BRPI0515788A - alelos do gene gnd de bactérias corineformes - Google Patents

alelos do gene gnd de bactérias corineformes

Info

Publication number
BRPI0515788A
BRPI0515788A BRPI0515788-9A BRPI0515788A BRPI0515788A BR PI0515788 A BRPI0515788 A BR PI0515788A BR PI0515788 A BRPI0515788 A BR PI0515788A BR PI0515788 A BRPI0515788 A BR PI0515788A
Authority
BR
Brazil
Prior art keywords
coryneform bacteria
recombinant
microorganism
6pgdh
val
Prior art date
Application number
BRPI0515788-9A
Other languages
English (en)
Inventor
Georg Thierbach
Brigitte Bathe
Natalie Schischka
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of BRPI0515788A publication Critical patent/BRPI0515788A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"ALELOS DO GENE GND DE BACTéRIAS CORINEFORMES". A presente invenção refere-se a mutantes e alelos do gene gnd de bactérias corineformes que codificam para 6-fosfogliconato desidrogenase que contém na posição 329 ou em uma posição comparável da seqüência de aminoácidos qualquer aminoácido diferente de L-valina, e processar a produção de aminoácidos, preferivelmente L-lisina e L-triptofano, pela fermentação usando bactérias que contêm esses alelos.
BRPI0515788-9A 2004-12-18 2005-11-21 alelos do gene gnd de bactérias corineformes BRPI0515788A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004061015 2004-12-18
DE102005032426A DE102005032426A1 (de) 2004-12-18 2005-07-12 Allele des gnd-Gens aus coryneformen Bakterien
PCT/EP2005/012417 WO2006063660A1 (de) 2004-12-18 2005-11-21 Allele des gnd-gens aus coryneformen bakterien

Publications (1)

Publication Number Publication Date
BRPI0515788A true BRPI0515788A (pt) 2008-08-05

Family

ID=36088528

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515788-9A BRPI0515788A (pt) 2004-12-18 2005-11-21 alelos do gene gnd de bactérias corineformes

Country Status (8)

Country Link
US (2) US7338790B2 (pt)
EP (1) EP1824968B1 (pt)
CN (1) CN101080489B (pt)
AT (1) ATE494365T1 (pt)
BR (1) BRPI0515788A (pt)
DE (2) DE102005032426A1 (pt)
DK (1) DK1824968T3 (pt)
WO (1) WO2006063660A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005229822A (ja) * 2004-02-17 2005-09-02 Jgc Corp バイオマスから単糖を製造する方法及び単糖製造装置
DE102005032426A1 (de) 2004-12-18 2006-06-22 Degussa Ag Allele des gnd-Gens aus coryneformen Bakterien
DE102006026328A1 (de) * 2006-06-02 2008-01-03 Evonik Degussa Gmbh Verfahren zur Herstellung eines L-Lysin enthaltenden Futtermitteladditivs
DE102008001874A1 (de) 2008-05-20 2009-11-26 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
EP2940144A1 (de) 2014-04-30 2015-11-04 Evonik Degussa GmbH Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11242545B2 (en) 2016-09-01 2022-02-08 Ningxia Eppen Biotech Co., Ltd Corynebacterium for producing L-lysine by fermentation
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN106754807B (zh) * 2016-12-29 2020-10-30 廊坊梅花生物技术开发有限公司 生产l-亮氨酸菌株和生产l-亮氨酸的方法
EP3456833A1 (en) 2017-09-18 2019-03-20 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3498853A1 (en) 2017-12-14 2019-06-19 Evonik Degussa GmbH Method for the fermentative production of l-lysine
EP3594355A1 (en) 2018-07-12 2020-01-15 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3599282B1 (en) 2018-07-24 2021-03-17 Evonik Operations GmbH Method for the fermentative production of l-lysine
RU2019128538A (ru) * 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
EP3660158A1 (en) 2018-11-29 2020-06-03 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3670525A1 (en) 2018-12-18 2020-06-24 Evonik Operations GmbH Method for the fermentative production of l-lysine using c. glutamicum strains with a mutated kup transporter
US10829746B2 (en) 2019-01-23 2020-11-10 Evonik Operations Gmbh Method for the fermentative production of L-lysine
WO2021048353A1 (en) 2019-09-11 2021-03-18 Evonik Operations Gmbh Coryneform bacteria with a heterologous threonine transporter and their use in the production of l-threonine
EP4405376B1 (en) 2021-09-20 2025-08-27 Evonik Operations GmbH Method for the fermentative production of l-lysine using c. glutamicum strains expressing modified gluconate repressor proteins gntr1 and gntr2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6431600A (en) 2000-03-20 2001-10-03 Degussa A.G. Process for the fermentative preparation of l-amino acids with amplification of the gnd gene
US6822085B2 (en) * 2000-09-03 2004-11-23 Degussa Ag Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes
WO2003048351A1 (en) 2001-12-03 2003-06-12 Kyowa Hakko Kogyo Co., Ltd. Mutated 6-phosphogluconate dehydrogenase
DE102005032426A1 (de) 2004-12-18 2006-06-22 Degussa Ag Allele des gnd-Gens aus coryneformen Bakterien

Also Published As

Publication number Publication date
DE102005032426A1 (de) 2006-06-22
WO2006063660A8 (de) 2007-03-15
EP1824968B1 (de) 2011-01-05
US7338790B2 (en) 2008-03-04
ATE494365T1 (de) 2011-01-15
DE502005010816D1 (de) 2011-02-17
WO2006063660A1 (de) 2006-06-22
EP1824968A1 (de) 2007-08-29
US7563602B2 (en) 2009-07-21
DK1824968T3 (da) 2011-04-11
CN101080489B (zh) 2013-05-01
CN101080489A (zh) 2007-11-28
US20060246554A1 (en) 2006-11-02
US20080131903A1 (en) 2008-06-05

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]