BRPI0513119A - compostos e métodos modulares de receptores intracelulares - Google Patents

compostos e métodos modulares de receptores intracelulares

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Publication number
BRPI0513119A
BRPI0513119A BRPI0513119-7A BRPI0513119A BRPI0513119A BR PI0513119 A BRPI0513119 A BR PI0513119A BR PI0513119 A BRPI0513119 A BR PI0513119A BR PI0513119 A BRPI0513119 A BR PI0513119A
Authority
BR
Brazil
Prior art keywords
methods
compounds
intracellular receptors
intracellular
modular
Prior art date
Application number
BRPI0513119-7A
Other languages
English (en)
Inventor
I Robert
L Steven
Lin Zhi
E Mark
Yan Liu
S Donalds
Andrew Hudson
Original Assignee
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc
Publication of BRPI0513119A publication Critical patent/BRPI0513119A/pt

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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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Abstract

COMPOSTOS E MéTODOS MODULADORES DE RECEPTORES INTRACELULARES Esta invenção se relaciona a compostos de acordo com uma Fórmula I, II ou III, com as definições de R1-R10 de acordo com a reivindicação 1, que se ligam a receptores intracelulares e/ou modulam a atividade de receptores intracelulares, e a métodos para fazer e usar tais compostos.
BRPI0513119-7A 2004-07-14 2005-07-12 compostos e métodos modulares de receptores intracelulares BRPI0513119A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58781604P 2004-07-14 2004-07-14
PCT/US2005/024625 WO2006019716A1 (en) 2004-07-14 2005-07-12 Intracellular receptor modulator compounds and methods

Publications (1)

Publication Number Publication Date
BRPI0513119A true BRPI0513119A (pt) 2008-04-29

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Application Number Title Priority Date Filing Date
BRPI0513119-7A BRPI0513119A (pt) 2004-07-14 2005-07-12 compostos e métodos modulares de receptores intracelulares

Country Status (9)

Country Link
US (1) US20070254917A1 (pt)
EP (1) EP1778233A1 (pt)
JP (1) JP2008506689A (pt)
KR (1) KR20070056060A (pt)
CN (1) CN101018552A (pt)
BR (1) BRPI0513119A (pt)
CA (1) CA2581327A1 (pt)
MX (1) MX2007000449A (pt)
WO (1) WO2006019716A1 (pt)

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WO2008033757A2 (en) * 2006-09-11 2008-03-20 N.V. Organon 2-(1-oxo-1h-isoquinolin-2-yl) acetamide derivatives
US8008496B2 (en) * 2006-11-14 2011-08-30 Santen Pharmaceutical Co., Ltd. 1,2-dihydroquinoline derivative having substituted phenylchalcogeno lower alkyl group and ester-introduced phenyl group as substituents
TWI410422B (zh) * 2007-01-15 2013-10-01 Mitsubishi Tanabe Pharma Corp 縮合四氫喹啉衍生物及其醫藥用途
JP2008255112A (ja) * 2007-03-13 2008-10-23 Santen Pharmaceut Co Ltd ２，２，４−トリメチル−６−フェニル−１，２−ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト
WO2009103007A2 (en) * 2008-02-13 2009-08-20 Ligand Pharmaceuticals Incorporated Steroid hormone receptor modulator compounds and methods
KR20110010634A (ko) 2008-05-12 2011-02-01 산텐 세이야꾸 가부시키가이샤 치환 옥시기를 가지는 2,2,4-트리메틸-6-페닐-1,2-디하이드로퀴놀린 유도체를 포함하는 글루코코르티코이드 수용체 작용제
MX367404B (es) * 2014-06-30 2019-08-20 Astrazeneca Ab Amidas de benzoxazinona como moduladores del receptor de mineralocorticoides.
CN106220581B (zh) * 2016-07-06 2018-07-06 四川大学 含氟杂环化合物及其制备方法
TWI811400B (zh) 2018-07-20 2023-08-11 德商歌林達有限公司 經進一步取代之三唑并喹噁啉衍生物
IL280212B2 (en) * 2018-07-20 2023-09-01 Gruenenthal Chemie Transmuted triazoloquinoxaline histories
ES2980934T3 (es) 2019-01-22 2024-10-03 Akribes Biomedical Gmbh Modificadores selectivos del receptor de glucocorticoides para tratar la cicatrización alterada de heridas en la piel
IT201900017330A1 (it) * 2019-09-26 2021-03-26 Isagro Spa Processo per la preparazione di (r)-4-amminoindani e corrispondenti ammidi.

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