BRPI0514319A - composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para reduzir a condutáncia de cálcio de um receptor de capsaicina celular, e para inibir a ligação de ligando de vanilóide a um receptor de capsaicina, método para tratar uma condição respondente a modulação do receptor de capsaicina, dor, coceira, tosse ou soluço e incontinência urinária ou bexiga superativa em um paciente, métodos para promover perda de peso em um paciente obeso, para identificar um agente que liga ao receptor de capsaicina, e para determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica acondicionada, e, uso do composto ou sal - Google Patents
composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para reduzir a condutáncia de cálcio de um receptor de capsaicina celular, e para inibir a ligação de ligando de vanilóide a um receptor de capsaicina, método para tratar uma condição respondente a modulação do receptor de capsaicina, dor, coceira, tosse ou soluço e incontinência urinária ou bexiga superativa em um paciente, métodos para promover perda de peso em um paciente obeso, para identificar um agente que liga ao receptor de capsaicina, e para determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica acondicionada, e, uso do composto ou salInfo
- Publication number
- BRPI0514319A BRPI0514319A BRPI0514319-5A BRPI0514319A BRPI0514319A BR PI0514319 A BRPI0514319 A BR PI0514319A BR PI0514319 A BRPI0514319 A BR PI0514319A BR PI0514319 A BRPI0514319 A BR PI0514319A
- Authority
- BR
- Brazil
- Prior art keywords
- receptor
- capsaicin
- methods
- capsaicin receptor
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 150000001875 compounds Chemical class 0.000 title abstract 6
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 title abstract 5
- 102000005962 receptors Human genes 0.000 title abstract 5
- 108020003175 receptors Proteins 0.000 title abstract 5
- 150000003839 salts Chemical class 0.000 title abstract 4
- 229960002504 capsaicin Drugs 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title abstract 2
- 208000002193 Pain Diseases 0.000 title abstract 2
- 208000003251 Pruritus Diseases 0.000 title abstract 2
- 206010046543 Urinary incontinence Diseases 0.000 title abstract 2
- 229910052791 calcium Inorganic materials 0.000 title abstract 2
- 239000011575 calcium Substances 0.000 title abstract 2
- 235000017663 capsaicin Nutrition 0.000 title abstract 2
- 230000007803 itching Effects 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 102000011040 TRPV Cation Channels Human genes 0.000 title 4
- 108010062740 TRPV Cation Channels Proteins 0.000 title 4
- 206010011224 Cough Diseases 0.000 title 1
- 208000031361 Hiccup Diseases 0.000 title 1
- 206010020853 Hypertonic bladder Diseases 0.000 title 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 title 1
- 239000011230 binding agent Substances 0.000 title 1
- 230000001413 cellular effect Effects 0.000 title 1
- 230000001143 conditioned effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 208000020629 overactive bladder Diseases 0.000 title 1
- 230000004580 weight loss Effects 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- -1 biaryl piperazinyl pyridine analogs Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 208000020442 loss of weight Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
COMPOSTO OU SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO COMPOSIçãO FARMACêUTICA MéTODOS PARA REDUZIR A CONDUTáNCIA DE CáLCIO DE UM RECEPTOR DE CAPSAICINA CELULAR, E PARA INIBIR A LIGAçãO DE LIGANDO DE VANILóIDE A UM RECEPTOR DE CAPSAICINA, MéTODO PARA TRATAR UMA CONDIçãO RESPONDENTE A MODULAçãO DO RECEPTOR DE CAPSAICINA, DOR, COCEIRA, TOSSE OU SOLUçO E INCONTINêNCIA URINáRIA OU BEXIGA SUPERATIVA EM UM PACIENTE, MéTODOS PARA PROMOVER PERDA DE PESO EM UM PACIENTE OBESO, PARA IDENTIFICAR UM AGENTE QUE LIGA AO RECEPTOR DE CAPSAICINA, E PARA DETERMINAR A PRESENçA OU AUSêNCIA DE RECEPTOR DE CAPSAICINA EM UMA AMOSTRA, PREPARAçãO FARMACêUTICA ACONDICIONADA, E, USO DO COMPOSTO OU SAL Análogos de biaril piperazinil-piridina substituídos são providos de fórmula (I): em que as variáveis são como aqui descritas. Estes compostos são ligandos que podem ser usados para modular a atividade de receptor específica in vivo ou in vitro, e são particularmente utilizáveis no tratamento de condições associadas com a ativação de receptor patológico em humanos, animais de estimação domesticados e animais de criação. As composições farmacêuticas e métodos para usar estes compostos para tratar estes distúrbios são providos, assim como os métodos para usar estes ligandos para os estudos de localização de receptor.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60172104P | 2004-08-13 | 2004-08-13 | |
| US64179605P | 2005-01-05 | 2005-01-05 | |
| PCT/US2005/028969 WO2006026135A2 (en) | 2004-08-13 | 2005-08-13 | Substituted biaryl piperazinyl-pyridine analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0514319A true BRPI0514319A (pt) | 2008-06-10 |
Family
ID=36000525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0514319-5A BRPI0514319A (pt) | 2004-08-13 | 2005-08-13 | composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para reduzir a condutáncia de cálcio de um receptor de capsaicina celular, e para inibir a ligação de ligando de vanilóide a um receptor de capsaicina, método para tratar uma condição respondente a modulação do receptor de capsaicina, dor, coceira, tosse ou soluço e incontinência urinária ou bexiga superativa em um paciente, métodos para promover perda de peso em um paciente obeso, para identificar um agente que liga ao receptor de capsaicina, e para determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica acondicionada, e, uso do composto ou sal |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7662830B2 (pt) |
| EP (1) | EP1786800B1 (pt) |
| JP (1) | JP4955554B2 (pt) |
| KR (1) | KR20070046924A (pt) |
| CN (1) | CN101014587B (pt) |
| AR (1) | AR050194A1 (pt) |
| BR (1) | BRPI0514319A (pt) |
| CA (1) | CA2577301C (pt) |
| CR (1) | CR8992A (pt) |
| EC (1) | ECSP077318A (pt) |
| HN (1) | HN2007006799A (pt) |
| IL (1) | IL181040A0 (pt) |
| MA (1) | MA28857B1 (pt) |
| MX (1) | MX2007001696A (pt) |
| MY (1) | MY145822A (pt) |
| NI (1) | NI200700040A (pt) |
| NO (1) | NO20071243L (pt) |
| NZ (1) | NZ553388A (pt) |
| PE (1) | PE20060620A1 (pt) |
| RU (1) | RU2413726C2 (pt) |
| SG (1) | SG157399A1 (pt) |
| TW (1) | TW200605889A (pt) |
| WO (1) | WO2006026135A2 (pt) |
| ZA (1) | ZA200701530B (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2264014A1 (en) | 2001-08-31 | 2010-12-22 | Université Louis Pasteur | Substituted pyridazines as anti-inflammatory agents and protein kinase inhibitors |
| CA2531619A1 (en) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| MY145822A (en) * | 2004-08-13 | 2012-04-30 | Neurogen Corp | Substituted biaryl piperazinyl-pyridine analogues |
| JP2008518955A (ja) | 2004-11-02 | 2008-06-05 | ノースウェスタン ユニバーシティ | ピリダジン化合物および方法 |
| CA2589106C (en) | 2004-11-02 | 2015-07-21 | Northwestern University | Pyridazine compounds, compositions and methods and their use in treating inflammatory diseases |
| WO2006065872A1 (en) * | 2004-12-13 | 2006-06-22 | Neurogen Corporation | Piperazinyl-pyridine analogues |
| WO2006078992A2 (en) * | 2005-01-19 | 2006-07-27 | Neurogen Corporation | Heteroaryl substituted piperazinyl-pyridine analogues |
| AU2007243280A1 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Formulations containing pyridazine compounds for treating neuroinflammatory diseases |
| US8158627B2 (en) | 2006-04-28 | 2012-04-17 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
| US20080153845A1 (en) * | 2006-10-27 | 2008-06-26 | Redpoint Bio Corporation | Trpv1 antagonists and uses thereof |
| CA2685266C (en) * | 2007-04-27 | 2014-01-28 | Purdue Pharma L.P. | Trpv1 antagonists and uses thereof for the treatment of prevention of pain, ui and ulcer, ibd, or ibs in an animal |
| US8343966B2 (en) * | 2008-01-11 | 2013-01-01 | Novartis Ag | Organic compounds |
| CA2829558A1 (en) * | 2011-03-09 | 2012-09-13 | Celgene Avilomics Research, Inc. | Pi3 kinase inhibitors and uses thereof |
| ES2390326B1 (es) * | 2011-04-05 | 2013-08-14 | Universidad Miguel Hernández De Elche | Antagonistas de trpv1 y sus usos. |
| BR112014007310A2 (pt) | 2011-09-27 | 2017-04-04 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante |
| EP2785690B1 (en) * | 2011-12-02 | 2016-07-13 | Boehringer Ingelheim International GmbH | Piperidine derivatives, pharmaceutical compositions and uses thereof |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| JP6387360B2 (ja) | 2013-03-14 | 2018-09-05 | ノバルティス アーゲー | 変異ｉｄｈの阻害薬としての３−ピリミジン−４−イル−オキサゾリジン−２−オン |
| ES2724577T3 (es) | 2013-07-30 | 2019-09-12 | Janssen Sciences Ireland Unlimited Co | Análogos de piridina-piperazinilo sustituidos como compuestos antivirales de RSV |
| CN115060832B (zh) * | 2022-08-18 | 2022-11-29 | 上海奥科达生物医药科技有限公司 | 奥卡西平口服混悬液中奥卡西平及防腐剂含量检测方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS4921148B1 (pt) | 1970-12-28 | 1974-05-30 | ||
| US3775326A (en) | 1972-04-17 | 1973-11-27 | Addressograph Multigraph | Pressure fixable electroscopic printing powder |
| FR2262512A1 (en) | 1974-03-01 | 1975-09-26 | Synthelabo | 2,4,6-Tri-substd. -1,3,5-triazines - with analgesic and psychotropic activity |
| DE2643753A1 (de) * | 1976-09-29 | 1978-04-06 | Thomae Gmbh Dr K | Neue 1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine |
| FI70411C (fi) * | 1980-12-29 | 1986-09-19 | Pfizer | Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat |
| DE3609596A1 (de) * | 1986-03-21 | 1987-10-01 | Hoechst Ag | 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| GB9012311D0 (en) | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
| KR930702312A (ko) * | 1990-08-31 | 1993-09-08 | 아만 히데아키 | 피리미딘 유도체 및 의약 |
| KR970704444A (ko) | 1994-08-08 | 1997-09-06 | 아만 히데아키 | 트리아진 유도체 및 의약(triazine derivative and medicine) |
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| TW520362B (en) | 1996-12-05 | 2003-02-11 | Amgen Inc | Substituted pyrimidine compounds and pharmaceutical composition comprising same |
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