BRPI0515522A - composto, composição farmacêutica. métodos de inibir a ligação de ligandos endógenos ao receptor crth-2 em uma célula, de tratar, melhorar ou prevenir um distúrbio responsivo à inibição da ligação de ligandos endógenos ao receptor crth-2 em um animal e de preparar um composto, e, kit - Google Patents

composto, composição farmacêutica. métodos de inibir a ligação de ligandos endógenos ao receptor crth-2 em uma célula, de tratar, melhorar ou prevenir um distúrbio responsivo à inibição da ligação de ligandos endógenos ao receptor crth-2 em um animal e de preparar um composto, e, kit

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Publication number
BRPI0515522A
BRPI0515522A BRPI0515522-3A BRPI0515522A BRPI0515522A BR PI0515522 A BRPI0515522 A BR PI0515522A BR PI0515522 A BRPI0515522 A BR PI0515522A BR PI0515522 A BRPI0515522 A BR PI0515522A
Authority
BR
Brazil
Prior art keywords
receptor
crth
inhibiting
binding
compound
Prior art date
Application number
BRPI0515522-3A
Other languages
English (en)
Inventor
Youssef L Bennani
Lawrence N Tumey
Elizabeth Ann Gleason
Michael Joseph Robarge
Original Assignee
Athersys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athersys Inc filed Critical Athersys Inc
Publication of BRPI0515522A publication Critical patent/BRPI0515522A/pt

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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO DE INIBIR A LIGAçãO DE LIGANDOS ENDóGENOS AO RECEPTOR CRTH-2 EM UMA CéLULA, DE TRATAR, MELHORAR OU PREVENR UM DISTúRBIO RESPONSIVO à INIBIçãO DA LIGAçãO DE LIGANDOS ENDóGENOS AO RECEPTOR CRTH-2 EM UM ANIMAL E DE PREPARAR UM COMPOSTO, E, KIT". A invenção se refere a compostos de ácido benzimidazol acético que funcionam como antagonistas da molécula homóloga de receptor quimioatraente expressada em receptor de células T auxiliares do tipo 2 (CRTH2). A invenção também se refere ao uso desses compostos para inibir a ligação de protaglandina D ~2~ e seus metabólitos ou certos metabólitos de tromboxano ao receptor de CRTH2 e para tratar distúrbis em resposta a tal inibição.
BRPI0515522-3A 2004-09-21 2005-09-21 composto, composição farmacêutica. métodos de inibir a ligação de ligandos endógenos ao receptor crth-2 em uma célula, de tratar, melhorar ou prevenir um distúrbio responsivo à inibição da ligação de ligandos endógenos ao receptor crth-2 em um animal e de preparar um composto, e, kit BRPI0515522A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61129604P 2004-09-21 2004-09-21
PCT/US2005/034028 WO2006034418A2 (en) 2004-09-21 2005-09-21 Benzimidazole acetic acids exhibiting crth2 receptor antagonism and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0515522A true BRPI0515522A (pt) 2008-07-29

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Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515522-3A BRPI0515522A (pt) 2004-09-21 2005-09-21 composto, composição farmacêutica. métodos de inibir a ligação de ligandos endógenos ao receptor crth-2 em uma célula, de tratar, melhorar ou prevenir um distúrbio responsivo à inibição da ligação de ligandos endógenos ao receptor crth-2 em um animal e de preparar um composto, e, kit

Country Status (12)

Country Link
US (2) US7732618B2 (pt)
EP (1) EP1814865A4 (pt)
JP (1) JP2008513511A (pt)
KR (1) KR20070115865A (pt)
CN (1) CN101124207A (pt)
AU (1) AU2005286717A1 (pt)
BR (1) BRPI0515522A (pt)
CA (1) CA2581335A1 (pt)
EA (1) EA200700711A1 (pt)
IL (1) IL182103A0 (pt)
MX (1) MX2007003335A (pt)
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WO2006034418A3 (en) 2006-05-18
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WO2006034418A2 (en) 2006-03-30
KR20070115865A (ko) 2007-12-06
CA2581335A1 (en) 2006-03-30
EP1814865A4 (en) 2009-09-02
CN101124207A (zh) 2008-02-13
US20110105573A1 (en) 2011-05-05
US20060106081A1 (en) 2006-05-18
EP1814865A2 (en) 2007-08-08
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IL182103A0 (en) 2007-07-24
US7732618B2 (en) 2010-06-08

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