BRPI0513018A - microlaboratório para a análise de fluidos biológicos usando luz branca como fonte de emissão - Google Patents

microlaboratório para a análise de fluidos biológicos usando luz branca como fonte de emissão

Info

Publication number
BRPI0513018A
BRPI0513018A BRPI0513018-2A BRPI0513018A BRPI0513018A BR PI0513018 A BRPI0513018 A BR PI0513018A BR PI0513018 A BRPI0513018 A BR PI0513018A BR PI0513018 A BRPI0513018 A BR PI0513018A
Authority
BR
Brazil
Prior art keywords
analysis
white light
biological fluids
concentration
laboratory
Prior art date
Application number
BRPI0513018-2A
Other languages
English (en)
Inventor
Jose Higino Gomes Correia
Graca Maria Henriques Minas
Jose Carlos De Almeida Ribeiro
Original Assignee
Univ Do Minho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Do Minho filed Critical Univ Do Minho
Publication of BRPI0513018A publication Critical patent/BRPI0513018A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0106—General arrangement of respective parts
    • G01N2021/0112—Apparatus in one mechanical, optical or electronic block
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G01N2021/3166—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths using separate detectors and filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G01N2021/317—Special constructive features
    • G01N2021/3177—Use of spatially separated filters in simultaneous way
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/02—Mechanical
    • G01N2201/022—Casings
    • G01N2201/0221—Portable; cableless; compact; hand-held

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

MICROLABORATóRIO PARA ANáLISE DE FLUIDOS BIOLóGICOS USANDO LUZ BRANCA COMO FONTE DE EMISSãO A presente invenção diz respeito a um micro-sistema laboratorial portátil para análise, em tempo real, de fluidos biológicos, em especial a medição da concentração de biomoléculas nesses fluidos, para aplicação em análises clínicas. Este dispositivo combina num único micro-sistema os microcanais, os filtros ópticos, os detectores e a eletrónica de leitura, ficando habilitado para quantificar a concentração de biomoléculas usando a luz branca como fonte de luz, evitando assim o recurso a uma fonte de luz monocromática específica vinda de um laser, por exemplo. O princípio de funcionamento baseia-se na detecção colorimétrica por absorção óptica. Um feixe de luz branca é direcionado para a câmara de detecção, na qual se encontra a mistura a analisar. Esse feixe é filtrado por um filtro óptico de banda estreita no comprimento de onda adequado. A intensidade da luz transmitida através da mistura, proporcional à concentração da biomolécula em análise, é medida por um fotodetector colocado por baixo da câmara de detecção.
BRPI0513018-2A 2004-07-05 2005-07-01 microlaboratório para a análise de fluidos biológicos usando luz branca como fonte de emissão BRPI0513018A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT103159A PT103159B (pt) 2004-07-05 2004-07-05 Microlaboratório para análise de fluídos biológicos usando luz branca como fonte de emissão
PCT/IB2005/052200 WO2006006113A1 (en) 2004-07-05 2005-07-01 Microlaboratory for biological fluids analysis using white light illumnation

Publications (1)

Publication Number Publication Date
BRPI0513018A true BRPI0513018A (pt) 2008-04-22

Family

ID=34972660

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513018-2A BRPI0513018A (pt) 2004-07-05 2005-07-01 microlaboratório para a análise de fluidos biológicos usando luz branca como fonte de emissão

Country Status (5)

Country Link
US (1) US20070298514A1 (pt)
EP (1) EP1794570A1 (pt)
BR (1) BRPI0513018A (pt)
PT (1) PT103159B (pt)
WO (1) WO2006006113A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008089767A1 (en) * 2007-01-26 2008-07-31 Diramo A/S Stacking of optic sensor and microfluidic-chips with optically communication through windows
EP2249144A3 (en) 2009-05-06 2011-01-26 F. Hoffmann-La Roche AG System and method for the automated analysis of samples
CN102166537B (zh) * 2011-01-30 2013-05-01 南京大学 一种亲水、多功能集成、易于光学检测的微流控芯片及其制法和用途
US20140080225A1 (en) * 2012-09-18 2014-03-20 The Royal Institution For The Advancement Of Learning / Mcgill University Methods and devices for xerogel based sensors
CN103175800B (zh) * 2013-03-11 2015-07-29 中国科学院苏州生物医学工程技术研究所 一种快速测定胰蛋白酶的比色分析方法
WO2016175859A1 (en) 2015-04-30 2016-11-03 Hewlett-Packard Development Company, L.P. Optical spectrometer
US10365226B2 (en) 2015-04-30 2019-07-30 Hewlett-Packard Development Company, L.P. Microfluidic optical fluid sensor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7003010B2 (en) * 2000-11-27 2006-02-21 Zhongshan Liu Multi-group multi-wavelength laser matrix
US7524459B2 (en) * 2002-01-24 2009-04-28 California Institute Of Technology In Pasadena Optoelectronic and microfluidic integration for miniaturized spectroscopic devices
US6843263B2 (en) * 2002-06-24 2005-01-18 Industrial Technology Research Institute Partially closed microfluidic system and microfluidic driving method
US7087444B2 (en) * 2002-12-16 2006-08-08 Palo Alto Research Center Incorporated Method for integration of microelectronic components with microfluidic devices

Also Published As

Publication number Publication date
WO2006006113A1 (en) 2006-01-19
EP1794570A1 (en) 2007-06-13
US20070298514A1 (en) 2007-12-27
PT103159B (pt) 2006-12-29
WO2006006113A9 (en) 2006-10-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.