BRPI0515125A - conjugados de polissacarìdeo derivatizado-proteìna multivalentes, meningocócicos e vacina - Google Patents
conjugados de polissacarìdeo derivatizado-proteìna multivalentes, meningocócicos e vacinaInfo
- Publication number
- BRPI0515125A BRPI0515125A BRPI0515125-2A BRPI0515125A BRPI0515125A BR PI0515125 A BRPI0515125 A BR PI0515125A BR PI0515125 A BRPI0515125 A BR PI0515125A BR PI0515125 A BRPI0515125 A BR PI0515125A
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- derivatized
- conjugates
- vaccine
- polysaccharide conjugates
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title abstract 5
- 229920001282 polysaccharide Polymers 0.000 title abstract 5
- 239000005017 polysaccharide Substances 0.000 title abstract 5
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 241000588650 Neisseria meningitidis Species 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
CONJUGADOS DE POLISSACARìDEO DERIVATIZADO-PROTEìNA MULTIVALENTES, MENINGOCóCICOS E VACINA. A presente invenção refere-se a conjugados de polissacarídeo derivatizado-proteína, uma composição compreendendo um ou mais de tais conjugados de polissacarídeo derivatizado e métodos para imunização de pacientes humanos com os mesmos. Os conjugados de polissacarídeo derivatizado-proteína são polissacarídeos capsulares purificados dos sorogrupos de Neisseria meningitidis A, C, W-135 e Y, derivatizados, ativados químicamente e anexados seletivamente a uma proteína veículo por meio de uma ligação química covalente, formando conjugados de polissacarídeo-proteína capazes de promover a imunidade de longa duração contra várias cepas de N. meningitidis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60557904P | 2004-08-30 | 2004-08-30 | |
| PCT/US2005/031034 WO2006026689A2 (en) | 2004-08-30 | 2005-08-29 | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0515125A true BRPI0515125A (pt) | 2008-07-08 |
Family
ID=36000720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0515125-2A BRPI0515125A (pt) | 2004-08-30 | 2005-08-29 | conjugados de polissacarìdeo derivatizado-proteìna multivalentes, meningocócicos e vacina |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060088554A1 (pt) |
| EP (2) | EP1784214A4 (pt) |
| JP (2) | JP2008517876A (pt) |
| KR (1) | KR20070101207A (pt) |
| CN (2) | CN101048177A (pt) |
| AU (1) | AU2005279821A1 (pt) |
| BR (1) | BRPI0515125A (pt) |
| CA (1) | CA2577920A1 (pt) |
| IL (1) | IL181551A0 (pt) |
| WO (1) | WO2006026689A2 (pt) |
| ZA (1) | ZA200701675B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008513541A (ja) * | 2004-09-21 | 2008-05-01 | サノフィ パストゥール インコーポレイテッド | 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| PL2004225T3 (pl) | 2006-03-22 | 2012-09-28 | Novartis Ag | Schematy immunizacji koniugatami meningokokowymi |
| US7491517B2 (en) * | 2006-07-19 | 2009-02-17 | Jeeri R Reddy | Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135 |
| WO2013046226A2 (en) * | 2011-08-04 | 2013-04-04 | Serum Institute Of India Ltd. | A novel quantification method for vaccines |
| CN103007268A (zh) * | 2012-12-26 | 2013-04-03 | 天津康希诺生物技术有限公司 | 一种低剂量多价结合疫苗组合物及用途 |
| CN103893751B (zh) * | 2014-03-26 | 2016-04-20 | 天津康希诺生物技术有限公司 | 一种肺炎球菌多糖蛋白缀合疫苗及其制备方法 |
| KR102906912B1 (ko) | 2016-09-02 | 2026-01-05 | 사노피 파스퇴르 인크 | 네이세리아 메닌기티디스 백신 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4619828A (en) | 1982-07-06 | 1986-10-28 | Connaught Laboratories, Inc. | Polysaccharide exotoxoid conjugate vaccines |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| US5422427A (en) | 1991-09-17 | 1995-06-06 | The United States Of America As Represented By The United States Department Of Health And Human Services | Pneumococcal fimbrial protein A |
| US5445817A (en) | 1992-08-21 | 1995-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines |
| US5965714A (en) * | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
| US6146902A (en) * | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| OA12590A (en) * | 2001-01-23 | 2006-06-08 | Aventis Pasteur | Multivalent meningococcal polysaccharide-protein conjugate vaccine. |
| AU2002309706A1 (en) * | 2001-05-11 | 2002-11-25 | Aventis Pasteur, Inc. | Novel meningitis conjugate vaccine |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| PT1777236T (pt) * | 2002-03-26 | 2017-02-13 | Glaxosmithkline Biologicals Sa | Sacáridos modificados possuindo estabilidade melhorada em água para utilização como um medicamento |
| CA2524853A1 (en) * | 2003-05-07 | 2005-01-20 | Aventis Pasteur, Inc. | Method of enhanced immunogenicity to meningococcal vaccination |
| CN1852733A (zh) * | 2003-05-07 | 2006-10-25 | 安万特巴斯德公司 | 多价脑膜炎球菌衍生的多糖－蛋白质缀合物及疫苗 |
| JP2008513541A (ja) * | 2004-09-21 | 2008-05-01 | サノフィ パストゥール インコーポレイテッド | 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン |
-
2005
- 2005-08-29 EP EP05806584A patent/EP1784214A4/en not_active Ceased
- 2005-08-29 BR BRPI0515125-2A patent/BRPI0515125A/pt not_active IP Right Cessation
- 2005-08-29 CN CNA200580037092XA patent/CN101048177A/zh active Pending
- 2005-08-29 AU AU2005279821A patent/AU2005279821A1/en not_active Abandoned
- 2005-08-29 EP EP10187955A patent/EP2351582A1/en not_active Withdrawn
- 2005-08-29 KR KR1020077007502A patent/KR20070101207A/ko not_active Ceased
- 2005-08-29 CA CA002577920A patent/CA2577920A1/en not_active Abandoned
- 2005-08-29 JP JP2007530326A patent/JP2008517876A/ja active Pending
- 2005-08-29 US US11/214,438 patent/US20060088554A1/en not_active Abandoned
- 2005-08-29 CN CN2010102067830A patent/CN101934077A/zh active Pending
- 2005-08-29 WO PCT/US2005/031034 patent/WO2006026689A2/en not_active Ceased
-
2007
- 2007-02-26 ZA ZA200701675A patent/ZA200701675B/xx unknown
- 2007-02-26 IL IL181551A patent/IL181551A0/en unknown
-
2012
- 2012-04-06 JP JP2012087349A patent/JP2012140456A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101048177A (zh) | 2007-10-03 |
| JP2008517876A (ja) | 2008-05-29 |
| EP1784214A2 (en) | 2007-05-16 |
| EP1784214A4 (en) | 2009-09-23 |
| KR20070101207A (ko) | 2007-10-16 |
| JP2012140456A (ja) | 2012-07-26 |
| WO2006026689A2 (en) | 2006-03-09 |
| CN101934077A (zh) | 2011-01-05 |
| CA2577920A1 (en) | 2006-03-09 |
| AU2005279821A1 (en) | 2006-03-09 |
| ZA200701675B (en) | 2008-11-26 |
| US20060088554A1 (en) | 2006-04-27 |
| EP2351582A1 (en) | 2011-08-03 |
| WO2006026689A3 (en) | 2006-07-27 |
| IL181551A0 (en) | 2007-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2269 DE 01/07/2014. |