BRPI0514735A - derivados de piridino sulfonamida como moduladores do receptor de quimiocina - Google Patents
derivados de piridino sulfonamida como moduladores do receptor de quimiocinaInfo
- Publication number
- BRPI0514735A BRPI0514735A BRPI0514735-2A BRPI0514735A BRPI0514735A BR PI0514735 A BRPI0514735 A BR PI0514735A BR PI0514735 A BRPI0514735 A BR PI0514735A BR PI0514735 A BRPI0514735 A BR PI0514735A
- Authority
- BR
- Brazil
- Prior art keywords
- receptor modulators
- sulfonamide derivatives
- pyridine sulfonamide
- chemokine receptor
- pyridine
- Prior art date
Links
- DWJMBQYORXLGAE-UHFFFAOYSA-N pyridine-2-sulfonamide Chemical class NS(=O)(=O)C1=CC=CC=N1 DWJMBQYORXLGAE-UHFFFAOYSA-N 0.000 title abstract 2
- 102000009410 Chemokine receptor Human genes 0.000 title 1
- 108050000299 Chemokine receptor Proteins 0.000 title 1
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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Abstract
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0419235.7 | 2004-08-28 | ||
| GB0419235A GB0419235D0 (en) | 2004-08-28 | 2004-08-28 | Compounds |
| GB0502544.0 | 2005-02-08 | ||
| GB0502544A GB0502544D0 (en) | 2005-02-08 | 2005-02-08 | Compounds |
| PCT/GB2005/003257 WO2006024823A1 (en) | 2004-08-28 | 2005-08-23 | Pyrimidine sulphonamide derivatives as chemokine receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0514735A true BRPI0514735A (pt) | 2008-06-24 |
| BRPI0514735B1 BRPI0514735B1 (pt) | 2020-08-11 |
| BRPI0514735B8 BRPI0514735B8 (pt) | 2021-05-25 |
Family
ID=35549576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0514735A BRPI0514735B8 (pt) | 2004-08-28 | 2005-08-23 | derivados de pirimidino sulfonamida como moduladores do receptor de quimiocina. |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US7838675B2 (pt) |
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| RU (1) | RU2408587C2 (pt) |
| SI (1) | SI1809624T1 (pt) |
| TW (1) | TWI369983B (pt) |
| UY (1) | UY29085A1 (pt) |
| WO (1) | WO2006024823A1 (pt) |
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| JPS6262286A (ja) * | 1985-09-13 | 1987-03-18 | 株式会社東芝 | 沸騰水型原子炉炉心 |
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| AU2005279045B2 (en) | 2004-08-28 | 2009-11-26 | Astrazeneca Ab | Pyrimidine sulphonamide derivatives as chemokine receptor modulators |
| US7786137B2 (en) * | 2005-05-10 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of ion channels |
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| US20100137398A1 (en) * | 2007-05-04 | 2010-06-03 | Novartis Ag | Use of hdac inhibitors for the treatment of gastrointestinal cancers |
| WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
| CA2730477A1 (en) * | 2008-07-16 | 2010-01-21 | Astrazeneca Ab | Pyrimidyl sulfonaminde derivative and its use for the treatment of chemokine mediated diseases |
| CA2762680C (en) | 2009-05-21 | 2018-04-17 | Chlorion Pharma, Inc. | Methyl sulfanyl pyrmidmes useful as antiinflammatories, analgesics, and antiepileptics |
| AR080375A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida |
| WO2012007748A1 (en) * | 2010-07-13 | 2012-01-19 | Astrazeneca Ab | New crystalline forms of n-[2-[[(2,3-difluoropheny)methyl)thio]-6-{[(1r,2s)-2,3-dihydroxy-1- methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide |
| WO2013008002A1 (en) | 2011-07-12 | 2013-01-17 | Astrazeneca Ab | N- (6- ( (2r,3s) -3,4-dihydroxybutan-2-yloxy) -2- (4 - fluorobenzylthio) pyrimidin- 4 - yl) -3- methylazetidine- 1 - sulfonamide as chemokine receptor modulator |
| TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
| PT3263133T (pt) | 2015-02-27 | 2020-05-21 | Univ Kyushu Nat Univ Corp | Composto de piridinona e a sua utilização |
| CN109152780B (zh) * | 2016-03-11 | 2021-10-01 | 阿迪亚生命科学公司 | 用于治疗结晶性关节病症的cxcr-2抑制剂 |
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| US3457278A (en) * | 1964-10-15 | 1969-07-22 | Geigy Chem Corp | Cyclopropyl-4-sulfanilamido-pyrimidines |
| US3452018A (en) * | 1966-08-29 | 1969-06-24 | American Home Prod | 1 - (2 - substituted - 6 - arylsulfonamidopyrimidin - 4 - yl)pyridinium hydroxide inner salts |
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2005
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- 2005-08-23 CN CN201210247005.5A patent/CN102796081B/zh not_active Expired - Lifetime
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- 2005-08-23 EP EP10194616A patent/EP2301933A1/en not_active Withdrawn
- 2005-08-23 WO PCT/GB2005/003257 patent/WO2006024823A1/en not_active Ceased
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- 2005-08-23 US US11/574,340 patent/US7838675B2/en active Active
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- 2005-08-26 UY UY29085A patent/UY29085A1/es not_active Application Discontinuation
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- 2011-01-26 JP JP2011013745A patent/JP5364735B2/ja not_active Expired - Lifetime
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