BRPI0514632A - substituted 4-heteroarylmethyl phthalazinone derivatives - Google Patents

substituted 4-heteroarylmethyl phthalazinone derivatives

Info

Publication number
BRPI0514632A
BRPI0514632A BRPI0514632-1A BRPI0514632A BRPI0514632A BR PI0514632 A BRPI0514632 A BR PI0514632A BR PI0514632 A BRPI0514632 A BR PI0514632A BR PI0514632 A BRPI0514632 A BR PI0514632A
Authority
BR
Brazil
Prior art keywords
optionally substituted
heteroarylmethyl
alkyl
group
substituted
Prior art date
Application number
BRPI0514632-1A
Other languages
Portuguese (pt)
Inventor
Muhammad Hasmim Javaid
Graeme Cameron Murray Smith
Niall Morrison Barr Martin
Sylvie Gomez
Vincent Ming Lai Junior Loh
Xiao-Ling Fan Cockcroft
Stefano Forte
Keith Allan Menear
Ian Timothy Williams Matthews
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0419072.4A external-priority patent/GB0419072D0/en
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of BRPI0514632A publication Critical patent/BRPI0514632A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE FTALAZINONA 4-HETEROARILMETILA SUBSTITUìDOS Composto da fórmula (I): para uso no tratamento de câncer ou de outras doenças melhoradas pela inibição de PARP, em que: A e B em conjunto representam um anel aromático fundido opcionalmente substituído; X pode ser NR¬ x¬ ou CR¬ x¬R¬ y¬; se X = NR¬ x¬ então n é 1 ou 2 e se x = CR¬ x¬R¬ y¬ então n é 1; R¬ x¬ é selecionado do grupo que consiste em H, grupos alquila C~ 1-20~, arila C~ 5-20~, heterociclila C~ 3-20~, amido, tioamido, éster, acila, e sulfonila opcionalmente substituídos; R¬ y¬ é selecionado de H, hidróxi, amino; ou então R¬ x¬ e R¬ y¬~ podem formar em conjunto um grupo cicloalquila ou heterociclila espiro-C~ 3-7~; R¬ C1¬ e R¬ C2¬ são independentemente selecionados do grupo que consiste em hidrogênio e alquila C~ 1~-~ 4~, ou quando X for CR¬ x¬R¬ y¬, R¬ C1¬, R¬ C2¬, R¬ x¬ e R¬ y¬, juntamente com os átomos de carbono aos quais eles estão ligados, poderão formar um anel aromático fundido opcionalmente substituído; R¬ 1¬ é selecionado de H e halo; e Het é selecionado de: (i) fórmula (i) em que Y¬ 1¬ é selecionado de CH e N, Y¬ 2¬ é selecionado de CH e N, Y¬ 3¬ é selecionado de CH, CF e N, sendo que somente um ou dois de Y¬ 1¬, Y¬ 2¬ e Y¬ 3¬ podem ser N; e (ii), em que Q é O ou S.SUBSTITUTED 4-HETEROARYLMETHYL FTAAZINONE DERIVATIVES Compound of formula (I): for use in the treatment of cancer or other diseases enhanced by PARP inhibition, wherein: A and B together represent an optionally substituted fused aromatic ring; X may be NR¬ x¬ or CR¬ x¬R¬ y¬; if X = NR¬ x¬ then n is 1 or 2 and if x = CR¬ x¬R¬ y¬ then n is 1; R¬ x¬ is selected from the group consisting of optionally substituted H, C 1-20 alkyl alkyl, C 5-20 aryl, C 3-20 heterocyclyl, starch, thioamido, ester, acyl and sulfonyl groups ; R¬ y¬ is selected from H, hydroxy, amino; or R¬x¬ and R¬y¬ may together form a C 3-7 spiro-cycloalkyl or heterocyclyl group; R¬ C1¬ and R¬ C2¬ are independently selected from the group consisting of hydrogen and alkyl C ~ 1 ~ - ~ 4 ~, or when X is CR¬ x¬R¬ y¬, R¬ C1¬, R¬ C2 ¬, R¬ x¬ and R¬ y¬, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; R¬ 1¬ is selected from H and halo; and Het is selected from: (i) formula (i) wherein Y¬ 1¬ is selected from CH and N, Y¬ 2¬ is selected from CH and N, Y¬ 3¬ is selected from CH, CF and N, whereas only one or two of Y¬ 1¬, Y¬ 2¬ and Y¬ 3¬ can be N; and (ii) where Q is O or S.

BRPI0514632-1A 2004-08-26 2005-08-26 substituted 4-heteroarylmethyl phthalazinone derivatives BRPI0514632A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0419072.4A GB0419072D0 (en) 2004-08-26 2004-08-26 Phthalazinone derivatives
US60495604P 2004-08-27 2004-08-27
PCT/GB2005/003343 WO2006021801A1 (en) 2004-08-26 2005-08-26 4-heteroarylmethyl substituted phthalazinone derivatives

Publications (1)

Publication Number Publication Date
BRPI0514632A true BRPI0514632A (en) 2008-06-17

Family

ID=35219560

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514632-1A BRPI0514632A (en) 2004-08-26 2005-08-26 substituted 4-heteroarylmethyl phthalazinone derivatives

Country Status (11)

Country Link
EP (1) EP1791827A1 (en)
JP (1) JP2008510783A (en)
KR (1) KR20070057859A (en)
AU (1) AU2005276229A1 (en)
BR (1) BRPI0514632A (en)
CA (1) CA2577191A1 (en)
IL (1) IL181408A0 (en)
MX (1) MX2007002318A (en)
NO (1) NO20071579L (en)
NZ (1) NZ553979A (en)
WO (1) WO2006021801A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0521373D0 (en) * 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
US7834015B2 (en) 2006-05-31 2010-11-16 Instituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Pyrrolo[1,2-a] pyrazin-1(2H)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP)
GB0610680D0 (en) 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
EA016079B1 (en) 2007-01-10 2012-01-30 Институто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти Спа Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
WO2008145681A2 (en) 2007-05-31 2008-12-04 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
GB0716532D0 (en) 2007-08-24 2007-10-03 Angeletti P Ist Richerche Bio Therapeutic compounds
AU2008299721A1 (en) * 2007-09-14 2009-03-19 Astrazeneca Ab Phthalazinone derivatives
WO2009063244A1 (en) 2007-11-15 2009-05-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Pyridazinone derivatives as parp inhibitors
AR070221A1 (en) * 2008-01-23 2010-03-25 Astrazeneca Ab DERIVATIVES OF FTALAZINONA POLYMERASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES OF THE SAME TO PREVENT AND / OR TREAT CANCERIGENE TUMORS, ISCHEMICAL INJURIES AND OTHER ASSOCIATED DISEASES.
GB0804755D0 (en) 2008-03-14 2008-04-16 Angeletti P Ist Richerche Bio Therapeutic compounds
DK2379525T3 (en) * 2008-12-19 2015-10-19 Boehringer Ingelheim Int Cyclic pyrimidin-4-carboxamides, as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
WO2011073154A1 (en) 2009-12-17 2011-06-23 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists and uses thereof
EP2569295B1 (en) 2010-05-12 2014-11-19 Boehringer Ingelheim International GmbH New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8877745B2 (en) 2010-05-12 2014-11-04 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
EP2576538B1 (en) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH New CCR2 antagonists
JP2013532683A (en) 2010-07-27 2013-08-19 カディラ ヘルスケア リミティド Substituted 4- (4-fluoro-3- (piperazin-1-carbonyl) benzyl) phthalazin-1 (2H) -one derivatives as poly (ADP ribose) polymerase-1 inhibitors
CN102372716A (en) 2010-08-09 2012-03-14 江苏恒瑞医药股份有限公司 Phthalazone derivative, its preparation method and application in medicine thereof
KR101242572B1 (en) * 2010-10-12 2013-03-19 한국화학연구원 Phthalazinone derivatives substituted 5-membered heterocyclic aryl, or pharmaceutically acceptable salts thereof, preparation method therof and pharmaceutical composition
JP5699223B2 (en) * 2010-12-02 2015-04-08 シャンハイ デュァ ノボ ファルマテック カンパニー リミテッド Heterocyclic derivatives, their synthesis and medical applications
EP2686305B1 (en) * 2011-03-14 2020-09-16 Impact Therapeutics, Inc. Quinazolinediones and their use
EP3925962A1 (en) 2011-05-31 2021-12-22 Rakovina Therapeutics Inc. Tricyclic inhibitors of poly(adp-ribose) polymerase
JP5786258B2 (en) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel and selective CCR2 antagonist
CN103130723B (en) 2011-11-30 2015-01-14 成都地奥制药集团有限公司 Poly (aenosine diphosphate glucose pyrophospheralase (ADP)-ribose) polymerase inhibitor
CN102964354B (en) * 2012-11-16 2014-08-13 江苏先声药业有限公司 Thienoimidazole-like derivatives and applications thereof
CN102977040B (en) * 2012-11-20 2015-06-03 浙江工业大学 Method for synthesizing 2-quinoxalinyl dimethylacetal and 2-quinoxalinyl formaldehyde
DK2938598T3 (en) 2012-12-31 2017-02-13 Cadila Healthcare Ltd Substituted phthalazine-1 (2H) -one derivatives as selective inhibitors of poly (adp-ribose) polymerase-1
HRP20191860T1 (en) 2013-03-13 2019-12-27 Forma Therapeutics, Inc. 2-hydroxy-1-{4-[(4-phenylphenyl)carbonyl]piperazin-1-yl}ethan-1-one derivatives and related compounds as fatty acid synthase (fasn) inhibitors for the treatment of cancer
CN106146492A (en) * 2015-04-17 2016-11-23 上海汇伦生命科技有限公司 Heterocycle glyoxaline compound, its pharmaceutical composition and its production and use
WO2017004537A1 (en) 2015-07-02 2017-01-05 Centrexion Therapeutics Corporation (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
CN105384684B (en) * 2015-12-16 2018-02-13 辽宁工程技术大学 A kind of preparation method of the picoline of 2 cyano group 6
CA3129516A1 (en) 2018-02-28 2019-09-06 The Trustees Of The University Of Pennsylvania Low affinity poly(ad-ribose) polymerase 1 dependent cytotoxic agents
TWI767148B (en) 2018-10-10 2022-06-11 美商弗瑪治療公司 Inhibiting fatty acid synthase (fasn)
WO2020092395A1 (en) 2018-10-29 2020-05-07 Forma Therapeutics, Inc. SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE
US20220110936A1 (en) * 2019-02-02 2022-04-14 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Pharmaceutical composition for treatment of neurodegenerative diseases or diseases caused by abnormality of rna binding protein and applications thereof
HUE071067T2 (en) 2019-07-19 2025-07-28 Astrazeneca Ab Parp1 inhibitors
ES3014370T3 (en) 2020-04-28 2025-04-22 Rhizen Pharmaceuticals Ag Novel compounds useful as poly(adp-ribose) polymerase (parp) inhibitors
WO2022090938A1 (en) 2020-10-31 2022-05-05 Rhizen Pharmaceuticals Ag Phthalazinone derivatives useful as parp inhibitors
TW202304447A (en) 2021-04-08 2023-02-01 瑞士商瑞森製藥公司 Inhibitors of poly(adp-ribose) polymerase

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3813531A1 (en) * 1987-05-02 1988-11-10 Asta Pharma Ag Novel 2-aminoalkyl-4-benzyl-1-(2H)-phthalazinone derivatives
ZA882639B (en) * 1987-05-02 1988-09-30 Asta-Pharma Aktiengesellschaft New 2-aminoalkyl-4-benzyl-1(2h)-phthalazinone derivatives
CA2205757C (en) * 1996-05-30 2006-01-24 F. Hoffmann-La Roche Ag Pyridazinone derivatives and their use as inhibitors of prostaglandin g/h synthase i and ii(cox i and ii)
GB0026505D0 (en) * 2000-10-30 2000-12-13 Kudos Pharm Ltd Phthalazinone derivatives
AU9578901A (en) * 2000-10-30 2002-05-15 Kudos Pharm Ltd Phthalazinone derivatives
DE60218458T2 (en) * 2001-05-08 2007-11-15 Kudos Pharmaceuticals Ltd. ISOCHINOLINONE DERIVATIVES AS PARP INHIBITORS
US7402580B2 (en) * 2002-02-19 2008-07-22 Ono Pharmaceutical Co., Ltd. Fused pyridazine derivative compounds and drugs containing these compounds as the active ingredient
US7196085B2 (en) * 2002-04-30 2007-03-27 Kudos Pharmaceuticals Limited Phthalazinone derivatives
AU2004220321B2 (en) * 2003-03-12 2010-02-25 Kudos Pharmaceuticals Ltd Phthalazinone derivatives

Also Published As

Publication number Publication date
MX2007002318A (en) 2007-04-17
KR20070057859A (en) 2007-06-07
EP1791827A1 (en) 2007-06-06
WO2006021801A1 (en) 2006-03-02
NZ553979A (en) 2009-05-31
CA2577191A1 (en) 2006-03-02
NO20071579L (en) 2007-05-29
JP2008510783A (en) 2008-04-10
AU2005276229A1 (en) 2006-03-02
IL181408A0 (en) 2007-07-04

Similar Documents

Publication Publication Date Title
BRPI0408284A (en) phthalazinone derivatives
BRPI0718966B8 (en) compound, pharmaceutical composition, plk1 inhibitor and antitumor agent
BR9916566A (en) Ras-farnesyltransferase esulfobutylether-7-ß-cyclodextrin or 2-hydroxypropyl-ß-cyclodextrin inhibitor complex and process
BR9916781A (en) 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
BRPI0407082A (en) Compound, prodrug, pharmaceutical, method of antagonizing gonadotropin-releasing hormone, and use of the compound
UA99485C2 (en) Quinazolinedione derivatives, preparation thereof and therapeutic uses thereof
BR0115580A (en) 3-Aroylindole derivatives and their use as cb2 receptor agonists
BRPI0506719A (en) compound, pharmaceutical composition, and use of a compound
UA97794C2 (en) Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use
BRPI0413861A (en) pyrimidothiophene compounds
BRPI0407976A (en) 2,5 and 2,6-substituted tetrahydroisoquinolines for use as 5-ht6 modulators
DK1272477T3 (en) pyrimidine
BR0312069A (en) Benzimidazole compounds and their use as estrogen agonists / antagonists
JO2503B1 (en) Benzothiazole derivatives
BR9809598A (en) Use of compounds, and, compound.
BR0208805A (en) Use of a pyrazoline derivative
MA33721B1 (en) HETEROCYCLIC SULFONAMIDE DERIVATIVES AS MEK INHIBITORS
MX2009008386A (en) 2-amin0-5, 7-dihydr0-6h- pyrrolo [3, 4-d] pyrimidine derivatives as hsp-90 inhibitors for treating cancer.
BR0308145A (en) Compound, pharmaceutical composition, use of a compound, and process for preparing a compound
BRPI0413467A (en) aminopyrones and their use as inhibitors of atm
BR0311315A (en) Aromatic sulphones and their medical use
BR0209936A (en) Pharmaceutical combined composition, and use of a cyanoguanidine ikk compound and inhibitor
AU2006232435A8 (en) BCRP/ABCG2 inhibitor
BR0316785A (en) 4-Pyrimidone-3-substituted derivatives
BRPI0412862A (en) nicotinamide derivatives useful as pde4 inhibitors

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: KUDOS PHARMACEUTICALS LIMITED (GB) , MAYBRIDGE LIM

Free format text: TRANSFERIDO PARTE DOS DIREITOS DE: KUDOS PHARMACEUTICALS LIMITED

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 7A ANUIDADE.