568804C (en) 2014-06-03
UA89192C2 (ru) 2010-01-11
RU2007102699A (ru) 2008-07-27
AU2011200450B2 (en) 2011-05-26
KR20070026637A (ko) 2007-03-08
AU2005257496A1 (en) 2006-01-05
JP2007161585A (ja) 2007-06-28
NZ580117A (en) 2010-07-30
NZ551427A (en) 2009-11-27
NO20070466L (no) 2007-03-20
EP1953160A1 (en) 2008-08-06
HK1139655A1 (en) 2010-09-24
ZA200610039B (en) 2008-08-27
AU2005257496B2 (en) 2011-01-06
US20110124862A1 (en) 2011-05-26
HK1103724A1 (en) 2007-12-28
KR101290992B1 (ko) 2013-07-30
CA2568804A1 (en) 2006-01-05
CN1972940B (zh) 2011-08-10
IL179606A (en) 2011-08-31
RU2385321C2 (ru) 2010-03-27
US7951811B2 (en) 2011-05-31

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