BRPI0513135A - bibliotecas de polinucleotìdeos, método de produção das mesmas, método de identificação de um polinucleotìdeo, região de ligação, meio adequado para uso em um, dispositivo eletrÈnico e dispositivo - Google Patents

bibliotecas de polinucleotìdeos, método de produção das mesmas, método de identificação de um polinucleotìdeo, região de ligação, meio adequado para uso em um, dispositivo eletrÈnico e dispositivo

Info

Publication number
BRPI0513135A
BRPI0513135A BRPI0513135-9A BRPI0513135A BRPI0513135A BR PI0513135 A BRPI0513135 A BR PI0513135A BR PI0513135 A BRPI0513135 A BR PI0513135A BR PI0513135 A BRPI0513135 A BR PI0513135A
Authority
BR
Brazil
Prior art keywords
libraries
polynucleotide
identifying
producing
electronic device
Prior art date
Application number
BRPI0513135-9A
Other languages
English (en)
Inventor
Roberto Crea
Original Assignee
Bioren Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioren Inc filed Critical Bioren Inc
Publication of BRPI0513135A publication Critical patent/BRPI0513135A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

BIBLIOTECAS DE POLINUCLEOTìDEOS, MéTODO DE PRODUçãO DAS MESMAS, MéTODO DE IDENTIFICAçãO DE UM POLINUCLEOTìDEO, REGIãO DE LIGAçãO, MEIO ADEQUADO PARA USO EM UM, DISPOSITIVO ELETRÈNICO E DISPOSITIVO. Bibliotecas de anticorpo universais são descritas as quais são sintéticas e derivadas das seqüências de anticorpo humanas expressas, selecionadas conseqüentemente por certos critérios, por exemplo, que as seqüências sejam derivadas de anticorpos de ocorrência natural expressos em resposta a uma certa classe de antígenos (por exemplo, molécula pequena, polissacarídeo, peptídeo ou proteína) e tendo regiões CDR planejadas com relação a diversidade ideal. São também apresentados métodos para a produção e triagem de tais bibliotecas para o isolamento de produtos terapêuticos para o tratamento de doenças.
BRPI0513135-9A 2004-07-06 2005-07-06 bibliotecas de polinucleotìdeos, método de produção das mesmas, método de identificação de um polinucleotìdeo, região de ligação, meio adequado para uso em um, dispositivo eletrÈnico e dispositivo BRPI0513135A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58593104P 2004-07-06 2004-07-06
PCT/US2005/024002 WO2006014498A2 (en) 2004-07-06 2005-07-06 Universal antibody libraries

Publications (1)

Publication Number Publication Date
BRPI0513135A true BRPI0513135A (pt) 2008-04-29

Family

ID=35787625

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513135-9A BRPI0513135A (pt) 2004-07-06 2005-07-06 bibliotecas de polinucleotìdeos, método de produção das mesmas, método de identificação de um polinucleotìdeo, região de ligação, meio adequado para uso em um, dispositivo eletrÈnico e dispositivo

Country Status (8)

Country Link
US (1) US11674240B2 (pt)
EP (1) EP1781680B8 (pt)
JP (1) JP5143551B2 (pt)
BR (1) BRPI0513135A (pt)
CA (1) CA2572961C (pt)
ES (1) ES2563491T3 (pt)
MX (1) MX2007000103A (pt)
WO (1) WO2006014498A2 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
EP2069558B1 (en) 2006-10-02 2013-05-01 Sea Lane Biotechnologies,llc. Design and construction of diverse synthetic peptide and polypeptide libraries
AU2014200954B2 (en) * 2006-10-02 2016-06-16 Bioassets, Llc Design and construction of diverse synthetic peptide and polypeptide libraries
BRPI0807952A2 (pt) * 2007-02-20 2014-06-10 Anaptysbio Inc Sistemas de hipermutação somática
EP2173772A2 (en) * 2007-07-03 2010-04-14 Ablynx N.V. Providing improved immunoglobulin sequences by mutating cdr and/or fr positions
EP2088432A1 (en) * 2008-02-11 2009-08-12 MorphoSys AG Methods for identification of an antibody or a target
SG175407A1 (en) 2009-05-29 2011-11-28 Morphosys Ag A collection and methods for its use
CA2772298A1 (en) * 2009-08-26 2011-03-03 Research Development Foundation Methods for creating antibody libraries
ES2826883T3 (es) 2009-10-14 2021-05-19 Janssen Biotech Inc Métodos de maduración por afinidad de anticuerpos
RU2603080C2 (ru) 2010-11-19 2016-11-20 МорфоСис АГ Коллекция и способы ее применения
TWI853985B (zh) * 2013-12-04 2024-09-01 日商中外製藥股份有限公司 因應化合物濃度使抗原結合能力變化的抗原結合分子及其資料庫
EP3246434A1 (en) * 2015-01-13 2017-11-22 Ewha University-Industry Collaboration Foundation Method for preparing novel antibody library and library prepared thereby
US10548987B2 (en) 2015-07-31 2020-02-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody-drug conjugates for targeting CD56-positive tumors
EP3293293A1 (en) * 2016-09-08 2018-03-14 Italfarmaco SpA Hc-cdr3-only libraries with reduced combinatorial redundancy and optimized loop length distribution
US11034951B2 (en) 2017-11-20 2021-06-15 Nantbio, Inc. mRNA display antibody library and methods
IL274780B2 (en) * 2017-11-20 2025-04-01 Nantbio Inc mRNA library for antibody display and methods
KR102115300B1 (ko) * 2018-06-01 2020-05-26 재단법인 목암생명과학연구소 항체 라이브러리 및 이를 이용한 항체 스크리닝 방법
CN113366104B (zh) * 2019-01-31 2024-03-26 南特生物科学公司 mRNA展示抗体文库和方法
WO2021115468A1 (zh) * 2019-12-13 2021-06-17 南京金斯瑞生物科技有限公司 一种构建抗体互补决定区文库的方法
IL297553A (en) * 2020-04-24 2022-12-01 Memorial Sloan Kettering Cancer Center Chimeric antigen receptors targeting cd19 and their use
WO2021231237A2 (en) * 2020-05-11 2021-11-18 Augmenta Bioworks, Inc. Antibodies for sars-cov-2 and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2078518T3 (es) 1990-04-05 1995-12-16 Roberto Crea Mutagenesis por desplazamiento completo.
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
CA2111858A1 (en) * 1991-07-15 1993-02-04 James S. Crowe Production of antibodies
ES2136092T3 (es) * 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US20030036092A1 (en) 1991-11-15 2003-02-20 Board Of Regents, The University Of Texas System Directed evolution of enzymes and antibodies
US5866344A (en) 1991-11-15 1999-02-02 Board Of Regents, The University Of Texas System Antibody selection methods using cell surface expressed libraries
US5667988A (en) 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US20030194807A1 (en) 1992-11-02 2003-10-16 Roberto Crea Walk-through mutagenesis
US5922545A (en) 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
AU725609C (en) 1995-08-18 2002-01-03 Morphosys Ag Protein/(poly)peptide libraries
US6352842B1 (en) * 1995-12-07 2002-03-05 Diversa Corporation Exonucease-mediated gene assembly in directed evolution
ES2430857T3 (es) 2000-12-18 2013-11-22 Dyax Corp. Bibliotecas focalizadas de paquetes genéticos
CA2443862A1 (en) * 2001-04-17 2002-10-24 Peizhi Luo Structure-based construction of human antibody library
US7117096B2 (en) 2001-04-17 2006-10-03 Abmaxis, Inc. Structure-based selection and affinity maturation of antibody library
DE60328674D1 (de) 2002-04-17 2009-09-17 Bioren Inc Universelle banken für immunoglobuline
EP1495142B1 (en) 2002-04-17 2007-09-26 Bioren, Inc. "doping" in walk-through mutagenesis
AU2004254352A1 (en) 2003-06-27 2005-01-13 Roberto Crea Look-through mutagenesis

Also Published As

Publication number Publication date
EP1781680B8 (en) 2016-05-18
US20110245108A1 (en) 2011-10-06
JP5143551B2 (ja) 2013-02-13
CA2572961C (en) 2016-08-16
EP1781680A4 (en) 2008-04-02
WO2006014498A2 (en) 2006-02-09
MX2007000103A (es) 2007-05-11
EP1781680B1 (en) 2016-01-20
ES2563491T3 (es) 2016-03-15
JP2008536473A (ja) 2008-09-11
EP1781680A2 (en) 2007-05-09
CA2572961A1 (en) 2006-02-09
WO2006014498A3 (en) 2007-03-01
US11674240B2 (en) 2023-06-13

Similar Documents

Publication Publication Date Title
BRPI0513135A (pt) bibliotecas de polinucleotìdeos, método de produção das mesmas, método de identificação de um polinucleotìdeo, região de ligação, meio adequado para uso em um, dispositivo eletrÈnico e dispositivo
DE60224291D1 (de) System zur antikörperexpression und- synthese
MX2009013824A (es) Proteinas de enlace de antigeno que enlazan par-2.
WO2003092630A3 (en) Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries
MX2008009886A (es) Anticuerpos que enlazan par-2.
PT2305715T (pt) Anticorpo monoclonal para a proteína de ligação a osteoprotegerina
WO2003078600A3 (en) Human monoclonal antibodies to influenza m2 protein and methods of making and using same
BRPI0519775A2 (pt) proteÍna isolada de ligaÇço a antÍgeno, polinucleotÍdeo isolado, plasmÍdio e cÉlula isolada e composiÇço farmacÊutica
MY163032A (en) Human anti-il-23 antibodies, compositions, methods and uses
TW200510459A (en) RG1 antibodies and uses thereof
MX348154B (es) Anticuerpos de enlace a il-1-beta y fragmentos de los mismos.
BR0315161A (pt) Anticorpo isolado, polinicleotìdeo isolado, vetor, célula hospedeira, método de produzir um anticorpo, e, composição
WO2004033631A8 (en) Nucleic acid and polypeptide sequences from lawsonia intracellularis and methods of using
BRPI0411854A (pt) veìculos protéicos para vacinas
TW200626614A (en) Human monoclonal antibodies to influenza M2 protein and methods of making and using same
WO2004029072A3 (en) PrPsc -INTERACTING MOLECULES AND USES THEREOF
EP2293079A3 (en) Use of precursors of enkephalins and/or their fragments in medical diagnostics
WO2007050095A3 (en) Improved vaccines and methods for using the same
WO2004069860A3 (en) Isg15-conjugated proteins
WO2003073351A3 (en) Screening process
WO2001025432A3 (en) Histamine receptor
DE50307968D1 (de) Antikörper zur isolierung und/oder identifizierung mesenchymaler stammzellen und verfahren zur isolierung und/oder identifizierung mesenchymaler stammzellen
WO1998025956A3 (en) Human GTP-binding proteins
DK1208213T3 (da) Fremgangsmåde til fremstilling af proteiner i værtsceller under anvendelse af chaperoniner
WO2004053142A3 (en) P53-associated parkin-like cytoplasmic protein, and related compositions and methods

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07H 21/02 , C07H 21/00 , C12P 19/34 , C07K 1/00

Ipc: C07K 16/00 (2006.01)

B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL